Podcast
Questions and Answers
What is the primary site where Type I oxidative deamination occurs?
What is the primary site where Type I oxidative deamination occurs?
- Liver & Kidney (Mitochondria) (correct)
- Heart
- Liver & Kidney (Peroxisomes)
- Brain
Which molecule is produced as a result of Type I oxidative deamination of Glutamate?
Which molecule is produced as a result of Type I oxidative deamination of Glutamate?
- NADH
- Ammonia
- NADPH
- -ketoglutarate (correct)
How is L-Glutamate dehydrogenase regulated in terms of energy levels?
How is L-Glutamate dehydrogenase regulated in terms of energy levels?
- Activated by high levels of glucose
- Allosterically inhibited by low energy (ADP) (correct)
- Inhibited by high levels of ammonia
- Allosterically activated by high energy (GTP)
What drives the reaction towards Glutamate synthesis in Type I oxidative deamination?
What drives the reaction towards Glutamate synthesis in Type I oxidative deamination?
Which amino acid undergoes rapid oxidative deamination due to its central role in nitrogen metabolism?
Which amino acid undergoes rapid oxidative deamination due to its central role in nitrogen metabolism?
What type of reaction is Type II oxidative deamination, in terms of reversibility?
What type of reaction is Type II oxidative deamination, in terms of reversibility?
What is the function of mitochondrial glutamine synthetase in the body?
What is the function of mitochondrial glutamine synthetase in the body?
Which enzyme releases ammonia from glutamine in the mitochondria?
Which enzyme releases ammonia from glutamine in the mitochondria?
What role does liver-type glutaminase play in response to high protein intake?
What role does liver-type glutaminase play in response to high protein intake?
How is glutamine synthesized in the process involving ATP and ADP?
How is glutamine synthesized in the process involving ATP and ADP?
What outcome results from a rare deficiency in neonate glutamine synthetase?
What outcome results from a rare deficiency in neonate glutamine synthetase?
Which enzyme is analogized to glutaminase for a similar reaction catalyzed by L-Asparaginase?
Which enzyme is analogized to glutaminase for a similar reaction catalyzed by L-Asparaginase?
What is the process of removal of an amino group in the form of free ammonia known as?
What is the process of removal of an amino group in the form of free ammonia known as?
Which type of deamination involves oxidation by removal of hydrogen?
Which type of deamination involves oxidation by removal of hydrogen?
Which enzyme catalyzes Type I Oxidative Deamination using glutamate as a substrate?
Which enzyme catalyzes Type I Oxidative Deamination using glutamate as a substrate?
In Type I Oxidative Deamination, what coenzyme can Glutamate Dehydrogenase use for the deamination reaction?
In Type I Oxidative Deamination, what coenzyme can Glutamate Dehydrogenase use for the deamination reaction?
What is the source of nitrogen in hepatic urea synthesis provided by the process of deamination?
What is the source of nitrogen in hepatic urea synthesis provided by the process of deamination?
Why is NAD+ used in oxidative deamination and NADPH used in reductive amination?
Why is NAD+ used in oxidative deamination and NADPH used in reductive amination?
