Gastrointestinal Disorders Quiz: Zollinger-Ellison Syndrome and Gastric Ulcers

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Which age group is more frequently affected by eosinophilic esophagitis?

Elderly individuals

Adolescents

Young children (correct)

Middle-aged adults

What do adults with eosinophilic esophagitis usually describe?

Feeding difficulties and regurgitation

Abdominal pain and vomiting

Odynophagia and stenosis

Dysphagia and food impaction (correct)

What pathological feature is revealed by endoscopic examination in eosinophilic esophagitis?

Mucosal rings and furrows (correct)

Erythema and dyspepsia

Granularity and feeding difficulties

Vomiting and regurgitation

What is the main microscopic finding in eosinophilic esophagitis?

Marked increase in intraepithelial eosinophils (≥15/hpf) Signup and view all the answers

What causes reflux esophagitis (GERD)?

Reflux of acidic gastric juice into the lower esophagus Signup and view all the answers

What symptoms are often seen in infants and children with eosinophilic esophagitis?

Feeding difficulties, regurgitation, dyspepsia Signup and view all the answers

What is the primary cause of most gastric ulcers?

Decreased resistance to acid Signup and view all the answers

What is the result of erosion of a blood vessel by the ulcer in about 30% of peptic ulcer patients?

Bleeding Signup and view all the answers

What is the cause of celiac disease?

Abnormal sensitivity to gluten Signup and view all the answers

Which test is the first-line test for celiac disease?

Evaluation of titer of IgA anti-tissue transglutaminase (anti-TTG) Signup and view all the answers

Which condition usually affects the terminal ileum and can result in deep transverse ileal ulcers?

Intestinal tuberculosis Signup and view all the answers

What may be required for complications or to obtain tissue for diagnosis in intra-abdominal tuberculosis?

Surgery Signup and view all the answers

What is the primary inflammation pattern seen in Crohn's disease?

Granulomatous Signup and view all the answers

What are the potential long-term complications of celiac disease?

Both A and B Signup and view all the answers

What causes atrophy of small intestinal villi in celiac disease?

Abnormal sensitivity to gluten Signup and view all the answers

What may be present in nearly all patients with chronic duodenal ulcer and approximately 75% of patients with chronic gastric ulcer?

H. pylori infection Signup and view all the answers

What type of ulcerative process may extend through the full thickness of the gut wall into adjacent organ?

Chronic peptic ulcer Signup and view all the answers

What is believed to be the primary cause of peptic ulceration in Zollinger-Ellison syndrome?

High gastrin levels Signup and view all the answers

Which drug can cause a Celiac-like enteropathy that is not responsive to gluten withdrawal from the diet, but disappears after cessation of the drug?

Olmesartan Signup and view all the answers

Which condition is characterized by a lack of normal ganglion cells in the myenteric plexus of part of the bowel?

Hirschsprung's Disease Signup and view all the answers

Which drug can cause a pattern of colitis that can mimic Crohn’s disease?

Mycophenolate Mofetil (CellCept) Signup and view all the answers

What is a condition characterized by protrusion of part of the wall of the rectum into the anal canal, most commonly seen in women?

Solitary rectal ulcer syndrome (Rectal mucosal prolapse syndrome) Signup and view all the answers

What can be identified on biopsy by a characteristic pattern of crypt hyperplasia and congestion, fibrosis, and muscularization of the lamina propria?

Solitary rectal ulcer syndrome (Rectal mucosal prolapse syndrome) Signup and view all the answers

Which group of drugs can cause various patterns of colitis?

NSAID Signup and view all the answers

Which condition is due to the failure of migration of primitive neuroblasts into the developing gut?

Hirschsprung's Disease Signup and view all the answers

1

Solitary rectal ulcer syndrome (Rectal mucosal prolapse syndrome) Signup and view all the answers

What is a potential complication of long-standing ulcerative colitis?

Dysplasia and neoplastic change Signup and view all the answers

Which type of inflammatory bowel disease is associated with non-caseating granulomas in 60% of biopsies?

Crohn's disease Signup and view all the answers

What is a characteristic histological feature of Crohn's disease?

