Glycogenesis + Regulation

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Questions and Answers

Which enzyme is responsible for the conversion of UDP-glucose to glucose 1-phosphate?

  • Branching enzyme
  • Glycogen synthase kinase 3 (GSK3)
  • UDP-glucose pyrophosphorylase (correct)
  • Protein phosphorylase 1 (PP1)

Which protein kinase is activated by insulin and plays a role in glycogenesis?

  • Protein kinase B (correct)
  • Phosphatidyl-inositol-3-kinase
  • Protein kinase A (PKA)
  • Glycogen synthase kinase 3 (GSK3)

Which process is responsible for the introduction of alpha-1,6 linkages in glycogen synthesis?

  • Branching enzyme activity (correct)
  • Glycogen synthase activity
  • UDP-glucose pyrophosphorylase activity
  • Protein phosphorylase 1 (PP1) activity

What is the primary role of protein phosphorylase 1 (PP1) in glycogen metabolism?

<p>Dephosphorylating and activating glycogen synthase (B)</p> Signup and view all the answers

Which compound is produced during the conversion of glucose 6-phosphate to glucose 1-phosphate?

<p>PPi (pyrophosphate) (B)</p> Signup and view all the answers

Which enzyme is responsible for extending both the main chain and branches in glycogen synthesis?

<p>Glycogen synthase (B)</p> Signup and view all the answers

What enzyme is responsible for inactivating glycogen synthase through phosphorylation?

<p>Protein kinase A (PKA)</p> Signup and view all the answers

Which enzyme dephosphorylates and activates glycogen synthase in glycogenesis?

<p>Protein phosphatase 1 (PP1)</p> Signup and view all the answers

What molecule activates phosphatidylinositol-3-kinase in the glycogenesis pathway?

<p>UDP-glucose</p> Signup and view all the answers

Which enzyme is responsible for introducing alpha-1,6 linkages in the branching of glycogen synthesis?

<p>Branching enzyme</p> Signup and view all the answers

What kinase is inhibited to prevent the phosphorylation and inactivation of glycogen synthase in glycogenesis?

<p>Glycogen synthase kinase 3 (GSK3)</p> Signup and view all the answers

Glycogen synthase is active when phosphorylated.

<p>False (B)</p> Signup and view all the answers

Insulin signaling leads to the activation of glycogen synthase.

<p>True (A)</p> Signup and view all the answers

Glucagon activates protein kinase B in the glycogenesis pathway.

<p>False (B)</p> Signup and view all the answers

PP1 inactivates glycogen synthase by phosphorylating it.

<p>False (B)</p> Signup and view all the answers

UDP-glucose activates phosphatidylinositol-3-kinase in glycogenesis.

<p>False (B)</p> Signup and view all the answers

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