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Questions and Answers
What is the primary factor that allows sperm to travel from the cervix to the uterine tube?
What is the primary factor that allows sperm to travel from the cervix to the uterine tube?
Why is it not advantageous for sperm to reach the ampulla immediately after being deposited in the female reproductive tract?
Why is it not advantageous for sperm to reach the ampulla immediately after being deposited in the female reproductive tract?
What is the role of the corona radiata in fertilization?
What is the role of the corona radiata in fertilization?
What is the primary function of the acrosome reaction?
What is the primary function of the acrosome reaction?
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What is the significance of the zona pellucida in fertilization?
What is the significance of the zona pellucida in fertilization?
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What is the purpose of mitosis in eukaryotic organisms?
What is the purpose of mitosis in eukaryotic organisms?
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How many sperm normally reach the site of fertilization?
How many sperm normally reach the site of fertilization?
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What is the role of the sperm that do not fertilize the egg?
What is the role of the sperm that do not fertilize the egg?
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During which phase of the cell cycle does DNA duplication occur?
During which phase of the cell cycle does DNA duplication occur?
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Which of the following is NOT a phase of fertilization?
Which of the following is NOT a phase of fertilization?
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What is the function of the mitotic spindle during mitosis?
What is the function of the mitotic spindle during mitosis?
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In which phase of mitosis do the sister chromatids separate and move to opposite poles of the cell?
In which phase of mitosis do the sister chromatids separate and move to opposite poles of the cell?
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What is the primary difference between mitosis and meiosis?
What is the primary difference between mitosis and meiosis?
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Which of the following is NOT a characteristic of the interphase stage of mitosis?
Which of the following is NOT a characteristic of the interphase stage of mitosis?
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What is the significance of the centromere in a chromosome?
What is the significance of the centromere in a chromosome?
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Which of the following is NOT a direct consequence of the cell division by mitosis?
Which of the following is NOT a direct consequence of the cell division by mitosis?
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What is the time frame in which the bilaminar disc is formed during human development?
What is the time frame in which the bilaminar disc is formed during human development?
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What is the structure that is responsible for signaling to the overlying ectoderm to thicken and become the neural plate
What is the structure that is responsible for signaling to the overlying ectoderm to thicken and become the neural plate
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During what stage of development does the trophoblast start to invade the endometrium?
During what stage of development does the trophoblast start to invade the endometrium?
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From which layer of the blastocyst does the trophoblast develop?
From which layer of the blastocyst does the trophoblast develop?
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How is the notochord formed?
How is the notochord formed?
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What hormone is produced by the trophoblast cells?
What hormone is produced by the trophoblast cells?
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What is the name of the structure that forms the crests of the neural folds?
What is the name of the structure that forms the crests of the neural folds?
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Which of the following structures is NOT derived from the hypoblast layer?
Which of the following structures is NOT derived from the hypoblast layer?
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What is the name given to the process of formation of the neural tube from a flat sheet of ectoderm?
What is the name given to the process of formation of the neural tube from a flat sheet of ectoderm?
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What is the primary function of the placenta?
What is the primary function of the placenta?
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What is formed from the remainder of the neural plate, after the brain forms?
What is formed from the remainder of the neural plate, after the brain forms?
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Which of the following structures is NOT derived from the neural tube?
Which of the following structures is NOT derived from the neural tube?
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Monozygotic twins that share their amnion are at a higher risk of complications compared to those with separate amniotic sacs. Why is this?
Monozygotic twins that share their amnion are at a higher risk of complications compared to those with separate amniotic sacs. Why is this?
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During which week of gestation does gastrulation occur?
During which week of gestation does gastrulation occur?
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When does the caudal neuropore typically close during neurulation?
When does the caudal neuropore typically close during neurulation?
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Which of the following is a correct description of the relationship between the notochord and the neural plate?
Which of the following is a correct description of the relationship between the notochord and the neural plate?
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Which germ layer gives rise to the muscles of the body?
Which germ layer gives rise to the muscles of the body?
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Which part of the primitive streak gives rise to the paraxial mesoderm?
Which part of the primitive streak gives rise to the paraxial mesoderm?
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Which of the following structures is NOT derived from the endoderm?
Which of the following structures is NOT derived from the endoderm?
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Which of these structures is formed by cells migrating through the most caudal tip of the primitive streak?
Which of these structures is formed by cells migrating through the most caudal tip of the primitive streak?
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Which of these is NOT derived from mesoderm?
Which of these is NOT derived from mesoderm?
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Which germ layer forms the linings of the body cavities?
Which germ layer forms the linings of the body cavities?
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Which of the following is a structure formed by the first cells to migrate towards the cephalic end?
Which of the following is a structure formed by the first cells to migrate towards the cephalic end?
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Which of these layers forms the epidermis of the skin?
Which of these layers forms the epidermis of the skin?
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Which of the following statements accurately describes the acrosome reaction?
Which of the following statements accurately describes the acrosome reaction?
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What is the primary function of the zona reaction?
What is the primary function of the zona reaction?
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What happens immediately after the sperm enters the oocyte?
What happens immediately after the sperm enters the oocyte?
