Genetics & Biotechnology: Hardy-Weinberg Theorem
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Questions and Answers

What is the sum of the frequencies of the two alleles in a Hardy-Weinberg population?

  • 2pq
  • p + q (correct)
  • p² + q²
  • p - q
  • What is the frequency of the Aa genotype in a Hardy-Weinberg population?

  • pq
  • 2pq (correct)
  • What is the pattern of inheritance of cystic fibrosis?

  • X-linked recessive
  • Autosomal recessive (correct)
  • Mitochondrial
  • Autosomal dominant
  • What is the frequency of the AA genotype in a Hardy-Weinberg population?

    <p>p²</p> Signup and view all the answers

    What is the incidence of cystic fibrosis in people of Irish ethnicity?

    <p>1 in 1,600</p> Signup and view all the answers

    What is the condition for a population to be in Hardy-Weinberg Equilibrium at a genetic locus?

    <p>Frequency of AA homozygotes = p2, frequency of Aa heterozygotes = 2pq, and frequency of aa homozygotes = q2</p> Signup and view all the answers

    If the frequency of the mutated CFTR allele is 0.3, what is the frequency of the normal CF allele?

    <p>0.7</p> Signup and view all the answers

    What is the definition of evolution from a population genetics perspective?

    <p>A generation-to-generation change in a population's allele or genotype frequencies over time</p> Signup and view all the answers

    What is the implication of a population not being in Hardy-Weinberg Equilibrium at a genetic locus?

    <p>Microevolution is occurring at that locus</p> Signup and view all the answers

    What is the purpose of estimating the frequency of heterozygous carriers in a population?

    <p>To determine the incidence of an autosomal recessive disease</p> Signup and view all the answers

    What is the expected outcome of a population with a specific allele that confers resistance to a disease, over many generations?

    <p>The allele will become fixed, with a frequency of 1.0.</p> Signup and view all the answers

    What is the primary mechanism by which genetic variation is preserved in a population, despite the tendency of natural selection to eliminate it?

    <p>Balancing selection and diploidy</p> Signup and view all the answers

    What is the significance of the Fy0 allele in African populations, where malaria is prevalent?

    <p>It confers resistance to malaria, and has a high frequency in the population.</p> Signup and view all the answers

    What is the expected outcome of a population that is subject to balancing selection, over many generations?

    <p>The population will exhibit a high degree of genetic variation.</p> Signup and view all the answers

    What is the primary function of the Duffy gene in humans?

    <p>It encodes a protein that confers resistance to malaria.</p> Signup and view all the answers

    What is the consequence of inbreeding on the frequency of heterozygotes over time?

    <p>The frequency of heterozygotes decreases</p> Signup and view all the answers

    Which of the following is NOT a condition required for Hardy-Weinberg Equilibrium?

    <p>Genetic drift</p> Signup and view all the answers

    What is the expected frequency of Aa individuals in Generation 1, given p = 0.5 and q = 0.5?

    <p>0.5</p> Signup and view all the answers

    What is the consequence of non-random mating on the gene pool?

    <p>It decreases genetic variation</p> Signup and view all the answers

    Which of the following is a consequence of mutation on the gene pool?

    <p>It increases genetic variation</p> Signup and view all the answers

    What is the reason for the higher frequency of the RP allele in Tristan da Cunha compared to Britain?

    <p>Founder effect</p> Signup and view all the answers

    What is the result of gene flow between two populations with different allele frequencies?

    <p>Decreased genetic differences between the populations</p> Signup and view all the answers

    What is the condition required for Hardy-Weinberg Equilibrium to be maintained?

    <p>No gene flow</p> Signup and view all the answers

    What is the effect of inbreeding in a population?

    <p>Decreased genetic variation</p> Signup and view all the answers

    What is the result of genetic drift in a small population?

    <p>Decreased genetic variation</p> Signup and view all the answers

    What is the primary mechanism by which alleles with negative effects can persist in a population?

    <p>Propagation via heterozygous genotypes</p> Signup and view all the answers

    In the context of sickle-cell anaemia, what is the advantage of being heterozygous for the HbS allele?

    <p>Heterozygote advantage against malaria</p> Signup and view all the answers

    What is the assumption required for the Hardy-Weinberg theorem to hold true?

    <p>Random mating among individuals</p> Signup and view all the answers

    What is the effect of inbreeding on the frequency of recessive alleles?

    <p>Increased frequency of recessive alleles</p> Signup and view all the answers

    What is the consequence of a missense mutation in the β-globin gene DNA sequence?

    <p>Production of a sickle-shaped protein</p> Signup and view all the answers

    What is the likely reason for the lack of genetic variation in the Cheetah population?

    <p>Bottleneck effect due to climate change</p> Signup and view all the answers

    What is the term for the phenomenon where a few individuals colonize a new habitat and establish a new population?

    <p>Founder Effect</p> Signup and view all the answers

    What is the term for the genetic locus associated with disease susceptibility in the cheetah population?

    <p>MHC</p> Signup and view all the answers

    What is the frequency of the allele associated with Retinitis Pigmentosa in the Tristan da Cunha population?

    <p>0.13</p> Signup and view all the answers

    What is the name of the disease caused by mutations in the rhodopsin gene (RHO) on HSA3?

    <p>Retinitis Pigmentosa</p> Signup and view all the answers

    What is the frequency of Retinitis Pigmentosa in the British population?

    <p>1/4,000</p> Signup and view all the answers

    What is the likely reason for the high incidence of Retinitis Pigmentosa on Tristan da Cunha?

    <p>High frequency of the allele in the founding population</p> Signup and view all the answers

    What is the name of the genetic phenomenon that occurs when a population undergoes a severe reduction in size?

    <p>Bottleneck Effect</p> Signup and view all the answers

    What is the likely effect of the Bottleneck Effect on a population's genetic variation?

    <p>Decreased genetic variation</p> Signup and view all the answers

    What is the term for the study of the inheritance of traits in populations?

    <p>Population Genetics</p> Signup and view all the answers

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