Transmural inflammation with submucosal oedema and ulcers Signup and view all the answers

Where does Crohn's disease particularly affect in the gastrointestinal tract?

The terminal ileum Signup and view all the answers

Which type of inflammatory bowel disease presents with a cobblestone pattern in the bowel mucosa due to submucosal oedema and deep fissured ulcers?

Crohn's disease Signup and view all the answers

What is a potential direct local complication of ulcerative colitis?

Toxic dilatation and perforation of the colon Signup and view all the answers

Which type of inflammatory bowel disease can lead to the formation of fistulas and sinuses, especially in the perianal region?

Crohn's disease Signup and view all the answers

Approximately what percentage of patients with ulcerative colitis have chronic quiescent colitis with infrequent episodes of relapse?

80% Signup and view all the answers

What characterizes the histology of ulcerative colitis during active acute disease?

Shallow ulceration in the mucosa and lamina propria Signup and view all the answers

What is a potential cause of antibiotic-associated colitis?

Overgrowth of Clostridium difficile in the colon following suppression of normal bowel flora by antibiotics Signup and view all the answers

What is a feature of indeterminate colitis?

Non-caseating granulomas present in biopsies Signup and view all the answers

Which condition is characterized by hyperplasia of the basal cells of the squamous epithelium to more than 15% of mucosal thickness?

Reflux esophagitis Signup and view all the answers

What is the most common cause of Barrett's esophagus?

Metaplasia of the esophageal epithelium Signup and view all the answers

What is the main difference between the rolling type and sliding type of hiatal hernia?

Loss of normal cardioesophageal angle Signup and view all the answers

Which factor is associated with acute erosive gastropathy?

NSAIDs Signup and view all the answers

What type of chronic gastritis is primarily associated with Helicobacter pylori infection?

Type B Signup and view all the answers

Which condition results from failure of vitamin B12 absorption caused by lack of intrinsic factor due to autoimmune chronic gastritis?

Pernicious anemia Signup and view all the answers

What is the most common cause of acute erosive gastropathy?

Ethyl alcohol Signup and view all the answers

Which type of hiatal hernia is characterized by herniation of the gastric cardia into the thorax alongside the normal esophagus?

Rolling type Signup and view all the answers

What is the characteristic appearance of acute erosive gastropathy endoscopically?

Diffuse hyperemia of the mucosa with multiple small, superficial erosions and ulcers. Signup and view all the answers

Which condition is characterized by protrusion of part of the stomach through the diaphragmatic hiatus?

Hiatal hernia Signup and view all the answers

What are the three serum autoantibodies associated with autoimmune chronic gastritis?

Anti-parietal cell antibody, anti-intrinsic factor antibody, anti-gastric mucosa antibody Signup and view all the answers

What is the most common cause of type B chronic gastritis?

H. pylori infection Signup and view all the answers

What is the functional result of failure of secretion of acid in autoimmune chronic gastritis?

Increase in serum gastrin level Signup and view all the answers

What is the main histologic finding in patients with reactive gastropathy?

Foveolar hyperplasia and corkscrew appearance of gastric pits Signup and view all the answers

What is a common cause of reactive gastropathy?

Chronic aspirin or NSAID use Signup and view all the answers

What is the main difference in the preferred site of involvement between type A and type B chronic gastritis?

Type A involves the antrum, type B involves the fundic and body mucosa Signup and view all the answers

What is the risk associated with type B chronic gastritis?

Increased risk of gastric adenocarcinoma Signup and view all the answers

What is the putative cause for reactive gastropathy?

Chronic alcohol intake Signup and view all the answers

What can be seen in early cases of type B chronic gastritis?

Lymphoplasmacytic infiltration in the superficial gastric mucosa Signup and view all the answers

What is a notable finding in patients with autoimmune chronic gastritis?

High-grade dysplasia in biopsy specimen Signup and view all the answers

Gastrointestinal Disorders Quiz: Zollinger-Ellison Syndrome and Gastric Ulcers

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Questions and Answers

Which age group is more frequently affected by eosinophilic esophagitis?

