Gemfibrozil (Lopid) Flashcards

Questions and Answers

What is the therapeutic class of Gemfibrozil?

Anticoagulant

Antihyperlipidemic (correct)

Antibiotic

Antihypertensive

What is the pharmacologic class of Gemfibrozil?

Fabric acid agent (Fibrate)

What are the actions of Gemfibrozil?

Unknown how it happens

What are the uses of Gemfibrozil?

50% reduction in VLDL and increase in HDL Signup and view all the answers

What are the administration alerts for Gemfibrozil?

Take with meals to decrease GI distress; preg cat B Signup and view all the answers

What are the adverse effects of Gemfibrozil?

Few; increase gallstone, affect liver function; GI related: dyspepsia, diarrhea, nausea, cramping Signup and view all the answers

What is a contraindication for using Gemfibrozil?

Hepatic impairment; severe renal dysfunction; pre-existing gallbladder disease Signup and view all the answers

What are the drug-drug interactions with Gemfibrozil?

Concurrent use with statins should be avoided; increases effects of anti-diabetic agents, statins, sulfonylureas, vitamin K antagonists Signup and view all the answers

How do fatty foods affect Gemfibrozil efficacy?

Fatty food may decrease efficacy of Gemfibrozil Signup and view all the answers

What is the treatment for a Gemfibrozil overdose?

No specific treatment for overdose Signup and view all the answers

Study Notes

Gemfibrozil Overview

Therapeutic class: Antihyperlipidemic, used to manage lipid levels
Pharmacologic class: Fabric acid agent (Fibrate) targeting lipid metabolism

Mechanism of Action

Mechanism of action is not fully understood; still under investigation

Clinical Uses

Reduces Very Low-Density Lipoprotein (VLDL) by approximately 50%
Increases High-Density Lipoprotein (HDL), enhancing heart health

Administration Guidelines

Recommended to take with meals to minimize gastrointestinal distress
Classified as pregnancy category B, indicating no known risk in humans

Adverse Effects

Generally well-tolerated with few side effects
Potential risks include increased gallstone formation and liver impairment
Common gastrointestinal issues: dyspepsia, diarrhea, nausea, and abdominal cramping

Contraindications

Not advised for individuals with hepatic impairment or severe renal dysfunction
Should be avoided in patients with pre-existing gallbladder disease

Drug Interactions

Concurrent use with statins is discouraged due to heightened risk of myopathy and rhabdomyolysis
May enhance effects of antidiabetic agents, statins, sulfonylureas, and vitamin K antagonists

Dietary Considerations

High-fat meals may reduce the efficacy of gemfibrozil, affecting treatment outcomes

Overdose Management

No specific treatment protocol established for overdose cases

Description

This quiz provides key flashcards related to the drug Gemfibrozil, known as Lopid. Each card covers important aspects such as its therapeutic and pharmacologic classes, actions, uses, and administration alerts. Perfect for students in pharmacology or healthcare fields.