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Questions and Answers
What is the first-line management for acute gout attacks?
What is the first-line management for acute gout attacks?
- Allopurinol
- Colchicine (correct)
- NSAID such as indomethacin
- Corticosteroid
What lifestyle changes are recommended for management between gout attacks?
What lifestyle changes are recommended for management between gout attacks?
- Avoiding purine-rich foods (correct)
- Increasing alcohol consumption
- Taking certain medications
- Weight gain
Which medication may be indicated in patients with frequent acute gout attacks?
Which medication may be indicated in patients with frequent acute gout attacks?
- Febuxostat
- Allopurinol
- Probenecid (correct)
- Anakinra
What is the role of xanthine oxidase inhibitors in gout management?
What is the role of xanthine oxidase inhibitors in gout management?
In patients with refractory chronic gout, which newer agent has been shown to be effective in lowering uric acid levels?
In patients with refractory chronic gout, which newer agent has been shown to be effective in lowering uric acid levels?
What is the suggested role of anakinra in gout management?
What is the suggested role of anakinra in gout management?
When should uric acid lowering therapy be considered in gout management?
When should uric acid lowering therapy be considered in gout management?
What is the primary mechanism of action of corticosteroids in gout management?
What is the primary mechanism of action of corticosteroids in gout management?
What do uricosuric agents such as probenecid do in gout management?
What do uricosuric agents such as probenecid do in gout management?
What factors are specific treatment decisions based on in gout management?
What factors are specific treatment decisions based on in gout management?
What is the normal serum uric acid level?
What is the normal serum uric acid level?
Which adverse effect is a risk factor with the use of allopurinol?
Which adverse effect is a risk factor with the use of allopurinol?
What are the CNS adverse effects of allopurinol?
What are the CNS adverse effects of allopurinol?
Which medication increases the risk of uricosuric-associated toxicity when combined with allopurinol?
Which medication increases the risk of uricosuric-associated toxicity when combined with allopurinol?
What is the dosage adjustment of allopurinol based on in patients with renal impairment?
What is the dosage adjustment of allopurinol based on in patients with renal impairment?
What should the nurse assess for in patients taking allopurinol?
What should the nurse assess for in patients taking allopurinol?
What is a contraindication for taking allopurinol?
What is a contraindication for taking allopurinol?
What is the most common GI adverse effect of allopurinol?
What is the most common GI adverse effect of allopurinol?
Which medication, when combined with allopurinol, increases the risk of developing a rash?
Which medication, when combined with allopurinol, increases the risk of developing a rash?
What should the nurse assess for to monitor liver function in patients taking allopurinol?
What should the nurse assess for to monitor liver function in patients taking allopurinol?
What is the half-life of colchicine?
What is the half-life of colchicine?
How is colchicine primarily eliminated from the body?
How is colchicine primarily eliminated from the body?
What is the initial recommended dose of allopurinol for geriatric patients?
What is the initial recommended dose of allopurinol for geriatric patients?
What is the main mechanism of action of allopurinol?
What is the main mechanism of action of allopurinol?
What is a contraindication for the use of colchicine?
What is a contraindication for the use of colchicine?
What are the adverse effects of colchicine?
What are the adverse effects of colchicine?
How should colchicine be administered to reduce gastric distress?
How should colchicine be administered to reduce gastric distress?
What should be assessed by the nurse to evaluate the therapeutic effects of colchicine?
What should be assessed by the nurse to evaluate the therapeutic effects of colchicine?
What is the peak of action of allopurinol?
What is the peak of action of allopurinol?
For which condition is allopurinol not indicated?
For which condition is allopurinol not indicated?
Flashcards
What is the first-line treatment for acute gout attacks?
What is the first-line treatment for acute gout attacks?
Colchicine is the primary medication used for immediate pain relief during an acute gout attack.
What lifestyle changes are recommended between gout attacks?
What lifestyle changes are recommended between gout attacks?
Avoiding foods rich in purines, like red meat and seafood, is a key lifestyle change to manage gout. This helps lower uric acid levels.
Which medication is used for patients with frequent acute gout attacks?
Which medication is used for patients with frequent acute gout attacks?
Probenecid helps manage frequent gout attacks by increasing uric acid excretion in urine.
What is the role of xanthine oxidase inhibitors in gout management?
What is the role of xanthine oxidase inhibitors in gout management?
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Which newer agent is effective in lowering uric acid for refractory chronic gout?
Which newer agent is effective in lowering uric acid for refractory chronic gout?
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What is the suggested role of anakinra in gout management?
What is the suggested role of anakinra in gout management?
