Gelatin in Capsule Production

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Questions and Answers

What characteristic does bone gelatin contribute to the blend used for capsule production?

  • Clarity
  • Firmness (correct)
  • Plasticity
  • Haze reduction

How does pork skin gelatin affect the final product in terms of visual quality?

  • It makes the product less durable.
  • It enhances the haze.
  • It increases brittleness.
  • It contributes to clarity. (correct)

Which extraction technique is utilized for creating 'acid-bone' gelatin?

  • Fermentation
  • Cold extraction
  • Acid extraction (correct)
  • High-temperature extraction

What is the pH range of the gelatin obtained from acid bone extraction?

<p>5.5-6.0 (D)</p> Signup and view all the answers

What is a common characteristic of the gelatins from green bones compared to aged bones?

<p>Indistinguishable in practical use (C)</p> Signup and view all the answers

Which additional specifications are required for gelatin used in capsule production?

<p>Bloom strength, viscosity, and iron content (A)</p> Signup and view all the answers

What disadvantage is associated with bone gelatin in capsule production?

<p>It tends to be hazy and brittle. (D)</p> Signup and view all the answers

What is one of the main benefits of using the acid extraction technique on bones?

<p>Decreased extraction time required (C)</p> Signup and view all the answers

Flashcards

Hard Capsule Gelatin

Blends of bone and pork skin gelatin used for hard capsule production, offering toughness and clarity.

Bone Gelatin

A tough, firm, but potentially hazy and brittle gelatin derived from bones.

Pork Skin Gelatin

Adds plasticity and clarity to the blend reducing haze in hard capsules.

Green Bone Gelatin

Type B gelatin made from fresh bones, processed similarly to aged bone gelatin.

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Acid-Bone Gelatin

Gelatin from bones, prepared using acid extraction, offering intermediate film characteristics and faster extraction.

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USP Grade Gelatin

Gelatin meeting the United States Pharmacopeia standards, with additional requirements from capsule manufacturers.

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Bloom Strength

A measurement of gelatin's ability to form a gel.

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Viscosity

The thickness or resistance to flow of the gelatin.

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Iron Content

The amount of iron present in the gelatin.

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Study Notes

Gelatin Blends for Capsule Production

  • High gel strength blends of bone and pork skin gelatin are used for hard capsule production.
  • Bone gelatin forms a tough, firm, but hazy and brittle film.
  • Pork skin gelatin adds plasticity and clarity, reducing haze in capsules.

Recent Gelatin Developments

  • "Green" (fresh) bones are now commercially used for Type B gelatin production.
  • Processing is similar to aged bone gelatin, resulting in indistinguishable final products.
  • Acid-bone gelatin, prepared from bone using acid extraction, is a newer development.
  • Acid-bone gelatin shows an altered isoelectric point (pH 5.5-6.0) and intermediate film characteristics.
  • Acid extraction reduces gelatin processing time.

Gelatin Specifications

  • Gelatin used is USP grade.
  • Additional specifications are required by capsule manufacturers, concerning Bloom strength, viscosity, and iron content.

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