Podcast
Questions and Answers
What is the most common clinical feature associated with IgA deficiency?
What is the most common clinical feature associated with IgA deficiency?
- Recurrent cellulitis
- Recurrent otitis media (correct)
- Chronic sinus congestion
- Chronic diarrhea
Which of the following autoimmune diseases is more commonly seen in individuals with IgA deficiency?
Which of the following autoimmune diseases is more commonly seen in individuals with IgA deficiency?
- Graves' disease
- Rheumatoid arthritis (correct)
- Multiple sclerosis
- Type 1 diabetes
What potentially deadly complication can occur post-blood transfusion in individuals with IgA deficiency?
What potentially deadly complication can occur post-blood transfusion in individuals with IgA deficiency?
- Sepsis
- Acute kidney injury
- Severe anemia
- Life-threatening anaphylaxis (correct)
Which immunoglobulin is typically deficient in patients with Hyper-IgM syndrome?
Which immunoglobulin is typically deficient in patients with Hyper-IgM syndrome?
What genetic inheritance pattern is associated with Hyper-IgM syndrome due to a CD40L deficit or lack of function?
What genetic inheritance pattern is associated with Hyper-IgM syndrome due to a CD40L deficit or lack of function?
What is the most common deficiency in complement defects?
What is the most common deficiency in complement defects?
Which cytokine receptors are affected in X-linked SCID due to mutation in the gamma-chain?
Which cytokine receptors are affected in X-linked SCID due to mutation in the gamma-chain?
What is the consequence of adenosine deaminase mutation in autosomal recessive SCID?
What is the consequence of adenosine deaminase mutation in autosomal recessive SCID?
What pathology is commonly seen in SCID patients?
What pathology is commonly seen in SCID patients?
What condition may occur in SCID if the mother's T-cells are transferred across the placenta?
What condition may occur in SCID if the mother's T-cells are transferred across the placenta?
Which virulence factor produced by Staphylococcus aureus disrupts the membranes of a large number of cell types?
Which virulence factor produced by Staphylococcus aureus disrupts the membranes of a large number of cell types?
What is the primary function of Epidermal Cell Differentiation Inhibitors produced by Staphylococcus aureus?
What is the primary function of Epidermal Cell Differentiation Inhibitors produced by Staphylococcus aureus?
Which type of toxins from Staphylococcus aureus is also known as Toxic Shock Syndrome Toxin?
Which type of toxins from Staphylococcus aureus is also known as Toxic Shock Syndrome Toxin?
What type of immunodeficiency is primarily genetic and often detected in infancy or childhood?
What type of immunodeficiency is primarily genetic and often detected in infancy or childhood?
Immunodeficiencies that are acquired due to external factors like infection or chemotherapy are classified as:
Immunodeficiencies that are acquired due to external factors like infection or chemotherapy are classified as:
Which of the following statements about X-linked agammaglobulinemia (Bruton's agammaglobulinemia) is correct?
Which of the following statements about X-linked agammaglobulinemia (Bruton's agammaglobulinemia) is correct?
Which of the following statements about common variable immunodeficiency (CVID) is incorrect?
Which of the following statements about common variable immunodeficiency (CVID) is incorrect?
What is the approximate prevalence of isolated IgA deficiency in the population?
What is the approximate prevalence of isolated IgA deficiency in the population?
Which of the following primary immunodeficiencies is the most common among B-cell deficiencies?
Which of the following primary immunodeficiencies is the most common among B-cell deficiencies?
Which of the following is the most appropriate treatment for X-linked agammaglobulinemia (Bruton's agammaglobulinemia)?
Which of the following is the most appropriate treatment for X-linked agammaglobulinemia (Bruton's agammaglobulinemia)?
What molecule is considered most important in the pathogenesis of hereditary angioedema?
What molecule is considered most important in the pathogenesis of hereditary angioedema?
Which of the following is NOT a clinical feature of hereditary angioedema?
Which of the following is NOT a clinical feature of hereditary angioedema?
What is the mechanism behind the increased risk of infections with prolonged systemic glucocorticoid use?
What is the mechanism behind the increased risk of infections with prolonged systemic glucocorticoid use?
Which of the following is the most accurate statement regarding the prevalence of hereditary angioedema?
Which of the following is the most accurate statement regarding the prevalence of hereditary angioedema?
Which of the following statements about the treatment and prognosis of hereditary angioedema is correct?
Which of the following statements about the treatment and prognosis of hereditary angioedema is correct?
What is the relative risk of bacterial infections in IBD patients on corticosteroids alone?
What is the relative risk of bacterial infections in IBD patients on corticosteroids alone?
Which infection has a 4-fold higher relative risk in IBD patients on corticosteroids alone?
Which infection has a 4-fold higher relative risk in IBD patients on corticosteroids alone?
What is the specific infection mentioned in relation to Pneumocystis jiroveci pneumonia?
What is the specific infection mentioned in relation to Pneumocystis jiroveci pneumonia?
Which infection can persist for several decades and reactivate with glucocorticoid exposure?
Which infection can persist for several decades and reactivate with glucocorticoid exposure?
What is the recommended treatment for Strongyloidiasis?
What is the recommended treatment for Strongyloidiasis?
Which virus causes Herpes Zoster (Shingles)?
Which virus causes Herpes Zoster (Shingles)?
What infection should be tested for before initiating glucocorticoid treatment?
What infection should be tested for before initiating glucocorticoid treatment?
Which type of infection can be acquired through direct contact with contaminated soil?
Which type of infection can be acquired through direct contact with contaminated soil?
Which opportunistic infections are mentioned in the text?
Which opportunistic infections are mentioned in the text?
What type of prophylactic or treatment approach is recommended for Pneumocystis jiroveci pneumonia?
What type of prophylactic or treatment approach is recommended for Pneumocystis jiroveci pneumonia?
In patients with X-linked hyper-IgM syndrome, which of the following is a characteristic finding?
In patients with X-linked hyper-IgM syndrome, which of the following is a characteristic finding?
In 22q11 deletion (DiGeorge) syndrome, which of the following is the most likely underlying cause?
In 22q11 deletion (DiGeorge) syndrome, which of the following is the most likely underlying cause?
Which of the following clinical features is NOT associated with 22q11 deletion (DiGeorge) syndrome?
Which of the following clinical features is NOT associated with 22q11 deletion (DiGeorge) syndrome?
What is the estimated prevalence of X-linked hyper-IgM syndrome?
What is the estimated prevalence of X-linked hyper-IgM syndrome?
Which of the following electrolyte abnormalities would be associated with hypoparathyroidism, a feature of 22q11 deletion (DiGeorge) syndrome?
Which of the following electrolyte abnormalities would be associated with hypoparathyroidism, a feature of 22q11 deletion (DiGeorge) syndrome?
