GI DRUGS: Antacids, H2 Blockers, PPIs, Laxatives, and More

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Questions and Answers

Why is sodium bicarbonate considered dangerous for heart patients?

  • Because it can cause ulcers
  • Because it can cause diarrhea
  • Because it can interact with antacids
  • Because it contains too much sodium (correct)

What is the primary action of histamine blockers such as cimetidine?

  • Neutralizing acid in the stomach
  • Stimulating gastric acid secretion
  • Increasing gut motility
  • Blocking histamine to reduce acid secretion (correct)

What is the typical duration of therapy required to heal an ulcer using histamine blockers?

  • 3-6 months
  • 2-4 weeks
  • 6-8 weeks (correct)
  • 1-2 years

What is the primary action of proton pump inhibitors such as omeprazole?

<p>Suppressing gastric acid secretion (D)</p> Signup and view all the answers

What type of laxative should be tried first in patients with constipation?

<p>Bulk-forming laxatives (C)</p> Signup and view all the answers

What is the mechanism of action of stimulant laxatives such as bisacodyl?

<p>Stimulating gut motility and fluid movement (A)</p> Signup and view all the answers

What is the primary mechanism of action for antacid drugs?

<p>They neutralize the gastric acid that has already been secreted. (C)</p> Signup and view all the answers

What is a common side effect of Aluminum hydroxide antacids?

<p>Constipation (D)</p> Signup and view all the answers

Why should antacids be used with caution in patients with renal disease?

<p>Because they can exacerbate kidney disease (C)</p> Signup and view all the answers

What is an important consideration for diabetic patients taking antacids?

<p>The sugar content of the antacid (C)</p> Signup and view all the answers

What is the purpose of antacids in patients with ulcers caused by H. Pylori?

<p>To neutralize the stomach acid (D)</p> Signup and view all the answers

What is a common ingredient in many antacid products?

<p>All of the above (D)</p> Signup and view all the answers

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Study Notes

GI Drugs

  • Antacids: neutralize gastric acid that has already been secreted
  • Examples: Aluminum hydroxide (e.g., Maalox), Magnesium hydroxide (e.g., Mylanta), Calcium carbonate (e.g., Tums), Sodium bicarbonate (e.g., Baking Soda)

Nursing Implications for Antacids

  • Considerations: taste, cost, sodium content, potential interactions with other drugs
  • Aluminum hydroxide may cause constipation, while Magnesium salts may cause diarrhea
  • Use with caution in renal patients and diabetics
  • Sodium bicarbonate is contraindicated in heart patients due to high sodium content

Histamine Blockers

  • Prototypes: Cimetidine (Tagamet), Ranitidine (Zantac), Famotidine (Pepcid)
  • Action: block histamine, which stimulates HCL acid secretion
  • Dosage forms: oral, parenteral (IV infusions q 6 hours)
  • Therapy duration: often 6-8 weeks to heal ulcer
  • Side effects: few, including headache

Proton Pump Inhibitors

  • Action: suppress gastric acid secretion by blocking H+ and enzyme system
  • Examples: Prevacid (Lansoprazole), Prilosec (Omeprazole)
  • Prevent ulcers

Laxatives; Cathartics; Antidiarrheal

  • Two groups: relieve constipation and treat diarrhea
  • Factors affecting GI motility: exercise, diet, stress, travel, fluid intake
  • Incorrect use of OTC drugs for constipation or as a weight loss aid

Categories of Laxatives

  • Bulk-forming laxatives: Psyllium (e.g., Metamucil), bran
  • Saline laxative cathartics: Milk of Magnesia, Phosphosoda enemas
  • Hyperosmotic agents: glycerin (glycerin suppository)
  • Stimulant irritants: Biscodyl (Dulcolax), Castor Oil
  • Stool-softening agents

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