Y1S1 006 III Physiology Functions of Haemostasis in the Cardiovascular System

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What is the primary function of haemostasis?

To inhibit the coagulation cascade

To promote excessive bleeding

To prevent blood loss and promote wound healing (correct)

To activate platelets in the absence of injury

What is the primary response of primary haemostasis?

Vasoconstriction (correct)

Formation of a fibrin plug

Activation of inhibitors of haemostasis

Enzymatic activation of coagulation proteins

What is the result of the coagulation cascade in secondary haemostasis?

Formation of a primary platelet plug

Inhibition of platelet activation

Production of fibrin from fibrinogen (correct)

Dissolution of the blood clot

What is the final step in the stages of haemostasis?

Growth of fibrous tissue into the blood clot Signup and view all the answers

What is the primary function of platelets in haemostasis?

To form a temporary platelet plug Signup and view all the answers

What is the result of the inhibition of haemostasis?

Excessive or unwanted bleeding Signup and view all the answers

What is the primary function of prostacyclin in the hemostatic system?

Producing vasodilation and inhibiting platelet aggregation Signup and view all the answers

What is the main receptor involved in platelet adhesion to collagen?

Glycoprotein Ib Signup and view all the answers

Which of the following prostaglandins causes peripheral arteriolar dilation?

PGA1 and PGA2 Signup and view all the answers

What is the result of the interaction between von Willebrand's factor and GPIb platelet receptors?

Platelet activation and recruitment Signup and view all the answers

What is the primary function of thromboxane A2 in the hemostatic system?

Promoting platelet aggregation and causing vasoconstriction Signup and view all the answers

What is the final step in platelet aggregation?

Binding of fibrinogen to GPIIb/IIIa receptors Signup and view all the answers

What is the primary function of the extrinsic pathway in coagulation?

To respond to substances outside of the blood, such as tissue factors Signup and view all the answers

What is the primary role of fibrin-stabilizing factor (Factor XIIIa) in coagulation?

To stabilize the clot Signup and view all the answers

What is the effect of a deficiency in Labile factor (Factor V) on coagulation?

The time required for the clot to form is prolonged Signup and view all the answers

What is the function of the thrombin-activated fibrinolysis inhibitor (TAFI) in coagulation?

To inhibit the fibrinolytic pathway Signup and view all the answers

What is the normal range for the thrombin time?

9-13 seconds Signup and view all the answers

What is the primary function of the intrinsic pathway in coagulation?

To activate the coagulation cascade in response to collagen and other substances in the blood Signup and view all the answers

What percentage of all hemophiliacs have a deficiency of Factor VIII?

80-85% Signup and view all the answers

What is the function of coumarin in therapy?

Prevents thromboembolic events Signup and view all the answers

Which of the following is a tertiary inhibitor of hemostasis?

Thrombin-activated fibrinolytic inhibitor (TAFI) Signup and view all the answers

What is the result of a deficiency in vitamin K dependent coagulation factors?

Prolonged PT Signup and view all the answers

What is the effect of broad-spectrum antibiotics on vitamin K production?

Decreases vitamin K production Signup and view all the answers

Which of the following anticoagulants chelates calcium ions?

EDTA Signup and view all the answers

Which of the following plasma proteins is produced by plasma cells?

Globulin Signup and view all the answers

What is the primary function of alpha, beta, and gamma globulins?

To provide immune system functions Signup and view all the answers

Which of the following is NOT a function of plasma proteins?

Regulation of body temperature Signup and view all the answers

What is the effect of inflammation on the synthesis of plasma proteins?

It increases the synthesis of plasma proteins Signup and view all the answers

What is the term for the liquid portion of blood that remains after clotting and removal of solids?

Serum Signup and view all the answers

Which of the following coagulation factors is NOT produced by the liver?

Gamma globulin Signup and view all the answers