Fungal Infections of Nervous System (MBBS Year 2)
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Questions and Answers

What is the association of Cryptococcus gattii with regards to environment?

  • Dry desert environments
  • Moist soil
  • Freshwater sources
  • Decaying wood and eucalyptus trees (correct)
  • What is a common characteristic of Cryptococcal meningitis?

  • Rapid onset of symptoms
  • High mortality rate
  • Recurrent episodes
  • Indolent infection (slow onset of symptoms) (correct)
  • What is a possible complication of Cryptococcal meningitis?

  • Cranial nerve palsies and focal brain stem dysfunction (correct)
  • Seizures
  • Gastrointestinal bleeding
  • Pneumonia
  • What is a common manifestation of Cryptococcosis?

    <p>Nodular skin lesions</p> Signup and view all the answers

    What is the typical CSF analysis in Cryptococcal meningitis?

    <p>Color of CSF, White cell counts and cell differentiation</p> Signup and view all the answers

    What is the primary method of diagnosing Cryptococcosis?

    <p>CSF analysis</p> Signup and view all the answers

    What is the main cause of fungal meningitis?

    <p>Cryptococcus neoformans</p> Signup and view all the answers

    What is the characteristic of Cryptococcus neoformans?

    <p>A type of yeast surrounded by a thick coating of capsular polysaccharides</p> Signup and view all the answers

    Who can be affected by Cryptococcal meningitis?

    <p>Patients with depressed cell-mediated immunity, immunocompetent, or with diabetes mellitus</p> Signup and view all the answers

    What is the association of Cryptococcus neoformans with the environment?

    <p>Largely associated with pigeon droppings</p> Signup and view all the answers

    What is the characteristic of C.neoformans var.Grubii and C.neoformans var.neoformans?

    <p>C.neoformans var.Grubii is serotype A and C.neoformans var.neoformans is serotype D</p> Signup and view all the answers

    What is the prevalence of Cryptococcus neoformans in the environment?

    <p>It is ubiquitous worldwide</p> Signup and view all the answers

    What is the recommended treatment for cryptococcal meningitis by the World Health Organization?

    <p>1 mg/kg/day amphotericin B and 100 mg/kg/day flucytosine for one week, followed by fluconazole</p> Signup and view all the answers

    What is the characteristic feature of Zygomycetes?

    <p>Formation of wide, aseptate hyphae</p> Signup and view all the answers

    What is the most common causative organism of rhinocerebral zygomycosis?

    <p>Rhizopus oryzae/arrhizus</p> Signup and view all the answers

    What is the habitat of Zygomycetes?

    <p>Soil, manure and decaying organic matter</p> Signup and view all the answers

    What is the term used to refer to the disease sometimes, due to the characteristic feature of the causative organism?

    <p>Bread mold</p> Signup and view all the answers

    What is the alternative treatment for the initial two weeks of cryptococcal meningitis?

    <p>1200 mg/day fluconazole and 100 mg/kg/day flucytosine</p> Signup and view all the answers

    What is the usual outcome of purely mucocutaneous zygomycosis?

    <p>It is usually not fatal</p> Signup and view all the answers

    What is the purpose of the Calcofluor white stain under fluorescent microscope?

    <p>To observe the apple-green or bluish fluorescence of fungal elements</p> Signup and view all the answers

    What is the typical outcome of CNS histoplasmosis in immunosuppressed individuals?

    <p>Life-threatening injuries with severe clinical manifestations</p> Signup and view all the answers

    What is the characteristic morphology of Histoplasma macroconidia?

    <p>Globose with tuberculate or finger-like cell wall ornamentation</p> Signup and view all the answers

    What is the characteristic feature of the hyphae observed in direct microscopy with KOH wet mount?

    <p>Right-angle branching with a ribbon-like appearance</p> Signup and view all the answers

    What is the primary method of diagnosing CNS histoplasmosis?

    <p>Microscopy and staining of CSF samples</p> Signup and view all the answers

    What is the purpose of the Lactophenol cotton-blue (LCB/LPCB) mount?

    <p>To observe the morphology of fungal elements</p> Signup and view all the answers

    What is the characteristic of the growth of zygomycosis in culture?

    <p>Rapid growth at 25-37C</p> Signup and view all the answers

    What is the typical route of dissemination of Histoplasma to the CNS?

    <p>Via the haematogenous route</p> Signup and view all the answers

    What is the limitation of culturing zygomycosis?

    <p>There is a low culture positivity rate</p> Signup and view all the answers

    What is the characteristic feature of Histoplasma yeasts?

    <p>Small, uniform, narrow-based budding</p> Signup and view all the answers

    What is the purpose of LCB stain in laboratory diagnosis of Histoplasmosis?

    <p>To identify the morphology of Histoplasma macroconidia</p> Signup and view all the answers

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