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When should uric acid lowering therapy be considered in gout management?
When should uric acid lowering therapy be considered in gout management?
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What is the primary mechanism of action of corticosteroids in gout management?
What is the primary mechanism of action of corticosteroids in gout management?
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What do uricosuric agents like probenecid do in gout management?
What do uricosuric agents like probenecid do in gout management?
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What factors are specific treatment decisions based on in gout management?
What factors are specific treatment decisions based on in gout management?
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What is the normal serum uric acid level?
What is the normal serum uric acid level?
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Which adverse effect is a risk factor with the use of allopurinol?
Which adverse effect is a risk factor with the use of allopurinol?
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What are the CNS adverse effects of allopurinol?
What are the CNS adverse effects of allopurinol?
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Which medication increases the risk of uricosuric-associated toxicity when combined with allopurinol?
Which medication increases the risk of uricosuric-associated toxicity when combined with allopurinol?
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What is the dosage adjustment of allopurinol based on in patients with renal impairment?
What is the dosage adjustment of allopurinol based on in patients with renal impairment?
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What should the nurse assess for in patients taking allopurinol?
What should the nurse assess for in patients taking allopurinol?
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What is a contraindication for taking allopurinol?
What is a contraindication for taking allopurinol?
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What is the most common GI adverse effect of allopurinol?
What is the most common GI adverse effect of allopurinol?
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Which medication, when combined with allopurinol, increases the risk of developing a rash?
Which medication, when combined with allopurinol, increases the risk of developing a rash?
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What should the nurse assess for to monitor liver function in patients taking allopurinol?
What should the nurse assess for to monitor liver function in patients taking allopurinol?
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What is the half-life of colchicine?
What is the half-life of colchicine?
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How is colchicine primarily eliminated from the body?
How is colchicine primarily eliminated from the body?
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What is the initial recommended dose of allopurinol for geriatric patients?
What is the initial recommended dose of allopurinol for geriatric patients?
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What is the main mechanism of action of allopurinol?
What is the main mechanism of action of allopurinol?
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What is a contraindication for the use of colchicine?
What is a contraindication for the use of colchicine?
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What are the adverse effects of colchicine?
What are the adverse effects of colchicine?
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How should colchicine be administered to reduce gastric distress?
How should colchicine be administered to reduce gastric distress?
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What should be assessed by the nurse to evaluate the therapeutic effects of colchicine?
What should be assessed by the nurse to evaluate the therapeutic effects of colchicine?
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What is the peak of action of allopurinol?
What is the peak of action of allopurinol?
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For which condition is allopurinol not indicated?
For which condition is allopurinol not indicated?
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Study Notes
Colchicine and Allopurinol in Gout Treatment
- Colchicine is used to treat and prevent gout, with a slow onset of action and a half-life of 26 to 31 hours.
- It is primarily eliminated in the feces and is administered cautiously in older adults, with a reduced dosage for those 70 years and older.
- For patients with renal impairment, a regular dosage is administered for mild to moderate impairment, but for creatinine clearance less than 30 mL/min, a reduced dosage is necessary.
- Colchicine should be administered cautiously in patients with hepatic impairment, and adverse effects include GI issues, hematologic effects, and hepatotoxicity.
- It is contraindicated in patients with known hypersensitivity and should not be given concurrently with certain medications or in pregnancy.
- Colchicine can result in toxicity and severe adverse effects when combined with specific medications, and it should be administered with food to reduce gastric distress.
- Therapeutic effects of colchicine occur within 24 to 48 hours after oral administration, with the nurse assessing for decreased pain, swelling, and inflammation of affected joints.
- Adverse effects of colchicine include severe GI issues, numbness, tingling, muscle weakness, bone marrow depression, and altered liver enzymes.
- Allopurinol is a xanthine oxidase inhibitor used to reduce serum uric acid levels in gout treatment, with a peak of action at 2 to 6 hours and a half-life of 1 to 3 hours.
- It inhibits the enzyme responsible for the conversion of purines to uric acid, reducing uric acid production and the symptoms of gout.
- Allopurinol is administered for the management of primary and secondary gout, acute and chronic tophaceous gout, and other indications such as leukemia and lymphoma.
- In geriatric patients, the initial dose of allopurinol is 100 mg/d, which can be increased until the desired uric acid level is obtained, with a reduced dosage for diminished renal function.
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Description
"Colchicine and Allopurinol in Gout Treatment" Quiz Test your knowledge of the pharmacology and administration of colchicine and allopurinol in the treatment of gout. Assess your understanding of dosage considerations, contraindications, therapeutic effects, and potential adverse reactions associated with these medications.
