Gastrointestinal Disorders II: Gastric Acid Secretion and Treatment

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Which receptor is targeted by ondansetron and granisetron?

5-HT3 receptor

What is the mechanism of action of chlorpromazine and prochlorperazine in treating vomiting?

Antagonizing 5-HT3 receptor

What triggers the release of mediators like 5-HT from enterochromaffin cells in the GI tract, leading to vagal afferent signaling?

Toxins

Which type of receptor does alosetron primarily affect?

<p>5-HT3 receptor</p> Signup and view all the answers

What is the primary mechanism of action of chlorpromazine in treating severe nausea and vomiting?

<p>D2 receptor antagonist</p> Signup and view all the answers

Which medication is primarily an H1 receptor antagonist and is used for motion sickness and pregnancy-associated vomiting?

<p>Promethazine</p> Signup and view all the answers

What is the main mechanism of action of domperidone in gastrointestinal disorders?

<p>Increases GI motility</p> Signup and view all the answers

Which class of drugs primarily block substance P signalling in treating gastrointestinal disorders?

<p>NK1 receptor antagonists</p> Signup and view all the answers

What can release mediators like 5-HT from enterochromaffin cells, triggering vagal afferent signalling leading to vomiting and nausea?

<p>Toxins</p> Signup and view all the answers

Which class of drugs acts as a competitive antagonist of all H2 receptors?

<p>H2 receptor antagonists</p> Signup and view all the answers

Which antidiarrheal agent acts directly on enterochromaffin-like cells and stimulates mucin secretion?

<p>Mucosa protectants</p> Signup and view all the answers

Which antidiarrheal agent is known to cause gynaecomastia and reduce cAMP levels?

<p>Cimetidine</p> Signup and view all the answers

Which antidiarrheal agent is indicated to avoid during pregnancy due to its potential to stimulate uterine contractions?

<p>Misoprostol</p> Signup and view all the answers

Which antidiarrheal agent is an analogue of prostaglandin E1 and promotes healing of ulcers?

<p>Misoprostol</p> Signup and view all the answers

Which antidiarrheal agent is known to irreversibly bind to the proton pump and stop H+ movement into the stomach lumen?

<p>Omeprazole</p> Signup and view all the answers

Which antidiarrheal agent can chelate and inhibit absorption of other drugs, and should be avoided for patients with impaired renal function?

<p>Bismuth chelate</p> Signup and view all the answers

Which antidiarrheal agent acts by neutralizing acids to inhibit the activity of peptic enzymes and promote healing of ulcers?

<p>Sucralfate</p> Signup and view all the answers

Which antidiarrheal agent can be taken with simeticone to reduce bloating?

<p>Bismuth chelate</p> Signup and view all the answers

Which antidiarrheal agent stimulates bicarbonate secretion and prevents gastric damage due to chronic NSAID use?

<p>Misoprostol</p> Signup and view all the answers

Which antidiarrheal agent is a competitive antagonist of all H2 receptors, well absorbed orally, and may cause thrombocytopenia as an adverse effect?

<p>Cimetidine</p> Signup and view all the answers

Which antidiarrheal agent has a short half-life but effects that last 2-3 days, and should be avoided for patients with liver disease or those who are pregnant/breastfeeding?

<p>Lansoprazole</p> Signup and view all the answers

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