General and Systemic Embryology Quiz
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Questions and Answers

What is the primary factor that allows sperm to travel from the cervix to the uterine tube?

  • Sperm's own propulsion
  • Gravity
  • Muscular contractions of the uterus and uterine tube (correct)
  • Fluid currents in the reproductive tract
  • Why is it not advantageous for sperm to reach the ampulla immediately after being deposited in the female reproductive tract?

  • The sperm will be too fatigued to fertilize the egg.
  • Too many sperm reaching the ampulla will lead to competition and decrease the chances of fertilization.
  • The sperm must undergo capacitation before they can fertilize the egg. (correct)
  • The egg may not be receptive to fertilization yet.
  • What is the role of the corona radiata in fertilization?

  • It provides nutrients to the egg.
  • It creates a barrier that only capacitated sperm can pass through. (correct)
  • It helps to facilitate sperm binding and induces the acrosome reaction.
  • It protects the egg from infection.
  • What is the primary function of the acrosome reaction?

    <p>To release enzymes that help sperm penetrate the zona pellucida. (B)</p> Signup and view all the answers

    What is the significance of the zona pellucida in fertilization?

    <p>It prevents multiple sperm from entering the egg. (C)</p> Signup and view all the answers

    What is the purpose of mitosis in eukaryotic organisms?

    <p>To create new cells for growth, repair, and replacement (C)</p> Signup and view all the answers

    How many sperm normally reach the site of fertilization?

    <p>300 to 500 (C)</p> Signup and view all the answers

    What is the role of the sperm that do not fertilize the egg?

    <p>They aid the fertilizing sperm in penetrating the barriers protecting the female gamete. (C)</p> Signup and view all the answers

    During which phase of the cell cycle does DNA duplication occur?

    <p>S phase (C)</p> Signup and view all the answers

    Which of the following is NOT a phase of fertilization?

    <p>Acrosome reaction (B)</p> Signup and view all the answers

    What is the function of the mitotic spindle during mitosis?

    <p>To attach to and separate the chromosomes (D)</p> Signup and view all the answers

    In which phase of mitosis do the sister chromatids separate and move to opposite poles of the cell?

    <p>Anaphase (B)</p> Signup and view all the answers

    What is the primary difference between mitosis and meiosis?

    <p>Mitosis results in genetically identical daughter cells, while meiosis results in genetically diverse daughter cells. (D)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of the interphase stage of mitosis?

    <p>Chromosomes are visible under a microscope. (C)</p> Signup and view all the answers

    What is the significance of the centromere in a chromosome?

    <p>It is the site where the chromosomes attach to the mitotic spindle. (C)</p> Signup and view all the answers

    Which of the following is NOT a direct consequence of the cell division by mitosis?

    <p>Production of gametes (sperm and egg cells) (B)</p> Signup and view all the answers

    What is the time frame in which the bilaminar disc is formed during human development?

    <p>Second week of gestation (A)</p> Signup and view all the answers

    What is the structure that is responsible for signaling to the overlying ectoderm to thicken and become the neural plate

    <p>Notochord (B)</p> Signup and view all the answers

    During what stage of development does the trophoblast start to invade the endometrium?

    <p>Around 6-7 days after fertilization (A)</p> Signup and view all the answers

    From which layer of the blastocyst does the trophoblast develop?

    <p>Outer cell mass (A)</p> Signup and view all the answers

    How is the notochord formed?

    <p>From the fusion of the notochordal process and the endoderm (B)</p> Signup and view all the answers

    What hormone is produced by the trophoblast cells?

    <p>Human chorionic gonadotropin (hCG) (D)</p> Signup and view all the answers

    What is the name of the structure that forms the crests of the neural folds?

    <p>Neural Crest (C)</p> Signup and view all the answers

    Which of the following structures is NOT derived from the hypoblast layer?

    <p>Embryo (B)</p> Signup and view all the answers

    What is the name given to the process of formation of the neural tube from a flat sheet of ectoderm?

