Podcast
Questions and Answers
Which cells are stimulated by LH to produce testosterone?
Which cells are stimulated by LH to produce testosterone?
- Germ cells
- Sertoli cells
- Spermatogonia
- Leydig cells (correct)
What role does the androgen binding protein (ABP) play in spermatogenesis?
What role does the androgen binding protein (ABP) play in spermatogenesis?
- It stimulates the hypothalamus to release Gn-RH.
- It increases the production of FSH.
- It inhibits the function of Leydig cells.
- It binds to testosterone, making it more soluble and concentrated in Sertoli cells. (correct)
Which hormone is responsible for stimulating differentiation of germ cells?
Which hormone is responsible for stimulating differentiation of germ cells?
- LH
- Testosterone
- FSH (correct)
- Inhibin
What occurs when there is an increase in the level of free testosterone?
What occurs when there is an increase in the level of free testosterone?
Which cells produce the inhibin protein that causes inhibition of FSH secretion?
Which cells produce the inhibin protein that causes inhibition of FSH secretion?
Where are spermatogonia and more differentiated germ cells located?
Where are spermatogonia and more differentiated germ cells located?
What is the main role of Sertoli cells in spermatogenesis?
What is the main role of Sertoli cells in spermatogenesis?
Which cells are found in the interstitial tissue of the testes?
Which cells are found in the interstitial tissue of the testes?
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Study Notes
Functions of Testes
- Produce mature sperms
- Produce hormones, mainly testosterone
Cells Involved in Testicular Functions
- Spermatogonia and differentiated germ cells:
- Present in seminiferous tubules
- Differentiate and mature under the effect of FSH
- Leydig cells:
- Present in interstitial tissue
- Produce testicular hormones, mainly testosterone, under the effect of LH
- Sertoli cells:
- Present at the basement membrane of seminiferous tubules
- Provide media for germ cells differentiation and maturation
- Secrete androgen binding protein (ABP) under the effect of FSH
- ABP makes testosterone more water soluble and concentrated in Sertoli cells
- ABP is responsible for sperm maturation
Spermatogenesis
- Requires Testosterone, ABP, FSH, and LH
Control of Testicular Function
- Hypothalamic-pituitary-testicular axis:
- Regulates testicular function
- Involves production of hypothalamic gonadotropin-releasing hormone (Gn-RH)
- Gn-RH stimulates anterior pituitary to produce FSH and LH
- FSH:
- Stimulates differentiation of germ cells
- Stimulates function of Sertoli cells
- LH:
- Stimulates Leydig cells to produce hormones, mainly testosterone
Negative Feedback Inhibition
- Increase in free testosterone:
- Inhibits LH secretion
- Inhibin:
- Produced by Sertoli cells
- Inhibits FSH secretion
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