Endo Exam 1 Pharmacology
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Questions and Answers

Which drug class reduces glucose absorption by decreasing the conversion of carbohydrates to monomers and increasing release of GLP-1?

  • Insulin
  • Alpha-glucosidase inhibitors (correct)
  • SGLT2 inhibitors
  • Sulfonylureas
  • What is the mechanism of action of amylin analogs in reducing postprandial hyperglycemia?

  • Increased insulin secretion
  • Inducing satiety and lowering appetite
  • Decreased carbohydrate absorption (correct)
  • Increased glucagon secretion
  • Which drug acts by activating dopamine D2 receptors to decrease hypothalamic activation?

  • Bromocriptine (correct)
  • Insulin
  • SGLT2 inhibitors
  • Metformin
  • Which medication can be used as an adjunctive agent to insulin and has a main adverse effect of hypoglycemia?

    <p>Amylin analog</p> Signup and view all the answers

    What is the primary function of glucagon in the body?

    <p>Promote gluconeogenesis and glycogenolysis in the liver</p> Signup and view all the answers

    Which medication keeps the K+ ATP-channel on beta-cells open, leading to inhibition of insulin secretion?

    <p>Sulfonylureas</p> Signup and view all the answers

    What is the main effect of diazoxide on insulin secretion?

    <p>Decreased insulin release</p> Signup and view all the answers

    What is the role of Gs-coupled glucagon receptors activation in the body?

    <p>Increase cAMP levels and promote actions opposing insulin</p> Signup and view all the answers

    How do amylin analogs affect glucagon secretion in diabetic patients?

    <p>Decrease glucagon secretion</p> Signup and view all the answers

    What is the main mechanism of action of A-glucosidase inhibitors acarbose and miglitol?

    <p>Inhibit conversion of carbohydrates to monomers for absorption</p> Signup and view all the answers

    Which of the following hormones is known for acting via nuclear receptors to modulate gene transcription in target cells?

    <p>Thyroid hormones</p> Signup and view all the answers

    Which cell type in the endocrine pancreas produces insulin, proinsulin, C-peptide, and amylin?

    <p>Beta cells</p> Signup and view all the answers

    What is the primary function of somatostatin in the endocrine system?

    <p>Inhibit hormone secretion</p> Signup and view all the answers

    Which of the following hormones exerts rapid effects on signal transduction pathways via membrane receptors?

    <p>Insulin</p> Signup and view all the answers

    What type of hormone is insulin considered to be?

    <p>Peptide hormone</p> Signup and view all the answers

    Which class of hormones includes insulin as one of its members?

    <p>GLP-1 agonists</p> Signup and view all the answers

    Metformin is commonly used to treat which condition?

    <p><strong>Type 2 diabetes</strong></p> Signup and view all the answers

    Sulfonylureas are medications commonly used to:

    <p><strong>Stimulate insulin release</strong></p> Signup and view all the answers

    SGLT2 inhibitors are known to primarily act by:

    <p><strong>Reducing glucose reabsorption</strong></p> Signup and view all the answers

    GLP-1 agonists are beneficial in diabetes as they:

    <p><strong>Enhance insulin secretion</strong></p> Signup and view all the answers

    Metformin is unique because it does NOT typically cause:

    <p><strong>Weight gain</strong></p> Signup and view all the answers

    What is a common side effect associated with sulfonylureas use?

    <p>Hypoglycemia</p> Signup and view all the answers

    Which of the following best describes how metformin affects glucose production?

    <p>Inhibits mitochondrial respiration chain</p> Signup and view all the answers

    What is the main transporter for renal glucose reabsorption against the gradient?

    <p>SGLT2 transporter</p> Signup and view all the answers

    Which drug class primarily leads to increased glucose excretion via glycosuria?

    <p>SGLT2 inhibitors</p> Signup and view all the answers

    How does metformin affect insulin sensitivity?

    <p>Increases insulin sensitivity</p> Signup and view all the answers

    Which ADR is commonly associated with SGLT2 inhibitors?

    <p>Increased risk of urinary tract infections</p> Signup and view all the answers

    What is the major effect of SGLT2 inhibitors on glucose threshold for excretion?

    <p>Decrease threshold to 50 mg/dL</p> Signup and view all the answers

    What distinguishes metformin from other antidiabetic drugs in terms of hypoglycemic risk?

    <p>It lacks any hypoglycemic risk</p> Signup and view all the answers

    Which drug class mainly focuses on reducing glucose reabsorption in the kidneys?

    <p>SGLT2 inhibitors</p> Signup and view all the answers

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