Podcast
Questions and Answers
What type of organisms is Moxifloxacin active against?
What type of organisms is Moxifloxacin active against?
- Anaerobic and gram-positive organisms (correct)
- Viral and parasitic organisms
- Gram-negative and aerobic organisms
- Fungi and protozoa
How do fluoroquinolones enter bacteria?
How do fluoroquinolones enter bacteria?
- Through porin channels (correct)
- Through facilitated diffusion
- Through passive transport
- Through active transport
What is the primary target of fluoroquinolones in bacteria?
What is the primary target of fluoroquinolones in bacteria?
- RNA polymerase
- Peptidoglycan synthesis
- DNA gyrase and topoisomerase IV (correct)
- DNA polymerase
What is another name for DNA gyrase?
What is another name for DNA gyrase?
Which enzyme is not inhibited by fluoroquinolones?
Which enzyme is not inhibited by fluoroquinolones?
What is a common cause of community-acquired pneumonia?
What is a common cause of community-acquired pneumonia?
What is the typical indication for using fluoroquinolones?
What is the typical indication for using fluoroquinolones?
What is the characteristic of moxifloxacin?
What is the characteristic of moxifloxacin?
What is the mechanism of action of fluoroquinolones?
What is the mechanism of action of fluoroquinolones?
What is the advantage of fluoroquinolones over beta-lactam antibiotics?
What is the advantage of fluoroquinolones over beta-lactam antibiotics?
What type of diarrhea is mentioned in the passage?
What type of diarrhea is mentioned in the passage?
What is Ciprofloxacin primarily used for?
What is Ciprofloxacin primarily used for?
Why is Ciprofloxacin used as an alternative?
Why is Ciprofloxacin used as an alternative?
What is the characteristic of fluoroquinolones distribution?
What is the characteristic of fluoroquinolones distribution?
What type of drugs is Ciprofloxacin compared to?
What type of drugs is Ciprofloxacin compared to?
In which tissues are fluoroquinolones levels high?
In which tissues are fluoroquinolones levels high?
Which of the following is an exception in terms of fluoroquinolones levels?
Which of the following is an exception in terms of fluoroquinolones levels?
What type of quinolone is Ciprofloxacin?
What type of quinolone is Ciprofloxacin?
Where do fluoroquinolones concentrations exceed those in serum?
Where do fluoroquinolones concentrations exceed those in serum?
What is true about fluoroquinolones levels in prostatic tissue?
What is true about fluoroquinolones levels in prostatic tissue?
What type of organisms are Legionellaceae and Chlamydiaceae?
What type of organisms are Legionellaceae and Chlamydiaceae?
Which of the following is not typically treated with fluoroquinolones?
Which of the following is not typically treated with fluoroquinolones?
What is the limitation of fluoroquinolones against Neisseria gonorrhoeae?
What is the limitation of fluoroquinolones against Neisseria gonorrhoeae?
What type of bacteria is Mycobacterium tuberculosis?
What type of bacteria is Mycobacterium tuberculosis?
What is the reason fluoroquinolones are not effective against syphilis?
What is the reason fluoroquinolones are not effective against syphilis?
Flashcards are hidden until you start studying
Study Notes
Fluoroquinolones
- Fluoroquinolones are a common cause of CAP (community-acquired pneumonia) and are often used against many types of bacteria.
- Moxifloxacin is a 4th-generation fluoroquinolone, active against anaerobic and gram-positive organisms.
Mechanism of Action
- Fluoroquinolones enter bacteria through porin channels and inhibit DNA gyrase (bacterial topoisomerase II) and bacterial topoisomerase IV.
Antimicrobial Spectrum
- Effective against:
- Atypical organisms: Legionellaceae, Chlamydiaceae
- Gram-positive organisms: Streptococci
- Some mycobacteria: Mycobacterium tuberculosis
- Not effective against:
- Staphylococcus aureus or enterococcal infections
- Syphilis
- Neisseria gonorrhoeae due to widespread resistance
Pharmacokinetics
- Fluoroquinolones have a wide distribution in the body, with high levels in:
- Bone
- Urine (except moxifloxacin)
- Kidney
- Prostatic tissue (but not prostatic fluid)
- Lungs (concentrations exceed those in serum)
Specific Fluoroquinolones
- Ciprofloxacin:
- Most potent against Pseudomonas aeruginosa
- Used as an alternative to more toxic drugs, such as aminoglycosides
- Used to treat traveler's diarrhea
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