    <p>Neurulation (D)</p> Signup and view all the answers

    What is the primary function of the placenta?

    <p>All of the above (D)</p> Signup and view all the answers

    What is formed from the remainder of the neural plate, after the brain forms?

    <p>Spinal Cord (B)</p> Signup and view all the answers

    Which of the following structures is NOT derived from the neural tube?

    <p>Notochord (B)</p> Signup and view all the answers

    Monozygotic twins that share their amnion are at a higher risk of complications compared to those with separate amniotic sacs. Why is this?

    <p>The shared amnion increases the risk of entanglement and compression (D)</p> Signup and view all the answers

    During which week of gestation does gastrulation occur?

    <p>Third week (D)</p> Signup and view all the answers

    When does the caudal neuropore typically close during neurulation?

    <p>Day 26 (A)</p> Signup and view all the answers

    Which of the following is a correct description of the relationship between the notochord and the neural plate?

    <p>The notochord signals to the ectoderm, which then forms the neural plate. (C)</p> Signup and view all the answers

    Which germ layer gives rise to the muscles of the body?

    <p>Mesoderm (A)</p> Signup and view all the answers

    Which part of the primitive streak gives rise to the paraxial mesoderm?

    <p>Cranial part (D)</p> Signup and view all the answers

    Which of the following structures is NOT derived from the endoderm?

    <p>Skeletal muscle (D)</p> Signup and view all the answers

    Which of these structures is formed by cells migrating through the most caudal tip of the primitive streak?

    <p>Extra-embryonic mesoderm (D)</p> Signup and view all the answers

    Which of these is NOT derived from mesoderm?

    <p>Nervous system (D)</p> Signup and view all the answers

    Which germ layer forms the linings of the body cavities?

    <p>Mesoderm (A)</p> Signup and view all the answers

    Which of the following is a structure formed by the first cells to migrate towards the cephalic end?

    <p>Prechordal Plate (A)</p> Signup and view all the answers

    Which of these layers forms the epidermis of the skin?

    <p>Ectoderm (A)</p> Signup and view all the answers

    Which of the following statements accurately describes the acrosome reaction?

    <p>The acrosome reaction occurs when the sperm head comes into contact with the zona pellucida, releasing enzymes that break down the zona and allow the sperm to penetrate. (D)</p> Signup and view all the answers

    What is the primary function of the zona reaction?

    <p>To prevent polyspermy, ensuring that only one sperm fertilizes the egg. (D)</p> Signup and view all the answers

    What happens immediately after the sperm enters the oocyte?

    <p>The oocyte resumes the second meiotic division, resulting in the formation of a haploid egg nucleus. (D)</p> Signup and view all the answers

    Which of the following is a direct consequence of fertilization?

    <p>The zygote acquires a new combination of chromosomes, restoring the diploid number. (A)</p> Signup and view all the answers

    What is the significance of the interaction between integrins on the oocyte and disintegrins on the sperm?

    <p>It facilitates the initial adhesion of the sperm to the oocyte, which is essential for subsequent fusion. (A)</p> Signup and view all the answers

    Which of the following events directly contribute to the prevention of polyspermy?

    <p>The cortical reaction, which alters the properties of the zona pellucida. (A)</p> Signup and view all the answers

    What is the fate of the sperm's plasma membrane during fertilization?

    <p>It is left behind on the oocyte surface after the sperm nucleus enters the cytoplasm. (A)</p> Signup and view all the answers

    Which of the following is a direct result of the fusion of sperm and egg plasma membranes?

    <p>The cortical reaction is triggered. (E)</p> Signup and view all the answers

    Flashcards

    Fetal Growth

    The rapid increase in size, mass, and complexity of the fetus.

    Birth Timing

    Birth occurs between 37 and 42 weeks after fertilization.

    Mitosis

    Process where a maternal cell divides to form two identical daughter cells.

    Cell Cycle Phases

    Includes G1, S, and G2 phases where DNA is prepared and duplicated.

