10 Questions
What are SNP detection technologies used for?
To scan for new polymorphisms and determine the allele(s) of a known polymorphism in target sequences.
What limits global SNP discovery?
Amount of funding available for the activity.
What has driven the evolution of SNP detection technologies?
The Human Genome Project.
What methods are commonly used for local, target, SNP discovery?
Direct DNA sequencing or denaturing high performance liquid chromatography (dHPLC).
Why is there no single method able to meet all the needs of SNP studies?
The demand for SNP genotyping is great.
What must be done to further improve SNP detection technologies?
Develop new approaches to lower costs and increase speed.
What is the main focus of SNP genotyping?
Genotyping individuals.
What is the significance of the nearly completed human genome sequence in SNP detection?
It provides the reference against which all other sequencing data can be compared.
What is the current status of SNP genotyping methods?
Many robust methods are currently available.
What has been the trend in the number of SNP genotyping methods in recent years?
The number of SNP genotyping methods has exploded.
Learn about the process of genetic analysis using an ABI 310 Capillary Genetic Analyzer, including sample preparation, electrophoresis, and data analysis with GeneScan software. Understand the role of selective amplification and internal size standards in the analysis.
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