Gastrointestinal System Pathology for 3rd Year Medical Students

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What occurs in long-term takers of acid secretion inhibitors?

A pure form of parietal cell hypertrophy without hyperacidity (correct)

An immediate rebound of excess acid secretion

A permanent cessation of acid secretion

A complete absence of tumors in the esophagus

What is the classification of mucosal polyps?

Neoplastic and non-neoplastic with a mix of benign and malignant lesions

Benign and malignant with a mix of neoplastic and non-neoplastic lesions

Benign or malignant

Neoplastic or non-neoplastic (correct)

What is the composition of non-neoplastic gastric polyps?

A mixture of hyperplastic surface epithelium and smooth muscle tissue

A mixture of hyperplastic surface epithelium and cystically dilated glandular tissue (correct)

A mixture of hyperplastic surface epithelium and cartilage tissue

A mixture of hyperplastic surface epithelium and nerve tissue

What percentage of upper GI endoscopies identify polyps?

Up to 5% of upper GI endoscopies Signup and view all the answers

What is the characteristic of non-neoplastic gastric polyps?

They are small and sessile Signup and view all the answers

What percentage of gastric polyps are adenomas?

5% to 10% Signup and view all the answers

What is the characteristic of gastric adenomas in terms of number?

They are usually single Signup and view all the answers

What is the underlying cause of gastric gland hyperplasia in Zollinger-Ellison syndrome?

Gastrinoma Signup and view all the answers

What is the percentage of non-neoplastic polyps among gastric polyps?

Up to 90% of gastric polyps Signup and view all the answers

What is the characteristic feature of Ménétrier disease?

Profound hyperplasia of the surface mucous cells with accompanying glandular atrophy Signup and view all the answers

Where are most hyperplastic polyps commonly located?

Antrum Signup and view all the answers

What is the most common type of malignant tumor in the stomach?

Gastric adenocarcinoma Signup and view all the answers

What is the characteristic of adenomatous change in the stomach?

It covers a large region of flat gastric mucosa without forming a mass lesion Signup and view all the answers

What is the characteristic of inflammatory fibroid polyps in terms of location?

They are most frequently found in the distal stomach Signup and view all the answers

What is the characteristic of Hindgut carcinoid tumors?

Almost always benign and less than 2 cm in diameter Signup and view all the answers

Which of the following is associated with hyperplasia of the parietal and chief cells within gastric glands?

Hypertrophic-hypersecretory gastropathy Signup and view all the answers

What is the characteristic feature of hypertrophic gastropathy?

Giant cerebriform enlargement of the rugal folds of the gastric mucosa Signup and view all the answers

What is the common clinical importance of all three variants of hypertrophic gastropathy?

They may mimic infiltrative carcinoma or lymphoma of the stomach Signup and view all the answers

What is the most important prognostic factor for GI carcinoid tumors?

Location Signup and view all the answers

What is the clinical consequence of hypertrophic-hypersecretory gastropathy and Zollinger-Ellison syndrome?

Increased risk of peptic ulceration Signup and view all the answers

What is the percentage of gastric lymphomas associated with chronic gastritis and H.pylori infection?

>80% Signup and view all the answers

What is the typical appearance of the chromatin texture in carcinoid tumors?

Fine and coarse clumps Signup and view all the answers

What is the term used to describe tumors that resemble smooth muscle cells?

Leiomyomas Signup and view all the answers

Which type of carcinoid tumors rarely metastasize and are generally cured by resection?

Foregut carcinoid tumors Signup and view all the answers

What percentage of all gastric malignancies do gastric lymphomas represent?

5% Signup and view all the answers

What can be seen in a large GIST tumor?

Necrosis or cystic changes Signup and view all the answers

What is the most common type of gastric lymphoma?

B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) Signup and view all the answers

What is the name given to the histopathological feature of MALT lymphoma characterized by atypical lymphocytes surrounding gastric glands?

Lymphoid epithelioid lesion Signup and view all the answers

What is the characteristic of the cut surface of a GIST tumor?

Tan and usually lacks the whirling smooth muscle pattern Signup and view all the answers

What type of cells can be exhibited by a GIST tumor microscopically?

Either spindle cells, epithelioid cells, or a mixture of both Signup and view all the answers