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Questions and Answers
What is the primary action of Fluoroquinolones?
Which of the following is a side effect associated with Fluoroquinolones?
Why are Fluoroquinolones contraindicated in children under 18 years old?
What type of infection can result from the use of Fluoroquinolones?
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Why is it important for patients to take the full course of Fluoroquinolone medication?
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Study Notes
Fluoroquinolones
- Used to treat gram-negative and gram-positive bacterial infections in lower respiratory system, skin and soft tissues, urinary tract, and sexually transmitted diseases
- Effective against inhalation anthrax infections (e.g., levofloxacin)
Medications
- Examples: ciprofloxacin, levofloxacin, ofloxacin
Side Effects
- Central Nervous System (CNS): headache, dizziness, insomnia, depression
- Gastrointestinal (GI): diarrhea, nausea, vomiting
- Hematological: bone marrow depression
- Dermatological: fever, rash, photosensitivity
- Musculoskeletal: tendonitis, tendon rupture (Black Box Warning)
Complications
- Super-infection: C. diff, pseudomembranous colitis (diarrhea), and fungal infections (candidiasis)
Contraindications
- Hypersensitivity reactions
- Children ≤ 18 years (due to risk of tendonitis and tendon rupture)
- Pregnant or lactating women (Pregnancy Category C)
Precautions
- Baseline EKG required to check for prolonged QT interval
- Ensure adequate fluid intake to prevent crystalluria
- Avoid exposure to sunlight
- Patients should take the full course of medication
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Description
Learn about the action and side effects of Fluoroquinolones antibiotics, including their use in treating various bacterial infections and potential adverse reactions. Explore medications like ciprofloxacin, levofloxacin, and ofloxacin, along with common side effects like headache, dizziness, and gastrointestinal issues.
