4 Questions
What is another name for metaplasia of the normal esophageal lining into intestinal glandular columnar epithelium?
Barret esophagus
What condition may glandular metaplasia of the esophageal lining lead to?
Esophageal adenocarcinoma
Eosinophilic Mallory bodies are found in the hepatocytes in which condition?
Alcoholic steatohepatitis
Match the following terms with their correct definitions:
Mallory bodies = Characteristic for alcoholic steatohepatitis in liver Gastric ulcer = Punched-out defect with smooth and clean base Gastrointestinal stromal tumor (GIST) = Type of tumor found in the gastrointestinal tract Ulcerative colitis = Chronic transmural inflammation in colon
Study Notes
Glandular Metaplasia of Surface Squamous Epithelium
- Also known as Barrett's esophagus
- Caused by Gastro-esophageal reflux disease (GERD)
- Fate: may lead to esophageal adenocarcinoma
Esophageal Carcinoma
- Types: Squamous cell carcinoma, Adenocarcinoma
- Squamous cell carcinoma: common in upper third of esophagus
- Adenocarcinoma: common in lower third of esophagus
Gastric Carcinoma
- Types: Adenocarcinoma (intestinal type, diffuse infiltrating type)
- May cause linitis plastica or leather bottle appearance
- May lead to ulcerated, infiltrative, or metastatic carcinoma
Bowel Diseases
- Crohn's disease: chronic transmural inflammation and noncaseating granulomas
- Ulcerative colitis: may lead to adenocarcinoma
- Chronic calcular cholecystitis: causes gallstones
Pancreatic Tumors
- Pancreatic duct adenocarcinoma
- Pleomorphic adenoma: triphasic
Liver Diseases
- Liver Cirrhosis
- Fatty change of liver (Steatosis): characterized by fat globules in hepatocytes
- Mallory bodies: characteristic of alcoholic steatohepatitis
- Focal nodular hyperplasia: benign tumor
- Hepatocellular carcinoma: primary liver cancer
- Regenerative Cirrhotic Nodule: benign tumor
Other Tumors
- Mucoepidermoid carcinoma
- Warthin tumor
- Gastrointestinal stromal tumor (GIST)
- Tongue squamous cell carcinoma
- Leukoplakia: precursor to squamous cell carcinoma
Quiz on glandular metaplasia of surface squamous epithelium, also known as Barret esophagus, and its relation to esophageal cancer and other gastrointestinal disorders.
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