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    Prophase

    First stage of mitosis where DNA condenses into visible chromosomes.

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    Metaphase

    Stage of mitosis where chromosomes align in the middle of the cell.

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    Anaphase

    Stage where chromosome pairs split and move to opposite ends of the cell.

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    Cytokinesis

    The final step of cell division where the cell splits into two daughter cells.

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    Neurulation

    The process of forming the neural tube from ectoderm between days 18-28.

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    Neural tube

    A structure formed from the neural plate that eventually develops into the brain and spinal cord.

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    Notochord

    A rod-like structure formed during embryonic development, serving as a signaling center.

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    Neural plate

    A thickened region of ectoderm overlying the notochord that gives rise to the neural tube.

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    Cranial neuropore

    The open end of the neural tube that eventually closes on day 24 of development.

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    Caudal neuropore

    The open end of the neural tube that eventually closes on day 26 of development.

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    Neural folds

    The sides of the neural groove that come together to form the neural tube.

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    Neuroectoderm

    Cells from the ectoderm that become the neural plate and eventually the neural tube.

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    Sperm Viability

    Sperm can survive in the female tract for several days.

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    Cervical Entry

    Only 1% of sperm reach the cervix after being deposited in the vagina.

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    Sperm Movement

    Sperm move through muscular contractions, not just their own propulsion.

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    Capacitation

    Conditioning process for sperm in the female tract lasting about 7 hours.

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    Acrosome Reaction

    Occurs after sperm bind to zona pellucida, releasing essential enzymes.

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    Fertilization Phases

    Involves three phases: penetration of corona radiata, zona pellucida, and membrane fusion.

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    Penetration of Zona Pellucida

    Glycoprotein shell that maintains sperm binding and induces acrosome reaction.

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    Sperm Count at Fertilization Site

    Out of 200-300 million sperm, only 300-500 reach fertilization site; typically only one fertilizes the egg.

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    Primitive streak

    A depression on the epiblastic surface where cell migration occurs in the embryo.

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    Primitive node

    A mound of cells at the cephalic end of the primitive streak, surrounding the primitive pit.

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    Epiblast layer

    The layer of cells from which the ectodermal layer is formed during development.

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    Mesoderm

    The middle layer of the embryo responsible for forming muscles, bones, and connective tissues.

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    Endoderm

    The innermost layer that develops into the gastrointestinal tract and associated organs.

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    Paraxial mesoderm

    Cells migrating through the lateral part of the primitive node responsible for forming structures such as somites.

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    Intermediate mesoderm

    Cells that migrate through the mid-streak level, contributing to structures like kidneys and gonads.

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    Lateral plate mesoderm

    Cells from the caudal part of the streak that contribute to body cavities and circulatory system.

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    ZP3

    A zona protein that mediates binding and acrosome reaction.

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    Zona Reaction

    Changes in zona pellucida to prevent further sperm entry.

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    Integrins

    Proteins on the oocyte that interact with sperm ligands.

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    Cortical Granules

    Contain lysosomal enzymes that alter zona properties.

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    Diploid Number

    Total count of chromosomes from both parents in a zygote.

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    Sister Chromatids

    Identical copies of a chromosome formed during DNA replication.

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    Metabolic Activation

    Process that triggers egg metabolism after sperm entry.

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    Monozygotic Twins

    Twins formed from a single fertilized egg that splits into two embryos.

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    Monochorionic vs Diamniotic

    Monozygotic twins can share a placenta (monochorionic) but have separate amniotic sacs (diamniotic).

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    Germ Layers

    Three layers (ectoderm, mesoderm, endoderm) formed during gastrulation from the trilaminar disc.

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    Trophoblast

    Outer layer of the blastocyst that forms the placenta and produces hCG.

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    Implantation

    Process where the blastocyst embeds into the uterine lining, initiated by the trophoblast.

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    Gastrulation

    The process occurring in the third week of gestation that forms the trilaminar disc.

