Podcast
Questions and Answers
What is the primary site where Type I oxidative deamination occurs?
What is the primary site where Type I oxidative deamination occurs?
Which molecule is produced as a result of Type I oxidative deamination of Glutamate?
Which molecule is produced as a result of Type I oxidative deamination of Glutamate?
How is L-Glutamate dehydrogenase regulated in terms of energy levels?
How is L-Glutamate dehydrogenase regulated in terms of energy levels?
What drives the reaction towards Glutamate synthesis in Type I oxidative deamination?
What drives the reaction towards Glutamate synthesis in Type I oxidative deamination?
Signup and view all the answers
Which amino acid undergoes rapid oxidative deamination due to its central role in nitrogen metabolism?
Which amino acid undergoes rapid oxidative deamination due to its central role in nitrogen metabolism?
Signup and view all the answers
What type of reaction is Type II oxidative deamination, in terms of reversibility?
What type of reaction is Type II oxidative deamination, in terms of reversibility?
Signup and view all the answers
What is the function of mitochondrial glutamine synthetase in the body?
What is the function of mitochondrial glutamine synthetase in the body?
Signup and view all the answers
Which enzyme releases ammonia from glutamine in the mitochondria?
Which enzyme releases ammonia from glutamine in the mitochondria?
Signup and view all the answers
What role does liver-type glutaminase play in response to high protein intake?
What role does liver-type glutaminase play in response to high protein intake?
Signup and view all the answers
How is glutamine synthesized in the process involving ATP and ADP?
How is glutamine synthesized in the process involving ATP and ADP?
Signup and view all the answers
What outcome results from a rare deficiency in neonate glutamine synthetase?
What outcome results from a rare deficiency in neonate glutamine synthetase?
Signup and view all the answers
Which enzyme is analogized to glutaminase for a similar reaction catalyzed by L-Asparaginase?
Which enzyme is analogized to glutaminase for a similar reaction catalyzed by L-Asparaginase?
Signup and view all the answers
What is the process of removal of an amino group in the form of free ammonia known as?
What is the process of removal of an amino group in the form of free ammonia known as?
Signup and view all the answers
Which type of deamination involves oxidation by removal of hydrogen?
Which type of deamination involves oxidation by removal of hydrogen?
Signup and view all the answers
Which enzyme catalyzes Type I Oxidative Deamination using glutamate as a substrate?
Which enzyme catalyzes Type I Oxidative Deamination using glutamate as a substrate?
Signup and view all the answers
In Type I Oxidative Deamination, what coenzyme can Glutamate Dehydrogenase use for the deamination reaction?
In Type I Oxidative Deamination, what coenzyme can Glutamate Dehydrogenase use for the deamination reaction?
Signup and view all the answers
What is the source of nitrogen in hepatic urea synthesis provided by the process of deamination?
What is the source of nitrogen in hepatic urea synthesis provided by the process of deamination?
Signup and view all the answers
Why is NAD+ used in oxidative deamination and NADPH used in reductive amination?
Why is NAD+ used in oxidative deamination and NADPH used in reductive amination?
Signup and view all the answers
