Gastrointestinal Pharmacology: Inflammatory Bowel Disease
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Questions and Answers

What is the primary limitation of ulcerative colitis?

  • It is limited to the colon (correct)
  • It is a patchy transmural inflammation
  • It can affect any part of the GI tract
  • It causes only abdominal pain

    • What is the primary goal of Inflammatory Bowel Disease treatment?

  • To reduce the risk of colorectal cancer
  • To cure the disease
  • To resolve chronic symptoms
  • To resolve acute episodes and prolong remission (correct)

    • What is the mechanism of action of corticosteroids in Inflammatory Bowel Disease?

  • Expression of pro-inflammatory proteins
  • Inhibition of inflammatory pathways (correct)
  • Enhancement of arachidonic acid metabolism
  • Stimulation of inflammatory pathways

    • What is the primary indication for Infliximab in Inflammatory Bowel Disease?

    <p>Active and chronic symptoms refractory to corticosteroids</p> Signup and view all the answers

    What is the potential benefit of Aminosalicylates in Inflammatory Bowel Disease?

    <p>Reduction of risk of colorectal cancer</p> Signup and view all the answers

    What is the primary precaution when using Aminosalicylates in Inflammatory Bowel Disease?

    <p>Caution in renal impairment, pregnancy, and breast feeding</p> Signup and view all the answers

    What is the probable cause of diarrhea due to toxins?

    <p>All of the above</p> Signup and view all the answers

    What is the primary mechanism of action of anti-diarrheal agents?

    <p>Reduce peristalsis by stimulating opioid receptors</p> Signup and view all the answers

    What is the contraindication for diphenoxylate/atropine?

    <p>All of the above</p> Signup and view all the answers

    What is the primary cause of antibiotic-associated diarrhea (AAD)?

    <p>Clostridium difficile</p> Signup and view all the answers

    What is the mechanism of action of simethicone?

    <p>Alters elasticity of mucus-coated bubbles</p> Signup and view all the answers

    What is the site of stimulation for antiemetics like scopolamine?

    <p>Area postrema</p> Signup and view all the answers

    What is the side effect of phenothiazines?

    <p>All of the above</p> Signup and view all the answers

    What is the therapeutic site of action for ondansetron?

    <p>Serotonin 5-HT3 receptors</p> Signup and view all the answers

    What is the primary indication for treatment of diarrhea?

    <p>All of the above</p> Signup and view all the answers

    What is the site of colonization of Clostridium difficile?

    <p>Distal aspect of the colon</p> Signup and view all the answers

    What is the mechanism of action of Azathioprine?

    <p>Inhibition of ribonucleotide synthesis</p> Signup and view all the answers

    What is the primary adverse effect of Cyclosporin?

    <p>Renal impairment</p> Signup and view all the answers

    What is the mechanism of action of Infliximab?

    <p>Inhibition of TNF-α</p> Signup and view all the answers

    What is the primary goal of treatment for constipation?

    <p>To increase bowel content and volume</p> Signup and view all the answers

    What type of laxatives are effective in 1-3 hours and are used to purge the intestine?

    <p>Osmotic laxatives</p> Signup and view all the answers

    What is the primary cause of constipation in laxative abuse?

    <p>Enteral loss of water and salts</p> Signup and view all the answers

    What is the effect of Lubiprostone on the gut?

    <p>It stimulates chloride channels, producing chloride-rich secretions</p> Signup and view all the answers

    What is the common adverse effect of Methotrexate?

    <p>Hepatotoxicity</p> Signup and view all the answers

    What is the role of NFAT proteins in the regulation of T-cell activation?

    <p>They are involved in the transcription of interleukin 2</p> Signup and view all the answers

    What is the common side effect of Thiopurines?

    <p>Flu-like symptoms</p> Signup and view all the answers

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