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    Conjoined Twins

    Twins that result from incomplete splitting of the zygote after 12 days of fertilization.

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    Bilaminar Disc

    Structure consisting of two layers: epiblast and hypoblast, formed by day 8 post-fertilization.

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    Study Notes

    General and Systemic Embryology

    • Embryology is the study of prenatal development, from gamete formation to organogenesis, focusing on the development of an embryo.
    • This process includes fertilization, cleavage, germ layer formation, organogenesis, and maturation.
    • Key developmental studies under Embryology include embryonic development and foetal development.
    • Embryonic development encompass all stages from fertilization and cleavage of the zygote to germ layer differentiation and organogenesis/embryogenesis, occurring until the 8th week. During this stage the developing life is termed as an embryo.
    • Foetal development, occurring from the 9th week until termination of pregnancy, involves the growth and maturation of the embryo.

    Gestation Period

    • The gestation period is divided into three stages: germinal, embryonic, and foetal.
    • The germinal period starts from the first week to the second week.
    • The embryonic period extends from the third week to the eighth week.
    • The foetal period spans from the 9th week of pregnancy to the termination of pregnancy.

    Time Period: Day 0 to Birth

    • The embryonic period lasts from fertilization to the end of the 8th week. During this period the early zygote rapidly proliferates into a ball of cells, which works its way to the uterus.
    • External features like eyes, ears and mouth are visible by the end of the 8th week. Finger and toes are formed and limbs have elbow and knee joints by this time.
    • The foetal period runs from the 9th week to birth. The foetus grows rapidly in size, mass and complexity, and has changes in proportions. The final stages of organ and system development take place during this time.
    • Birth usually happens between 37 and 42 weeks after fertilisation.

    Cell Division

    • Cell division in eukaryotes typically happens through mitosis. Mitosis creates two genetically identical daughter cells, for growth, repair and cell replacement.
    • DNA duplication occurs during the S phase, a part of the cell cycle.
    • The phases of mitosis include interphase, prophase, prometaphase, metaphase, anaphase and telophase followed by cytokinesis.

    Meiosis

    • Meiosis is the method used to produce spermatozoa and ova. It involves two divisions, resulting in four haploid cells from a single diploid cell.
    • Human chromosomes: humans have 23 chromosome pairs arranged in 22 pairs of autosomes and one pair of sex chromosomes represented as XX for females and XY for males.
    • During meiosis I, homologous chromosomes exchange genetic material (homologous recombination) and then separate, halving the chromosome number.
    • During meiosis II, sister chromatids are separated, leading to further reduction. Results in four haploid cells.

    Gametogenesis

    • Gametogenesis, the process of producing gametes (ova and spermatozoa), is distinct in males and females.
    • Phase 1: Origin and Migration of Germ Cells.
    • Primordial germ cells, the earliest precursors of gametes, arise outside the gonads and migrate to the gonads. These cells become identifiable after fertilisation.
    • Phase 2: Increase in the Number of Germ Cells by Mitosis.
    • Mitotic divisions increase the number of germ cells. This differs widely between males and females, and there is a maximum number for females. Oogonia are the germ cells in females which rapidly proliferate in the embryonic ovary during pregnancy. The rapid increase in gamete numbers is followed by atresia or degeneration to achieve the adult number. Spermatogonia are the germ cells in the male.
    • Phase 3: Reduction in Chromosomal Number by Meiosis.
    • In females, meiosis begins in the fetus, and primary oocytes enter the first meiotic division late in the fetal period. This process is not complete until fertilisation.
    • In males, meiosis begins at puberty, and spermatogonia undergo periodic mitotic divisions, continuing throughout a man's reproductive lifespan.