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Which of the following is a direct consequence of fertilization?
Which of the following is a direct consequence of fertilization?
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What is the significance of the interaction between integrins on the oocyte and disintegrins on the sperm?
What is the significance of the interaction between integrins on the oocyte and disintegrins on the sperm?
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Which of the following events directly contribute to the prevention of polyspermy?
Which of the following events directly contribute to the prevention of polyspermy?
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What is the fate of the sperm's plasma membrane during fertilization?
What is the fate of the sperm's plasma membrane during fertilization?
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Which of the following is a direct result of the fusion of sperm and egg plasma membranes?
Which of the following is a direct result of the fusion of sperm and egg plasma membranes?
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Flashcards
Fetal Growth
Fetal Growth
The rapid increase in size, mass, and complexity of the fetus.
Birth Timing
Birth Timing
Birth occurs between 37 and 42 weeks after fertilization.
Mitosis
Mitosis
Process where a maternal cell divides to form two identical daughter cells.
Cell Cycle Phases
Cell Cycle Phases
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Prophase
Prophase
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Metaphase
Metaphase
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Anaphase
Anaphase
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Cytokinesis
Cytokinesis
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Neurulation
Neurulation
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Neural tube
Neural tube
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Notochord
Notochord
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Neural plate
Neural plate
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Cranial neuropore
Cranial neuropore
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Caudal neuropore
Caudal neuropore
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Neural folds
Neural folds
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Neuroectoderm
Neuroectoderm
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Sperm Viability
Sperm Viability
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Cervical Entry
Cervical Entry
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Sperm Movement
Sperm Movement
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Capacitation
Capacitation
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Acrosome Reaction
Acrosome Reaction
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Fertilization Phases
Fertilization Phases
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Penetration of Zona Pellucida
Penetration of Zona Pellucida
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Sperm Count at Fertilization Site
Sperm Count at Fertilization Site
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Primitive streak
Primitive streak
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Primitive node
Primitive node
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Epiblast layer
Epiblast layer
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Mesoderm
Mesoderm
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Endoderm
Endoderm
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Paraxial mesoderm
Paraxial mesoderm
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Intermediate mesoderm
Intermediate mesoderm
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Lateral plate mesoderm
Lateral plate mesoderm
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ZP3
ZP3
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Zona Reaction
Zona Reaction
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Integrins
Integrins
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Cortical Granules
Cortical Granules
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Diploid Number
Diploid Number
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Sister Chromatids
Sister Chromatids
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Metabolic Activation
Metabolic Activation
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Monozygotic Twins
Monozygotic Twins
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Monochorionic vs Diamniotic
Monochorionic vs Diamniotic
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Germ Layers
Germ Layers
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Trophoblast
Trophoblast
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Implantation
Implantation
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Gastrulation
Gastrulation
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Conjoined Twins
Conjoined Twins
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Bilaminar Disc
Bilaminar Disc
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Study Notes
General and Systemic Embryology
- Embryology is the study of prenatal development, from gamete formation to organogenesis, focusing on the development of an embryo.
- This process includes fertilization, cleavage, germ layer formation, organogenesis, and maturation.
- Key developmental studies under Embryology include embryonic development and foetal development.
- Embryonic development encompass all stages from fertilization and cleavage of the zygote to germ layer differentiation and organogenesis/embryogenesis, occurring until the 8th week. During this stage the developing life is termed as an embryo.
- Foetal development, occurring from the 9th week until termination of pregnancy, involves the growth and maturation of the embryo.
Gestation Period
- The gestation period is divided into three stages: germinal, embryonic, and foetal.
- The germinal period starts from the first week to the second week.
- The embryonic period extends from the third week to the eighth week.
- The foetal period spans from the 9th week of pregnancy to the termination of pregnancy.
Time Period: Day 0 to Birth
- The embryonic period lasts from fertilization to the end of the 8th week. During this period the early zygote rapidly proliferates into a ball of cells, which works its way to the uterus.
- External features like eyes, ears and mouth are visible by the end of the 8th week. Finger and toes are formed and limbs have elbow and knee joints by this time.
- The foetal period runs from the 9th week to birth. The foetus grows rapidly in size, mass and complexity, and has changes in proportions. The final stages of organ and system development take place during this time.
- Birth usually happens between 37 and 42 weeks after fertilisation.
Cell Division
- Cell division in eukaryotes typically happens through mitosis. Mitosis creates two genetically identical daughter cells, for growth, repair and cell replacement.
- DNA duplication occurs during the S phase, a part of the cell cycle.
- The phases of mitosis include interphase, prophase, prometaphase, metaphase, anaphase and telophase followed by cytokinesis.
Meiosis
- Meiosis is the method used to produce spermatozoa and ova. It involves two divisions, resulting in four haploid cells from a single diploid cell.
- Human chromosomes: humans have 23 chromosome pairs arranged in 22 pairs of autosomes and one pair of sex chromosomes represented as XX for females and XY for males.
- During meiosis I, homologous chromosomes exchange genetic material (homologous recombination) and then separate, halving the chromosome number.
- During meiosis II, sister chromatids are separated, leading to further reduction. Results in four haploid cells.
