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Questions and Answers
What is the key difference between the older and newer groups of fluoroquinolones?
What is the key difference between the older and newer groups of fluoroquinolones?
- Different mechanism of action
- Different spectrum of activity (correct)
- Different year of introduction
- Different chemical structure
Why are trovafloxacin and gatifloxacin no longer on the market?
Why are trovafloxacin and gatifloxacin no longer on the market?
- Due to allergic reactions
- Due to liver toxicity and hypoglycemia/hyperglycemia, respectively (correct)
- Due to resistance development
- Due to high cost
Why are the newer fluoroquinolones referred to as respiratory fluoroquinolones?
Why are the newer fluoroquinolones referred to as respiratory fluoroquinolones?
- Due to limited treatment indications
- Due to their activity against S.pneumoniae (correct)
- Due to lack of adverse effects
- Due to specific drug distribution
What is the primary way in which fluoroquinolones exert their bactericidal effects?
What is the primary way in which fluoroquinolones exert their bactericidal effects?
Why is sparfloxacin no longer available in the United States?
Why is sparfloxacin no longer available in the United States?
What distinguishes fluoroquinolones from the older quinolone nalidixic acid in terms of antimicrobial efficacy?
What distinguishes fluoroquinolones from the older quinolone nalidixic acid in terms of antimicrobial efficacy?
What is responsible for the antipseudomonal activity of fluoroquinolones?
What is responsible for the antipseudomonal activity of fluoroquinolones?
Which enzyme do fluoroquinolones inhibit to prevent the relaxation of positively supercoiled DNA?
Which enzyme do fluoroquinolones inhibit to prevent the relaxation of positively supercoiled DNA?
What is the best predictor for clinical efficacy of fluoroquinolones?
What is the best predictor for clinical efficacy of fluoroquinolones?
Which fluoroquinolone has significant activity against anaerobic organisms?
Which fluoroquinolone has significant activity against anaerobic organisms?
What has eroded the utility of fluoroquinolones according to the text?
What has eroded the utility of fluoroquinolones according to the text?
Which enzyme is mutated in organisms that develop resistance to fluoroquinolones?
Which enzyme is mutated in organisms that develop resistance to fluoroquinolones?
Why does the CDC no longer recommend fluoroquinolones for gonorrhea treatment?
Why does the CDC no longer recommend fluoroquinolones for gonorrhea treatment?
What is the main factor associated with clinical failures and resistance development in bacteria?
What is the main factor associated with clinical failures and resistance development in bacteria?
Which population group is at high risk of developing tendon rupture when taking fluoroquinolones?
Which population group is at high risk of developing tendon rupture when taking fluoroquinolones?
What is the primary reason why lactating women should use fluoroquinolones sparingly?
What is the primary reason why lactating women should use fluoroquinolones sparingly?
Which fluoroquinolone is detected in breast milk but ingested in small doses by infants?
Which fluoroquinolone is detected in breast milk but ingested in small doses by infants?
What is the recommended use of fluoroquinolones in patients younger than 18 years according to the FDA?
What is the recommended use of fluoroquinolones in patients younger than 18 years according to the FDA?
Which adverse drug reaction has been reported with nearly all antibacterial agents, including fluoroquinolones?
Which adverse drug reaction has been reported with nearly all antibacterial agents, including fluoroquinolones?
What common GI adverse reactions are associated with fluoroquinolones?
What common GI adverse reactions are associated with fluoroquinolones?
What symptomatology characterizes fluoroquinolone tendinitis?
What symptomatology characterizes fluoroquinolone tendinitis?
What is the main recommendation by the AAP regarding the systemic use of fluoroquinolones in children?
What is the main recommendation by the AAP regarding the systemic use of fluoroquinolones in children?
What health issue has been associated with prolonged or repeated therapy of fluoroquinolones?
What health issue has been associated with prolonged or repeated therapy of fluoroquinolones?
Which fluoroquinolones are known to penetrate the placenta?
Which fluoroquinolones are known to penetrate the placenta?
Which fluoroquinolone is known to have minimal metabolism and predominant renal excretion?
Which fluoroquinolone is known to have minimal metabolism and predominant renal excretion?
What side effect is specifically mentioned as a concern for patients with myasthenia gravis taking fluoroquinolones?
What side effect is specifically mentioned as a concern for patients with myasthenia gravis taking fluoroquinolones?
Why are dosage adjustments necessary for most fluoroquinolones in patients with CrCl of 50 mL/min or less?
Why are dosage adjustments necessary for most fluoroquinolones in patients with CrCl of 50 mL/min or less?
Which warning was published by the FDA regarding fluoroquinolone antibiotic use in 2018?
Which warning was published by the FDA regarding fluoroquinolone antibiotic use in 2018?