    Fertilization

    • Fertilization is the fusion of male and female gametes. This process takes place in the ampullary region of the uterine tube close to the ovary.
    • Sperm viability in the female tract can last for days.
    • Sperm movement is primarily by muscular contractions of the uterine walls and tubes, as opposed to their own individual propulsion
    • Capacitation: Sperm must undergo capacitation, a conditioning process.
    • Acrosome reaction: Sperm penetration through the corona radiata and zona pellucida requires an acrosome reaction.
    • Phases of fertilization:
      • Penetration of corona radiata.
      • Penetration of zona pellucida.
      • Fusion of oocyte and sperm cell membranes.
    • Enzymes are released that prevent additional sperm from entering and complete the fertilization of the oocyte.

    Cleavage

    • Cleavage is a rapid series of mitotic divisions that occur after fertilization.
    • The zygote increases in the number of cells but without increasing in size.
    • The cells of the zygote are called blastomeres.
    • Stages of cleavage: two-cell, 4-cell, 12- to 16-cell, morula, and blastocyst stages.

    Morula and Blastocyst

    • The morula is a solid ball of cells formed via cleavage.
    • The blastocyst is a hollow sphere-shaped structure composed of an inner cell mass (embryoblast) destined to form the embryo and an outer cell layer (trophoblast) destined to form the placenta.
    • The zona pellucida usually disintegrates around the 4th day and the blastocyst then begins to implant in the endometrium of the uterus on roughly the 6th–7th day of pregnancy.

    Implantation

    • Implantation, the process in which the blastocyst burrows into the uterine wall.
    • This allows the embryo to obtain nutrients and oxygen from the mother.
    • This is usually complete by the end of approximately the 7th day.

    Placenta

    • The placenta is an organ that forms between the mother and the fetus to exchange nutrients, gases, and wastes.
    • It arises from the trophoblast. It connects developing embryo to the uterine wall in the mother.
    • hCG is produced by trophoblast during the initial stages of placental formation to maintain the corpus luteum, which promotes hormonal activity

    Gastrulation

    • Gastrulation is the start of the third week of gestation.
    • It involves the formation of the trilaminar germ disc (ectoderm, mesoderm, and endoderm)
    • Gastrulation begins with the appearance of the primitive streak on the surface of the epiblast.
    • Epiblast cells migrate to the primitive pit, beneath the epiblast layer to form the endodermal layer.
    • These germ layers give rise to various tissues and organs.

    Neurulation

    • Neurulation is a process that occurs during the third week of gestation.
    • It involves the formation of the neural tube from the neural plate, which goes on to form the central nervous system (spinal cord and brain).
    • The neural tube arises from the neuroectoderm, where neuroectodermal cells from the epiblast migrate to the notochordal process to form the notochord.

    Development of the central nervous system (somites)

    • Somites are the blocks of tissues that develop on either side of the notochord to form the axial skeleton.
    • The central nervous system, as well as parts of the heart and other organs, forms from the neural crest cells, which have the ability to migrate extensively. Neural crest cells are part of the neuroectodermal formation (from the neural plate).

    Twins

    • Twinning occurs in two ways, dizygotic (fraternal) twins- resulting from the fertilization of two different ova by two different sperm, or monozygotic (identical) twins – arise when a single zygote splits into two separate masses of cells.

    Clinical Relevance

    • Neural crest cell migration defects affect various structures.
    • Failure of the neural tube to close in the foetal period may result in spina bifida and anencephaly.
    • Waardenburg syndrome is a genetic condition that affects multiple structures (including pigmentation, eyes, nose, hair and inner ear)
    • DiGeorge syndrome is a genetic disorder characterized by congenital abnormalities impacting several structures (heart, circulatory, immune and developmental organs)
    • Also includes a variety of defects to organ systems.

    Time Periods: Day 21 to Week 8 (body cavities)

    • Formation of body cavities involving the intra-embryonic cavity.
    • These cavities are further separated by the septum transversum which divides to form the thoracic and abdominal cavities.

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    Description

    Test your knowledge on the stages of embryological development and the gestation period. This quiz covers key concepts such as fertilization, organogenesis, and the differences between embryonic and foetal development. Perfect for students of biological sciences!

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