Podcast
Questions and Answers
What determines the presence of each type of CDK-cyclin complex?
What determines the presence of each type of CDK-cyclin complex?
- Stimulation of apoptosis
- Synthesis of specific cyclins at certain times (correct)
- Inhibition of CDK activity
- Destruction of cyclins that are needed
Which CDK-cyclin complex is involved in the transition from the G1 to the S phase of the cell cycle?
Which CDK-cyclin complex is involved in the transition from the G1 to the S phase of the cell cycle?
- Cyc D-CDK4/6
- CycB-Cdk1
- CDK2-cyclin E (correct)
- Cyc A-CDK1
What is the role of CycB-Cdk1 in the cell cycle?
What is the role of CycB-Cdk1 in the cell cycle?
- Phosphorylating lamin and leading to nuclear envelope breakdown during early mitosis (correct)
- Promoting G1 progression
- Initiating apoptosis
- Regulating S-phase
What is the purpose of the G1-to-S checkpoint?
What is the purpose of the G1-to-S checkpoint?
What happens to cells producing p53 in response to DNA damage?
What happens to cells producing p53 in response to DNA damage?
What is the primary function of checkpoints in cell division?
What is the primary function of checkpoints in cell division?
What is the outcome of apoptosis?
What is the outcome of apoptosis?
What is the result of gene amplification in tumor cells?
What is the result of gene amplification in tumor cells?
What is the characteristic of oncogenes?
What is the characteristic of oncogenes?
What is the effect of mutations in tumor-suppressor genes?
What is the effect of mutations in tumor-suppressor genes?
What is the main difference between proto-oncogenes and tumor-suppressor genes?
What is the main difference between proto-oncogenes and tumor-suppressor genes?
What is the consequence of cells with defective checkpoints?
What is the consequence of cells with defective checkpoints?
What is the main function of CDKs in the cell cycle?
What is the main function of CDKs in the cell cycle?
What happens to lamins during mitosis?
What happens to lamins during mitosis?
How many cyclins have been identified in mammals?
How many cyclins have been identified in mammals?
What type of mutation results in increased proliferation in oncogenes?
What type of mutation results in increased proliferation in oncogenes?
What is the role of cyclins in the cell cycle?
What is the role of cyclins in the cell cycle?
What is the significance of studying cell-cycle mutants in yeast?
What is the significance of studying cell-cycle mutants in yeast?
What is the role of tumor suppressor genes?
What is the role of tumor suppressor genes?
How do retroviruses contribute to the formation of oncogenes?
How do retroviruses contribute to the formation of oncogenes?
What is the result of CDKs phosphorylating proteins?
What is the result of CDKs phosphorylating proteins?
What is the characteristic of oncogenes in terms of their action?
What is the characteristic of oncogenes in terms of their action?
What is the role of proto-oncogenes?
What is the role of proto-oncogenes?
What is the result of loss-of-function mutations in both copies of a tumor suppressor gene?
What is the result of loss-of-function mutations in both copies of a tumor suppressor gene?
What type of kinases are Cyclin-Dependent Kinases (CDKs)?
What type of kinases are Cyclin-Dependent Kinases (CDKs)?
What is the role of cyclins in the regulation of cell cycle progression?
What is the role of cyclins in the regulation of cell cycle progression?
How many CDKs are involved in cell cycle progression, according to the text?
How many CDKs are involved in cell cycle progression, according to the text?
What is the condition for CDKs to be active?
What is the condition for CDKs to be active?
What is the purpose of CDK7, 8, 9, 11, and 12?
What is the purpose of CDK7, 8, 9, 11, and 12?