What is the predominant route of elimination for nalidixic acid and moxifloxacin?
What is the predominant route of elimination for nalidixic acid and moxifloxacin?
What precautions should patients on fluoroquinolones take to prevent adverse reactions related to photosensitivity?
What precautions should patients on fluoroquinolones take to prevent adverse reactions related to photosensitivity?
What action should patients take if they experience tenderness or inflammation in any tendon while on a fluoroquinolone?
What action should patients take if they experience tenderness or inflammation in any tendon while on a fluoroquinolone?
What is the recommended daily fluid intake to prevent crystalluria while on fluoroquinolones?
What is the recommended daily fluid intake to prevent crystalluria while on fluoroquinolones?
When should diabetic patients report any signs or symptoms of hypoglycemia while on fluoroquinolones?
When should diabetic patients report any signs or symptoms of hypoglycemia while on fluoroquinolones?
What should patients do at any sign of an allergic reaction (hives, itching, dyspnea) while on a fluoroquinolone?
What should patients do at any sign of an allergic reaction (hives, itching, dyspnea) while on a fluoroquinolone?
What is the recommended action for patients experiencing dizziness or lightheadedness while on fluoroquinolones?
What is the recommended action for patients experiencing dizziness or lightheadedness while on fluoroquinolones?
What is a significant implication to consider when selecting fluoroquinolones?
What is a significant implication to consider when selecting fluoroquinolones?
Which fluoroquinolone may be a cost-effective choice due to being on multiple $4 or reduced cost generic lists?
Which fluoroquinolone may be a cost-effective choice due to being on multiple $4 or reduced cost generic lists?
What is a reason to use fluoroquinolones judiciously?
What is a reason to use fluoroquinolones judiciously?
Which fluoroquinolone is unique as an oral agent effective for P. aeruginosa?
Which fluoroquinolone is unique as an oral agent effective for P. aeruginosa?
Which fluoroquinolone achieves a much higher AUC:MIC ratio than levofloxacin and ciprofloxacin?
Which fluoroquinolone achieves a much higher AUC:MIC ratio than levofloxacin and ciprofloxacin?
What should be monitored for patients on prolonged therapy with fluoroquinolones?
What should be monitored for patients on prolonged therapy with fluoroquinolones?
What effect can dehydration lead to in patients taking fluoroquinolones?
What effect can dehydration lead to in patients taking fluoroquinolones?
Why should fluoroquinolones not be taken within 2 to 6 hours of certain drugs?
Why should fluoroquinolones not be taken within 2 to 6 hours of certain drugs?
Which group should avoid using fluoroquinolones unless there are compelling reasons?
Which group should avoid using fluoroquinolones unless there are compelling reasons?
What should patients understand about taking antimicrobial drugs like fluoroquinolones?
What should patients understand about taking antimicrobial drugs like fluoroquinolones?
What is a black box warning associated with the use of fluoroquinolones?
What is a black box warning associated with the use of fluoroquinolones?
Which enzyme is inhibited by ciprofloxacin, leading to increased drug levels of caffeine, zolpidem, and other drugs?
Which enzyme is inhibited by ciprofloxacin, leading to increased drug levels of caffeine, zolpidem, and other drugs?
Why should dairy products not be consumed concurrently with ciprofloxacin?
Why should dairy products not be consumed concurrently with ciprofloxacin?
Which fluoroquinolone is specifically mentioned as increasing cyclosporine's nephrotoxic effects?
Which fluoroquinolone is specifically mentioned as increasing cyclosporine's nephrotoxic effects?
Why are fluoroquinolones no longer recommended as first-line treatment for simple UTIs?
Why are fluoroquinolones no longer recommended as first-line treatment for simple UTIs?
In which condition are fluoroquinolones considered first-line therapy for treatment?
In which condition are fluoroquinolones considered first-line therapy for treatment?
What is the recommended self-treatment for traveler’s diarrhea involving fluoroquinolones?
What is the recommended self-treatment for traveler’s diarrhea involving fluoroquinolones?
Why does the FDA recommend against using fluoroquinolones for acute bacterial sinusitis?
Why does the FDA recommend against using fluoroquinolones for acute bacterial sinusitis?
'Ciprofloxacin should not be used as chemoprophylaxis in pregnant women or children younger than age 18 years' - Why?
'Ciprofloxacin should not be used as chemoprophylaxis in pregnant women or children younger than age 18 years' - Why?
'Ciprofloxacin may be used off-label as a single 500 mg dose as chemoprophylaxis for high-risk adult contacts' - What should be considered before using ciprofloxacin for this purpose?
'Ciprofloxacin may be used off-label as a single 500 mg dose as chemoprophylaxis for high-risk adult contacts' - What should be considered before using ciprofloxacin for this purpose?
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