Gametogenesis
- Gametogenesis, the process of producing gametes (ova and spermatozoa), is distinct in males and females.
- Phase 1: Origin and Migration of Germ Cells.
- Primordial germ cells, the earliest precursors of gametes, arise outside the gonads and migrate to the gonads. These cells become identifiable after fertilisation.
- Phase 2: Increase in the Number of Germ Cells by Mitosis.
- Mitotic divisions increase the number of germ cells. This differs widely between males and females, and there is a maximum number for females. Oogonia are the germ cells in females which rapidly proliferate in the embryonic ovary during pregnancy. The rapid increase in gamete numbers is followed by atresia or degeneration to achieve the adult number. Spermatogonia are the germ cells in the male.
- Phase 3: Reduction in Chromosomal Number by Meiosis.
- In females, meiosis begins in the fetus, and primary oocytes enter the first meiotic division late in the fetal period. This process is not complete until fertilisation.
- In males, meiosis begins at puberty, and spermatogonia undergo periodic mitotic divisions, continuing throughout a man's reproductive lifespan.
Fertilization
- Fertilization is the fusion of male and female gametes. This process takes place in the ampullary region of the uterine tube close to the ovary.
- Sperm viability in the female tract can last for days.
- Sperm movement is primarily by muscular contractions of the uterine walls and tubes, as opposed to their own individual propulsion
- Capacitation: Sperm must undergo capacitation, a conditioning process.
- Acrosome reaction: Sperm penetration through the corona radiata and zona pellucida requires an acrosome reaction.
- Phases of fertilization:
- Penetration of corona radiata.
- Penetration of zona pellucida.
- Fusion of oocyte and sperm cell membranes.
- Enzymes are released that prevent additional sperm from entering and complete the fertilization of the oocyte.
Cleavage
- Cleavage is a rapid series of mitotic divisions that occur after fertilization.
- The zygote increases in the number of cells but without increasing in size.
- The cells of the zygote are called blastomeres.
- Stages of cleavage: two-cell, 4-cell, 12- to 16-cell, morula, and blastocyst stages.
Morula and Blastocyst
- The morula is a solid ball of cells formed via cleavage.
- The blastocyst is a hollow sphere-shaped structure composed of an inner cell mass (embryoblast) destined to form the embryo and an outer cell layer (trophoblast) destined to form the placenta.
- The zona pellucida usually disintegrates around the 4th day and the blastocyst then begins to implant in the endometrium of the uterus on roughly the 6th–7th day of pregnancy.
Implantation
- Implantation, the process in which the blastocyst burrows into the uterine wall.
- This allows the embryo to obtain nutrients and oxygen from the mother.
- This is usually complete by the end of approximately the 7th day.
Placenta
- The placenta is an organ that forms between the mother and the fetus to exchange nutrients, gases, and wastes.
- It arises from the trophoblast. It connects developing embryo to the uterine wall in the mother.
- hCG is produced by trophoblast during the initial stages of placental formation to maintain the corpus luteum, which promotes hormonal activity
Gastrulation
- Gastrulation is the start of the third week of gestation.
- It involves the formation of the trilaminar germ disc (ectoderm, mesoderm, and endoderm)
- Gastrulation begins with the appearance of the primitive streak on the surface of the epiblast.
- Epiblast cells migrate to the primitive pit, beneath the epiblast layer to form the endodermal layer.
- These germ layers give rise to various tissues and organs.
Neurulation
- Neurulation is a process that occurs during the third week of gestation.
- It involves the formation of the neural tube from the neural plate, which goes on to form the central nervous system (spinal cord and brain).
- The neural tube arises from the neuroectoderm, where neuroectodermal cells from the epiblast migrate to the notochordal process to form the notochord.
Development of the central nervous system (somites)
- Somites are the blocks of tissues that develop on either side of the notochord to form the axial skeleton.
- The central nervous system, as well as parts of the heart and other organs, forms from the neural crest cells, which have the ability to migrate extensively. Neural crest cells are part of the neuroectodermal formation (from the neural plate).
Twins
- Twinning occurs in two ways, dizygotic (fraternal) twins- resulting from the fertilization of two different ova by two different sperm, or monozygotic (identical) twins – arise when a single zygote splits into two separate masses of cells.
Clinical Relevance
- Neural crest cell migration defects affect various structures.
- Failure of the neural tube to close in the foetal period may result in spina bifida and anencephaly.
- Waardenburg syndrome is a genetic condition that affects multiple structures (including pigmentation, eyes, nose, hair and inner ear)
- DiGeorge syndrome is a genetic disorder characterized by congenital abnormalities impacting several structures (heart, circulatory, immune and developmental organs)
- Also includes a variety of defects to organ systems.
Time Periods: Day 21 to Week 8 (body cavities)
- Formation of body cavities involving the intra-embryonic cavity.
- These cavities are further separated by the septum transversum which divides to form the thoracic and abdominal cavities.
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Description
Test your knowledge on the stages of embryological development and the gestation period. This quiz covers key concepts such as fertilization, organogenesis, and the differences between embryonic and foetal development. Perfect for students of biological sciences!