What do adults with eosinophilic esophagitis usually describe?

What pathological feature is revealed by endoscopic examination in eosinophilic esophagitis?

What is the main microscopic finding in eosinophilic esophagitis?

What causes reflux esophagitis (GERD)?

What symptoms are often seen in infants and children with eosinophilic esophagitis?

What is the primary cause of most gastric ulcers?

What is the result of erosion of a blood vessel by the ulcer in about 30% of peptic ulcer patients?

What is the cause of celiac disease?

Which test is the first-line test for celiac disease?

Which condition usually affects the terminal ileum and can result in deep transverse ileal ulcers?

What may be required for complications or to obtain tissue for diagnosis in intra-abdominal tuberculosis?

What is the primary inflammation pattern seen in Crohn's disease?

What are the potential long-term complications of celiac disease?

What causes atrophy of small intestinal villi in celiac disease?

What may be present in nearly all patients with chronic duodenal ulcer and approximately 75% of patients with chronic gastric ulcer?

What type of ulcerative process may extend through the full thickness of the gut wall into adjacent organ?

What is believed to be the primary cause of peptic ulceration in Zollinger-Ellison syndrome?

Which drug can cause a Celiac-like enteropathy that is not responsive to gluten withdrawal from the diet, but disappears after cessation of the drug?

Which condition is characterized by a lack of normal ganglion cells in the myenteric plexus of part of the bowel?

Which drug can cause a pattern of colitis that can mimic Crohn’s disease?

What is a condition characterized by protrusion of part of the wall of the rectum into the anal canal, most commonly seen in women?

What can be identified on biopsy by a characteristic pattern of crypt hyperplasia and congestion, fibrosis, and muscularization of the lamina propria?

Which group of drugs can cause various patterns of colitis?

Which condition is due to the failure of migration of primitive neuroblasts into the developing gut?

1

What is a potential complication of long-standing ulcerative colitis?

Which type of inflammatory bowel disease is associated with non-caseating granulomas in 60% of biopsies?

What is a characteristic histological feature of Crohn's disease?

Where does Crohn's disease particularly affect in the gastrointestinal tract?

Which type of inflammatory bowel disease presents with a cobblestone pattern in the bowel mucosa due to submucosal oedema and deep fissured ulcers?

What is a potential direct local complication of ulcerative colitis?

Which type of inflammatory bowel disease can lead to the formation of fistulas and sinuses, especially in the perianal region?

Approximately what percentage of patients with ulcerative colitis have chronic quiescent colitis with infrequent episodes of relapse?

What characterizes the histology of ulcerative colitis during active acute disease?

What is a potential cause of antibiotic-associated colitis?

What is a feature of indeterminate colitis?

Which condition is characterized by hyperplasia of the basal cells of the squamous epithelium to more than 15% of mucosal thickness?

What is the most common cause of Barrett's esophagus?

What is the main difference between the rolling type and sliding type of hiatal hernia?

Which factor is associated with acute erosive gastropathy?

What type of chronic gastritis is primarily associated with Helicobacter pylori infection?

Which condition results from failure of vitamin B12 absorption caused by lack of intrinsic factor due to autoimmune chronic gastritis?

What is the most common cause of acute erosive gastropathy?

Which type of hiatal hernia is characterized by herniation of the gastric cardia into the thorax alongside the normal esophagus?

What is the characteristic appearance of acute erosive gastropathy endoscopically?

Which condition is characterized by protrusion of part of the stomach through the diaphragmatic hiatus?

What are the three serum autoantibodies associated with autoimmune chronic gastritis?

What is the most common cause of type B chronic gastritis?

What is the functional result of failure of secretion of acid in autoimmune chronic gastritis?

What is the main histologic finding in patients with reactive gastropathy?

What is a common cause of reactive gastropathy?

What is the main difference in the preferred site of involvement between type A and type B chronic gastritis?

What is the risk associated with type B chronic gastritis?

What is the putative cause for reactive gastropathy?

What can be seen in early cases of type B chronic gastritis?

What is a notable finding in patients with autoimmune chronic gastritis?

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