Questions and Answers
What is one objective of this lecture?
What are the current problems with outcome measures in clinical trials?
Failure to collect meaningful outcomes, high variability across trials, lack of information on measurement properties, and biased reporting.
High degree of variability across trials in the outcomes reported is a problem.
True
Which of the following is a health-related quality of life instrument mentioned?
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What issue arises from the lack of information on measurement properties of outcome measures?
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Biased reporting of outcomes has been found in a significant percentage of studies.
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Study Notes
Objective of Selection Guidelines
- Aims to assist Therapists in choosing appropriate Outcome Measures (OMs).
Current Problems with OMs in Clinical Trials
- Many trials fail to collect outcomes that are meaningful to patients, such as symptom relief and patient satisfaction.
- There is a high degree of variability across trials in reported outcomes, complicating comparisons and policy decisions.
- Variation exists in the outcome measurement instruments used, leading to inconsistent data across studies.
Key Outcomes That Matter to Patients
- Important outcomes include relief of symptoms, return to work, cost-effective management, and overall patient satisfaction.
- Statistical and clinical significance is often underscored by the concept of Minimal Clinically Important Difference (MCID).
Issues In Outcome Measurement Instruments
- Numerous instruments measure similar health outcomes, but they differ in structure, scoring, and availability.
- Examples include:
- Roland Morris Disability Questionnaire (24 items, scoring 0-24, no fees)
- Oswestry Disability Index (10 items, scoring 0-100, fees may apply)
- EuroQol-5D-3L (5 items + VAS, scoring 0-100, fees may apply)
- Short Form Health Survey 12 (12 items, scores range from 0-100, fees may apply)
Lack of Information and Clarity
- There is insufficient data regarding measurement properties of outcomes, leading to confusion.
- Terminology and definitions related to measurement properties are often unclear in the literature.
- Evidence for the effectiveness of many OMs is lacking, and methods to assess these properties are inconsistent.
Biased Reporting of Outcomes
- A significant percentage (40-62%) of studies altered primary outcomes either by change, addition, or omission during the research process.
- In reviews, 55% could not incorporate all eligible studies' primary outcome data, and 86% lacked complete data on harm outcomes.
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Description
This quiz provides therapists with essential guidelines for selecting Outcome Measures (OMs) and highlights current challenges faced in clinical trials. It covers crucial factors like information bias and variability to ensure effective assessment in therapy practices.
