Goldsmith Steps in Development of Disease Quiz

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Questions and Answers

What type of radiation exposure did Homer experience in the power plant accident?

  • Nonionizing radiation
  • Thermal radiation
  • Ionizing radiation (correct)
  • Ultraviolet radiation

What type of cell damage can be caused by ionizing radiation exposure?

  • Thermal burns
  • Sunburns to the skin
  • Atomic vibration and rotation
  • Free radical formation (correct)

Which of the following physical agents did Homer experience?

  • Low-intensity heat
  • Electrical injuries
  • Trauma/Mechanical forces
  • All of the above (correct)

What type of nutritional imbalance did Homer likely experience due to his injuries?

<p>Deficiencies in vitamins and minerals (A)</p> Signup and view all the answers

What type of infection did Homer develop in his burned hands?

<p>Clostridium infection (D)</p> Signup and view all the answers

What type of cell damage can be caused by nonionizing radiation?

<p>Atomic vibration and rotation (C)</p> Signup and view all the answers

What is the main cause of cellular damage in oxidative stress?

<p>Accumulation of reactive oxygen species (D)</p> Signup and view all the answers

How are free radicals defined?

<p>Chemical species with free electrons in the outer orbit (A)</p> Signup and view all the answers

What can cause an increase in intracellular [Ca2+] levels?

<p>Toxins and ischemia (B)</p> Signup and view all the answers

Which organelle is most likely to be damaged by ROS according to the text?

<p>Endoplasmic reticulum (B)</p> Signup and view all the answers

What contributes to increased intracellular [Ca2+] levels?

<p>ATPases activation (B)</p> Signup and view all the answers

Which type of injury results in increased membrane permeability and cell death?

<p>Plasma membrane damage (B)</p> Signup and view all the answers

Which of the following is NOT a type of cellular adaptation?

<p>Apoptosis (C)</p> Signup and view all the answers

Which cellular adaptation is characterized by an increase in cell size?

<p>Hypertrophy (D)</p> Signup and view all the answers

Which of the following can be a cause of cell injury?

<p>All of the above (D)</p> Signup and view all the answers

What is the main consequence of ischemia on cells?

<p>Reduced blood supply and oxygen deficiency (A)</p> Signup and view all the answers

Which type of cell injury is characterized by cells of varying size, shape, and organization in a specific tissue?

<p>Dysplasia (A)</p> Signup and view all the answers

What is the primary mechanism by which viruses can cause cell injury?

<p>DNA incorporation (D)</p> Signup and view all the answers

What is the role of the immune system in cell injury?

<p>The immune system can both protect cells from injury and cause cell injury (A)</p> Signup and view all the answers

Which type of cellular adaptation is characterized by a change from one adult cell type to another?

<p>Metaplasia (A)</p> Signup and view all the answers

Which of the following is NOT listed as a cause of cell injury in the text?

<p>Oxidative stress (C)</p> Signup and view all the answers

What is the main consequence of genetic abnormalities on cells?

<p>Decreased or increased protein function (C)</p> Signup and view all the answers

What is the primary function of chaperones in the endoplasmic reticulum (ER)?

<p>To enhance proper folding of newly synthesized proteins (A)</p> Signup and view all the answers

What is the primary purpose of the unfolded protein response (UPR)?

<p>To increase the production of chaperones and reduce protein translation (A)</p> Signup and view all the answers

Which of the following can lead to DNA damage?

<p>All of the above (D)</p> Signup and view all the answers

What is the role of p53 protein in response to DNA damage?

<p>It arrests the cell cycle to allow DNA repair (B)</p> Signup and view all the answers

Which of the following is an example of cellular adaptation?

<p>Atrophy (B)</p> Signup and view all the answers

How does necrosis differ from apoptosis?

<p>Necrosis causes cell swelling, while apoptosis causes cell shrinkage (C)</p> Signup and view all the answers

What is the primary difference between apoptosis and necrosis in terms of their physiological roles?

<p>Apoptosis is a normal physiological process, but can also be pathological in some cases (C)</p> Signup and view all the answers

Which type of necrosis is characterized by the death of a localized area of tissue or an organ due to a lack of blood supply?

<p>Infarction (D)</p> Signup and view all the answers

What is the term used to describe the death and putrefaction of soft tissues, typically caused by a lack of blood supply?

<p>Gangrene (B)</p> Signup and view all the answers

Which of the following is a proposed mechanism for cellular aging?

<p>All of the above (D)</p> Signup and view all the answers

What is the primary function of apoptosis?

<p>Controlled cell destruction (C)</p> Signup and view all the answers

Which of the following is NOT a characteristic of apoptosis?

<p>Uncontrolled release of cell products into the extracellular space (C)</p> Signup and view all the answers

Which type of necrosis is characterized by tissue softening and the persistence of dead cells as a soft, cheese-like debris?

<p>Caseous necrosis (B)</p> Signup and view all the answers

What is the primary difference between dry gangrene and moist (wet) gangrene?

<p>Dry gangrene lacks arterial blood supply, while moist gangrene lacks venous flow (D)</p> Signup and view all the answers

What is the primary function of autophagy?

<p>Survival mechanism during nutrient deprivation (C)</p> Signup and view all the answers

Which of the following is NOT a characteristic of necrosis?

<p>Controlled autodigestion via endogenous enzymes (D)</p> Signup and view all the answers

What type of necrosis is often seen in immune reactions and severe hypertension?

<p>Fibrinoid necrosis (B)</p> Signup and view all the answers

Which of the following statements about apoptosis is NOT true?

<p>It is a process that is well-understood in terms of its control mechanism (A)</p> Signup and view all the answers

Which type of necrosis is often seen in the center of an abscess?

<p>Liquefactive necrosis (B)</p> Signup and view all the answers

Which of the following statements about autophagy is true?

<p>It involves the lysosomal digestion of the cell's own components (D)</p> Signup and view all the answers

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