General and Systemic Pathology: Endocrine System I

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Questions and Answers

Which organ is primarily responsible for orchestrating equilibrium among various organs in the body?

  • Hypothalamus (correct)
  • Thyroid gland
  • Parathyroid glands
  • Pituitary gland

What type of signaling is classified based on substances acting on surface receptors of adjacent cells?

  • Endocrine
  • Paracrine (correct)
  • Autonomic
  • Autocrine

Which gland is associated with Graves' disease, a common autoimmune disorder?

  • Parathyroid glands
  • Pituitary gland
  • Hypothalamus
  • Thyroid gland (correct)

Which neoplasm is specifically associated with the thyroid gland as mentioned in the text?

<p>Neoplasms of the thyroid (D)</p> Signup and view all the answers

Which condition is characterized by excessive secretion of parathyroid hormone?

<p>Hyperparathyroidism (A)</p> Signup and view all the answers

Which of the following is NOT a common cause of Syndrome of Inappropriate Antidiuretic Hormone?

<p>Drugs that decrease antidiuretic hormone secretion (B)</p> Signup and view all the answers

What is the embryological origin of the thyroid gland?

<p>Endodermal origin (C)</p> Signup and view all the answers

What is the primary function of thyroid follicular epithelial cells?

<p>Conversion of thyroglobulin into thyroxine and triiodothyronine (A)</p> Signup and view all the answers

Which gland is located below and anterior to the larynx?

<p>Thyroid gland (D)</p> Signup and view all the answers

What is the main function of antidiuretic hormone in the body?

<p>Increasing water resorption in the kidneys (D)</p> Signup and view all the answers

What genetic defect leads to combined pituitary hormone deficiency, including growth hormone, prolactin, and thyroid-stimulating hormone?

<p>Mutation of the pituitary-specific gene PIT-1 (B)</p> Signup and view all the answers

Which condition is characterized by excessive urination due to an inability of the kidney to resorb water properly from the urine?

<p>Nephrogenic Diabetes Insipidus (A)</p> Signup and view all the answers

What is the main cause of Diabetes Insipidus resulting from antidiuretic hormone deficiency?

<p>Head Trauma (A)</p> Signup and view all the answers

Which type of diabetes insipidus is a result of renal tubular unresponsiveness to circulating antidiuretic hormone?

<p>Nephrogenic Diabetes Insipidus (C)</p> Signup and view all the answers

What type of disorder may arise spontaneously with no identifiable underlying cause in the hypothalamus and the pituitary gland?

<p>Inflammatory Disorders (B)</p> Signup and view all the answers

Which gland secretes calcitonin?

<p>Thyroid gland (D)</p> Signup and view all the answers

What is the effect of iodide in large doses on individuals with thyroid hyperfunction?

<p>Inhibits the release of thyroid hormones (B)</p> Signup and view all the answers

What is a common cardiac manifestation of hyperthyroidism?

<p>Elevated cardiac contractility and output (D)</p> Signup and view all the answers

Which of the following changes is NOT associated with myocardium in hyperthyroidism?

<p>Decrease in size and number of mitochondria (A)</p> Signup and view all the answers

Which endocrine gland is primarily responsible for regulating the basal metabolic rate?

<p>Thyroid gland (C)</p> Signup and view all the answers

What is the primary effect of thyroid hormone on bone metabolism?

<p>Stimulates bone resorption (B)</p> Signup and view all the answers

Which condition is characterized by an abrupt onset of severe hyperthyroidism?

<p>Thyroid storm (A)</p> Signup and view all the answers

What is the most common trigger for the development of Thyroid Storm?

<p>Infection or surgery (D)</p> Signup and view all the answers

What is the typical presentation of patients with Apathetic Hyperthyroidism?

<p>Unexplained weight loss in older adults (C)</p> Signup and view all the answers

Which laboratory test is considered the most useful single screening test for hyperthyroidism?

<p>Serum Thyroid-Stimulating Hormone concentration (A)</p> Signup and view all the answers

Which transcription factor is responsible for regulating the differentiation of pluripotent stem cells into terminally differentiated cell types in Rathke's pouch?

<p>PIT-1 (B)</p> Signup and view all the answers

Which hormone stimulates the formation of graafian follicles in the ovary?

<p>Follicle-Stimulating Hormone (A)</p> Signup and view all the answers

Which hormone induces ovulation and the formation of corpora lutea in the ovary?

<p>Luteinizing Hormone (D)</p> Signup and view all the answers

Which of the following hormones regulates spermatogenesis and testosterone production in males?

<p>Luteinizing Hormone (D)</p> Signup and view all the answers

Which factor is required for gonadotroph differentiation?

<p>Steroidogenic Factor-1 (B)</p> Signup and view all the answers

What is the main function of the crowded, enlarged epithelial cells in the thyroid follicles as described in the text?

<p>Actively resorb the colloid (D)</p> Signup and view all the answers

Which lymphocytes are predominantly found in the interstitium of the thyroid gland according to the text?

<p>T cells (C)</p> Signup and view all the answers

What is a common characteristic of germinal centers in the thyroid gland as mentioned in the text?

<p>Common occurrence (B)</p> Signup and view all the answers

How does iodine administration affect the thyroid epithelium according to the text?

<p>Causes involution of the epithelium (D)</p> Signup and view all the answers

What does propylthiouracil, an antithyroid drug, do to thyroid epithelium based on the text?

<p>Exaggerates epithelial hypertrophy and hyperplasia (C)</p> Signup and view all the answers

What clinical sign is produced by sympathetic overactivity in Graves' disease?

<p>Exophthalmos (C)</p> Signup and view all the answers

'Infiltrative Dermopathy or Pretibial Myxedema' is most commonly found in which area of the body?

<p>Shins (B)</p> Signup and view all the answers

What is one effect of increased blood flow through a hyperactive gland according to the text?

<p>Visible bruit (B)</p> Signup and view all the answers

What characterizes the ophthalmopathy associated with Graves' disease?

<p>Corneal injury (C)</p> Signup and view all the answers

What is a common manifestation of Graves' disease that can persist despite successful treatment?

<p>Wide, staring gaze (B)</p> Signup and view all the answers

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GSP M.01 Endocrine System I PDF

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