General and Systemic Pathology: Non-Neoplastic Glomerular Diseases
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Questions and Answers

What is the typical time frame between the onset of symptoms and the recovery from a sore throat in patients with this condition?

  • 4-6 weeks
  • 1-2 days
  • 1-2 weeks (correct)
  • 2-4 weeks
  • What is the typical outcome for patients with this condition who receive conservative therapy?

  • 90% recover renal function
  • 85% recover renal function
  • 95% recover renal function (correct)
  • 98% recover renal function
  • What type of deposits are typically seen on Electron Microscopy in this condition?

  • Discrete, Amorphous, Electron-dense deposits on the epithelial side (correct)
  • Granular deposits on the endothelial side
  • Crystalline deposits on the GBM
  • Fibrous deposits on the mesangium
  • What percentage of patients with this condition are expected to have c-ANCA or p-ANCA in their serum?

    <p>90%</p> Signup and view all the answers

    What is a common feature of the urine in patients with this condition?

    <p>Dysmorphic red cells or red cell casts</p> Signup and view all the answers

    Which type of ANCA is a highly sensitive diagnostic marker for pauciimmune crescentic glomerulonephritis?

    <p>MPO-ANCA</p> Signup and view all the answers

    What is a characteristic morphology of kidneys in pauci-immune crescentic glomerulonephritis?

    <p>Petechial hemorrhages on cortical surfaces</p> Signup and view all the answers

    What is the characteristic immunofluorescence pattern in Goodpasture syndrome?

    <p>Linear GBM fluorescence for Ig and complements</p> Signup and view all the answers

    What is the characteristic morphology of glomeruli in pauci-immune RPGN?

    <p>Segmental glomerular necrosis and crescents adjacent to glomerular segments uninvolved by inflammatory or proliferation</p> Signup and view all the answers

    What is the process involved in the formation of crescents?

    <p>Glomerular epithelial cell proliferation and migration of monocytes and macrophages into urinary space</p> Signup and view all the answers

    What is the result of early aggressive therapy in pauci-immune crescentic glomerulonephritis?

    <p>Restoration of normal glomerular architecture</p> Signup and view all the answers

    What is the primary correlation of decline in renal function with?

    <p>extent of tubulointerstitial damage</p> Signup and view all the answers

    Which type of glomerulonephritis is characterized by rapid progression?

    <p>Crescentic Glomerulonephritis</p> Signup and view all the answers

    What is the consequence of damage or loss of the peritubular capillary blood?

    <p>ischemia of tubular segments</p> Signup and view all the answers

    Which of the following is NOT a type of Nephritic Syndrome?

    <p>Membranous Nephropathy</p> Signup and view all the answers

    What is the term for the inflammation in the interstitium adjacent to the tubules?

    <p>interstitial nephritis</p> Signup and view all the answers

    How many types of Nephrotic Syndrome are mentioned in the topic outline?

    <p>5</p> Signup and view all the answers

    What is the role of sensitized T cells in glomerulonephritis?

    <p>They cause glomerular injury and are involved in the progression of some glomerulonephritides</p> Signup and view all the answers

    What is the result of lymphocyte activation on exposure to antigen?

    <p>Glomerular injury</p> Signup and view all the answers

    What is the role of macrophages and T lymphocytes in glomerular injury?

    <p>They produce cytokines and growth factors</p> Signup and view all the answers

    What is the characteristic of membranoproliferative glomerulonephritis type II?

    <p>It is a type of dense-deposit disease</p> Signup and view all the answers

    What is the effect of eicosanoids and nitric oxide on glomerular function?

    <p>They reduce glomerular filtration rate</p> Signup and view all the answers

    What is the role of complement activation in glomerular injury?

    <p>It generates chemotactic products, leading to leukocyte influx and cell lysis</p> Signup and view all the answers

    What is the main function of the collagen monomer in the Glomerular Basement Membrane?

    <p>Forming a network suprastructure to which other glycoproteins attach</p> Signup and view all the answers

    What is the approximate diameter of the endothelial cell fenestra?

    <p>70-100 nm</p> Signup and view all the answers

    What is the primary function of the mesangial cells?

    <p>Contractile, phagocytic, and capable of</p> Signup and view all the answers

    What is the location of the podocytes in the Glomerular Capillary Wall?

    <p>Embedded in and adherent to the lamina rara externa of the Glomerular Basement Membrane</p> Signup and view all the answers

    What is the name of the domain responsible for helix formation and assembly of collagen monomers into the Glomerular Basement Membrane suprastructure?

    <p>NC1 domain</p> Signup and view all the answers

    What is the width of the filtration slits between adjacent foot processes of podocytes?

    <p>20-30 nm</p> Signup and view all the answers

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