Endo Exam 1 Pharmacology
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Questions and Answers

Which drug class reduces glucose absorption by decreasing the conversion of carbohydrates to monomers and increasing release of GLP-1?

  • Insulin
  • Alpha-glucosidase inhibitors (correct)
  • SGLT2 inhibitors
  • Sulfonylureas

What is the mechanism of action of amylin analogs in reducing postprandial hyperglycemia?

  • Increased insulin secretion
  • Inducing satiety and lowering appetite
  • Decreased carbohydrate absorption (correct)
  • Increased glucagon secretion

Which drug acts by activating dopamine D2 receptors to decrease hypothalamic activation?

  • Bromocriptine (correct)
  • Insulin
  • SGLT2 inhibitors
  • Metformin

Which medication can be used as an adjunctive agent to insulin and has a main adverse effect of hypoglycemia?

<p>Amylin analog (B)</p> Signup and view all the answers

What is the primary function of glucagon in the body?

<p>Promote gluconeogenesis and glycogenolysis in the liver (D)</p> Signup and view all the answers

Which medication keeps the K+ ATP-channel on beta-cells open, leading to inhibition of insulin secretion?

<p>Sulfonylureas (A)</p> Signup and view all the answers

What is the main effect of diazoxide on insulin secretion?

<p>Decreased insulin release (C)</p> Signup and view all the answers

What is the role of Gs-coupled glucagon receptors activation in the body?

<p>Increase cAMP levels and promote actions opposing insulin (B)</p> Signup and view all the answers

How do amylin analogs affect glucagon secretion in diabetic patients?

<p>Decrease glucagon secretion (B)</p> Signup and view all the answers

What is the main mechanism of action of A-glucosidase inhibitors acarbose and miglitol?

<p>Inhibit conversion of carbohydrates to monomers for absorption (B)</p> Signup and view all the answers

Which of the following hormones is known for acting via nuclear receptors to modulate gene transcription in target cells?

<p>Thyroid hormones (D)</p> Signup and view all the answers

Which cell type in the endocrine pancreas produces insulin, proinsulin, C-peptide, and amylin?

<p>Beta cells (A)</p> Signup and view all the answers

What is the primary function of somatostatin in the endocrine system?

<p>Inhibit hormone secretion (D)</p> Signup and view all the answers

Which of the following hormones exerts rapid effects on signal transduction pathways via membrane receptors?

<p>Insulin (D)</p> Signup and view all the answers

What type of hormone is insulin considered to be?

<p>Peptide hormone (A)</p> Signup and view all the answers

Which class of hormones includes insulin as one of its members?

<p>GLP-1 agonists (D)</p> Signup and view all the answers

Metformin is commonly used to treat which condition?

<p><strong>Type 2 diabetes</strong> (A)</p> Signup and view all the answers

Sulfonylureas are medications commonly used to:

<p><strong>Stimulate insulin release</strong> (B)</p> Signup and view all the answers

SGLT2 inhibitors are known to primarily act by:

<p><strong>Reducing glucose reabsorption</strong> (A)</p> Signup and view all the answers

GLP-1 agonists are beneficial in diabetes as they:

<p><strong>Enhance insulin secretion</strong> (C)</p> Signup and view all the answers

Metformin is unique because it does NOT typically cause:

<p><strong>Weight gain</strong> (D)</p> Signup and view all the answers

What is a common side effect associated with sulfonylureas use?

<p>Hypoglycemia (D)</p> Signup and view all the answers

Which of the following best describes how metformin affects glucose production?

<p>Inhibits mitochondrial respiration chain (D)</p> Signup and view all the answers

What is the main transporter for renal glucose reabsorption against the gradient?

<p>SGLT2 transporter (C)</p> Signup and view all the answers

Which drug class primarily leads to increased glucose excretion via glycosuria?

<p>SGLT2 inhibitors (A)</p> Signup and view all the answers

How does metformin affect insulin sensitivity?

<p>Increases insulin sensitivity (B)</p> Signup and view all the answers

Which ADR is commonly associated with SGLT2 inhibitors?

<p>Increased risk of urinary tract infections (C)</p> Signup and view all the answers

What is the major effect of SGLT2 inhibitors on glucose threshold for excretion?

<p>Decrease threshold to 50 mg/dL (D)</p> Signup and view all the answers

What distinguishes metformin from other antidiabetic drugs in terms of hypoglycemic risk?

<p>It lacks any hypoglycemic risk (B)</p> Signup and view all the answers

Which drug class mainly focuses on reducing glucose reabsorption in the kidneys?

<p>SGLT2 inhibitors (D)</p> Signup and view all the answers

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