Glycogenesis
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Summary
This document explains glycogenesis, the process of storing glucose as glycogen, and includes details on its regulation and the related enzymes and pathways. It's a biological process focusing on biochemistry and glucose metabolism.
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Glycogenesis - making glycogen to store from glucose 6-phosphate Regulation occurs at the level of glycogen synthase Glucose 6-phosphate 2 forms of glycogen synthase - a is active and non-phosphorylated - b is inactive and phosphorylated Glucose 1-phosphate Insulin signals activates receptor tyrosin...
Glycogenesis - making glycogen to store from glucose 6-phosphate Regulation occurs at the level of glycogen synthase Glucose 6-phosphate 2 forms of glycogen synthase - a is active and non-phosphorylated - b is inactive and phosphorylated Glucose 1-phosphate Insulin signals activates receptor tyrosine kinase receptor UTP UDP- glucose pyrophosphorylase How is it turned off? PKA phosphorylates and inactivates glycogen synthase PPi (pyrophosphate) IRS1 gets phosphorylated PP1 can also be inactivated by PKA so glycogen synthase remains phosphorylated so remains off UDP- glucose activates phosphatidyl-inositol-3-kinase Glycogen (n) Glycogen synthase UDP Protien kinase B is activated Glycogen Glycogen synthase kinase 3 (GSK3) is inhibited Branching enzyme to introduce the a-1,6 linkages Glucagon synthase extends both the main chain and the branch= more branching Glycogen synthase gets dephosphorylated by protein phosphorylase 1 (PP1) Glycogen synthase dephosphorylated means its active and can produce glycogen
