Podcast
Questions and Answers
What is the mechanism of action of fluoroquinolones?
What is the mechanism of action of fluoroquinolones?
- Inhibition of protein synthesis
- Inhibition of cell wall synthesis
- Inhibition of bacterial DNA synthesis by blocking topoisomerase II and IV (correct)
- Activation of beta-lactamase
What type of organisms are fluoroquinolones effective against?
What type of organisms are fluoroquinolones effective against?
- Gram-negative, atypical, gram-positive, and some mycobacteria (correct)
- Only mycobacteria
- Only gram-positive organisms
- Only gram-negative organisms
Why are fluoroquinolones often prescribed?
Why are fluoroquinolones often prescribed?
- For patients with a documented severe allergy to β-lactam antibiotics (correct)
- For patients with a documented allergy to aminoglycosides
- For patients with a severe allergy to macrolides
- For patients with a severe allergy to tetracyclines
What is the effect of inhibition of topoisomerase IV?
What is the effect of inhibition of topoisomerase IV?
What is the effect of inhibition of DNA gyrase?
What is the effect of inhibition of DNA gyrase?
What is the structure of fluoroquinolones?
What is the structure of fluoroquinolones?
What is the reason why levofloxacin and moxifloxacin are referred to as “respiratory fluoroquinolones”?
What is the reason why levofloxacin and moxifloxacin are referred to as “respiratory fluoroquinolones”?
What is the mechanism of resistance to fluoroquinolones?
What is the mechanism of resistance to fluoroquinolones?
What is the effect of divalent and trivalent cations on the oral absorption of fluoroquinolones?
What is the effect of divalent and trivalent cations on the oral absorption of fluoroquinolones?
What is the range of serum half-lives of fluoroquinolones?
What is the range of serum half-lives of fluoroquinolones?
What is the mechanism of elimination of most fluoroquinolones?
What is the mechanism of elimination of most fluoroquinolones?
What is the bioavailability of fluoroquinolones after oral administration?
What is the bioavailability of fluoroquinolones after oral administration?
What is the typical time frame for absorption from an injection site in muscles to reach peak concentrations in blood?
What is the typical time frame for absorption from an injection site in muscles to reach peak concentrations in blood?
What is the normal half-life of aminoglycosides in serum?
What is the normal half-life of aminoglycosides in serum?
What percentage of parenteral aminoglycosides are excreted unchanged in the urine?
What percentage of parenteral aminoglycosides are excreted unchanged in the urine?
What is streptomycin mainly used for in mycobacterial infections?
What is streptomycin mainly used for in mycobacterial infections?
What is the recommended dosage of streptomycin for children in the treatment of mycobacterial infections?
What is the recommended dosage of streptomycin for children in the treatment of mycobacterial infections?
What is gentamicin often used in combination with for the treatment of endocarditis caused by gram-positive bacteria?
What is gentamicin often used in combination with for the treatment of endocarditis caused by gram-positive bacteria?
What is a common use of fluoroquinolones in urinary tract infections (UTIs)?
What is a common use of fluoroquinolones in urinary tract infections (UTIs)?
What is a single dose of 500 mg of fluoroquinolone nearly 100% curative for?
What is a single dose of 500 mg of fluoroquinolone nearly 100% curative for?
What type of bacterial infections are fluoroquinolones used in, especially in soft tissues and joints?
What type of bacterial infections are fluoroquinolones used in, especially in soft tissues and joints?
What is ciprofloxacin used for in regards to anthrax?
What is ciprofloxacin used for in regards to anthrax?
What is a common adverse effect of fluoroquinolones?
What is a common adverse effect of fluoroquinolones?
In what type of infections are fluoroquinolones occasionally used as an alternative?
In what type of infections are fluoroquinolones occasionally used as an alternative?
What is the concentration of gentamicin in creams, ointments, and solutions used for topical application?
What is the concentration of gentamicin in creams, ointments, and solutions used for topical application?
What is the usual route of administration of gentamicin for treating meningitis caused by gram-negative bacteria?
What is the usual route of administration of gentamicin for treating meningitis caused by gram-negative bacteria?
What is the reason behind the nephrotoxicity of gentamicin?
What is the reason behind the nephrotoxicity of gentamicin?
What is the mechanism by which aminoglycosides reduce ACh release from the motor nerve endings?
What is the mechanism by which aminoglycosides reduce ACh release from the motor nerve endings?
What is a common reaction to topically applied neomycin?
What is a common reaction to topically applied neomycin?
