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Questions and Answers
Which enzyme deficiency is responsible for about half the cases of autosomal recessive SCID?
Which enzyme deficiency is responsible for about half the cases of autosomal recessive SCID?
- Recombinase (RAG1 or RAG2)
- Adenosine deaminase (ADA) (correct)
- Purine nucleotide phosphorylase (PNP)
- Endonuclease (Artemis)
Which type of cells are particularly susceptible to injury by purine metabolites in ADA deficiency?
Which type of cells are particularly susceptible to injury by purine metabolites in ADA deficiency?
- Proliferating cells
- B cells
- T cells
- Lymphocytes (correct)
Which gene mutation results in failure of B and T cell development?
Which gene mutation results in failure of B and T cell development?
- PNP gene
- RAG1 or RAG2 gene (correct)
- Artemis gene
- ADA gene
Which genetic abnormality is responsible for about half of the cases of SCID?
Which genetic abnormality is responsible for about half of the cases of SCID?
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Which type of cells are deficient in SCID patients with mutations in the IL-2 receptor?
Which type of cells are deficient in SCID patients with mutations in the IL-2 receptor?
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What is the underlying cause of SCID?
What is the underlying cause of SCID?
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