Fungal Infections
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Questions and Answers

What is the treatment for Fungemia with catheters?

IV amphotericin B (most broad antifungal). Disseminated infections may require flucytosine or fluconazole.

What are the symptoms and treatment for Hepatosplenic Neutropenia?

Symptoms: Fever, RUQ pain, nausea, increase in alkaline phosphate, low-density defects in the liver, spleen, & kidneys. Treatment: Stable patients can be treated with oral fluconazole, while those with disseminated infections may require IV amphotericin B.

What is the treatment for Endocarditis in patients with IVDU, surgery, and late state HIV?

Treatment includes Amphotericin B for infected valves, which may need to be surgically replaced. Lifelong fluconazole and monitoring of liver function tests (LFTs) are also recommended. Terbinafine may be used cautiously with LFT monitoring.

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