General and Systemic Pathology: Non-Neoplastic Glomerular Diseases

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What is the typical time frame between the onset of symptoms and the recovery from a sore throat in patients with this condition?

4-6 weeks
1-2 days
1-2 weeks (correct)
2-4 weeks

What is the typical outcome for patients with this condition who receive conservative therapy?

90% recover renal function
85% recover renal function
95% recover renal function (correct)
98% recover renal function

What type of deposits are typically seen on Electron Microscopy in this condition?

Discrete, Amorphous, Electron-dense deposits on the epithelial side (correct)
Granular deposits on the endothelial side
Crystalline deposits on the GBM
Fibrous deposits on the mesangium

What percentage of patients with this condition are expected to have c-ANCA or p-ANCA in their serum?

90% (B) Signup and view all the answers

What is a common feature of the urine in patients with this condition?

Dysmorphic red cells or red cell casts (D) Signup and view all the answers

Which type of ANCA is a highly sensitive diagnostic marker for pauciimmune crescentic glomerulonephritis?

MPO-ANCA (C) Signup and view all the answers

What is a characteristic morphology of kidneys in pauci-immune crescentic glomerulonephritis?

Petechial hemorrhages on cortical surfaces (A) Signup and view all the answers

What is the characteristic immunofluorescence pattern in Goodpasture syndrome?

Linear GBM fluorescence for Ig and complements (C) Signup and view all the answers

What is the characteristic morphology of glomeruli in pauci-immune RPGN?

Segmental glomerular necrosis and crescents adjacent to glomerular segments uninvolved by inflammatory or proliferation (A) Signup and view all the answers

What is the process involved in the formation of crescents?

Glomerular epithelial cell proliferation and migration of monocytes and macrophages into urinary space (D) Signup and view all the answers

What is the result of early aggressive therapy in pauci-immune crescentic glomerulonephritis?

Restoration of normal glomerular architecture (C) Signup and view all the answers

What is the primary correlation of decline in renal function with?

extent of tubulointerstitial damage (B) Signup and view all the answers

Which type of glomerulonephritis is characterized by rapid progression?

Crescentic Glomerulonephritis (B) Signup and view all the answers

What is the consequence of damage or loss of the peritubular capillary blood?

ischemia of tubular segments (D) Signup and view all the answers

Which of the following is NOT a type of Nephritic Syndrome?

Membranous Nephropathy (C) Signup and view all the answers

What is the term for the inflammation in the interstitium adjacent to the tubules?

interstitial nephritis (A) Signup and view all the answers

How many types of Nephrotic Syndrome are mentioned in the topic outline?

5 (D) Signup and view all the answers

What is the role of sensitized T cells in glomerulonephritis?

They cause glomerular injury and are involved in the progression of some glomerulonephritides (A) Signup and view all the answers

What is the result of lymphocyte activation on exposure to antigen?

Glomerular injury (D) Signup and view all the answers

What is the role of macrophages and T lymphocytes in glomerular injury?

They produce cytokines and growth factors (B) Signup and view all the answers

What is the characteristic of membranoproliferative glomerulonephritis type II?

It is a type of dense-deposit disease (C) Signup and view all the answers

What is the effect of eicosanoids and nitric oxide on glomerular function?

They reduce glomerular filtration rate (A) Signup and view all the answers

What is the role of complement activation in glomerular injury?

It generates chemotactic products, leading to leukocyte influx and cell lysis (D) Signup and view all the answers

What is the main function of the collagen monomer in the Glomerular Basement Membrane?

Forming a network suprastructure to which other glycoproteins attach (A) Signup and view all the answers

What is the approximate diameter of the endothelial cell fenestra?

70-100 nm (A) Signup and view all the answers

What is the primary function of the mesangial cells?

Contractile, phagocytic, and capable of (B) Signup and view all the answers

What is the location of the podocytes in the Glomerular Capillary Wall?

Embedded in and adherent to the lamina rara externa of the Glomerular Basement Membrane (A) Signup and view all the answers

What is the name of the domain responsible for helix formation and assembly of collagen monomers into the Glomerular Basement Membrane suprastructure?

NC1 domain (D) Signup and view all the answers

What is the width of the filtration slits between adjacent foot processes of podocytes?

20-30 nm (D) Signup and view all the answers