Gastrointestinal Disorders II: Gastric Acid Secretion and Treatment
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Questions and Answers

Which receptor is targeted by ondansetron and granisetron?

  • 5-HT3 receptor (correct)
  • D2 receptor
  • Muscarinic receptor
  • H1 receptor
  • What is the mechanism of action of chlorpromazine and prochlorperazine in treating vomiting?

  • Agonizing D2 receptor
  • Activating H1 receptor
  • Blocking muscarinic receptor
  • Antagonizing 5-HT3 receptor (correct)
  • What triggers the release of mediators like 5-HT from enterochromaffin cells in the GI tract, leading to vagal afferent signaling?

  • Antacids
  • Toxins (correct)
  • Antibiotics
  • Opioids
  • Which type of receptor does alosetron primarily affect?

    <p>5-HT3 receptor</p> Signup and view all the answers

    What is the primary mechanism of action of chlorpromazine in treating severe nausea and vomiting?

    <p>D2 receptor antagonist</p> Signup and view all the answers

    Which medication is primarily an H1 receptor antagonist and is used for motion sickness and pregnancy-associated vomiting?

    <p>Promethazine</p> Signup and view all the answers

    What is the main mechanism of action of domperidone in gastrointestinal disorders?

    <p>Increases GI motility</p> Signup and view all the answers

    Which class of drugs primarily block substance P signalling in treating gastrointestinal disorders?

    <p>NK1 receptor antagonists</p> Signup and view all the answers

    What can release mediators like 5-HT from enterochromaffin cells, triggering vagal afferent signalling leading to vomiting and nausea?

    <p>Toxins</p> Signup and view all the answers

    Which class of drugs acts as a competitive antagonist of all H2 receptors?

    <p>H2 receptor antagonists</p> Signup and view all the answers

    Which antidiarrheal agent acts directly on enterochromaffin-like cells and stimulates mucin secretion?

    <p>Mucosa protectants</p> Signup and view all the answers

    Which antidiarrheal agent is known to cause gynaecomastia and reduce cAMP levels?

    <p>Cimetidine</p> Signup and view all the answers

    Which antidiarrheal agent is indicated to avoid during pregnancy due to its potential to stimulate uterine contractions?

    <p>Misoprostol</p> Signup and view all the answers

    Which antidiarrheal agent is an analogue of prostaglandin E1 and promotes healing of ulcers?

    <p>Misoprostol</p> Signup and view all the answers

    Which antidiarrheal agent is known to irreversibly bind to the proton pump and stop H+ movement into the stomach lumen?

    <p>Omeprazole</p> Signup and view all the answers

    Which antidiarrheal agent can chelate and inhibit absorption of other drugs, and should be avoided for patients with impaired renal function?

    <p>Bismuth chelate</p> Signup and view all the answers

    Which antidiarrheal agent acts by neutralizing acids to inhibit the activity of peptic enzymes and promote healing of ulcers?

    <p>Sucralfate</p> Signup and view all the answers

    Which antidiarrheal agent can be taken with simeticone to reduce bloating?

    <p>Bismuth chelate</p> Signup and view all the answers

    Which antidiarrheal agent stimulates bicarbonate secretion and prevents gastric damage due to chronic NSAID use?

    <p>Misoprostol</p> Signup and view all the answers

    Which antidiarrheal agent is a competitive antagonist of all H2 receptors, well absorbed orally, and may cause thrombocytopenia as an adverse effect?

    <p>Cimetidine</p> Signup and view all the answers

    Which antidiarrheal agent has a short half-life but effects that last 2-3 days, and should be avoided for patients with liver disease or those who are pregnant/breastfeeding?

    <p>Lansoprazole</p> Signup and view all the answers

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