Fluids and Electrolytes in Clinical Pharmacy
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Questions and Answers

What is the normal range for serum sodium?

  • 125 - 135 mmol/L
  • 115 - 125 mmol/L
  • 145 - 155 mmol/L
  • 135 - 145 mmol/L (correct)
  • In hypovolemic hyponatremia, what are the typical signs and symptoms?

  • Low heart rate and pale skin
  • Excessive thirst and frequent urination
  • Dehydration, dry mucous membrane, poor skin turgor, and orthostatic hypotension (correct)
  • Edema and increased blood pressure
  • What condition may lead to low albumin, resulting in less fluid from interstitial to vascular and causing ascites?

  • Cirrhosis (correct)
  • Diabetes
  • Hypertension
  • Asthma
  • How does the body maintain the normal range of serum sodium?

    <p>With the help of antidiuretic hormone, the RAAS, and atrial natriuretic factor</p> Signup and view all the answers

    What is the main treatment approach for hypovolemic hyponatremia?

    <p>Giving oral rehydration solution (ORS) and NaCl 0.9%</p> Signup and view all the answers

    What percentage of the total body weight accounts for total body water?

    <p>50 - 70%</p> Signup and view all the answers

    Which condition is characterized by elevated serum osmolality and high glucose levels leading to a shift of fluid from cells to extracellular space?

    <p>Hypernatremia</p> Signup and view all the answers

    What treatment is recommended for hypervolemic hyponatremia?

    <p>Na and water restriction, bed rest, manage underlying disease</p> Signup and view all the answers

    What can cause hypernatremia to become hypovolemic?

    <p>Overuse of diuretics or laxatives</p> Signup and view all the answers

    What is the recommended treatment for hypernatremia caused by hypovolemia?

    <p>Replace water deficit with 5% dextrose or 0.45% NaCl</p> Signup and view all the answers

    What condition is characterized by pure water loss from the body with insensible loss that are not replaced with adequate fluids?

    <p>Diabetes Insipidus (DI)</p> Signup and view all the answers

    Which condition may lead to cardiac manifestations like premature ventricular contractions, supraventricular or ventricular tachyarrhythmias, and brady-arrhythmias?

    <p>Hyperkalemia</p> Signup and view all the answers

    What is the recommended treatment for hypercalcemia causing weakness, paralysis, and cardiac conduction abnormalities?

    <p>Antagonizing cardiac effects with calcium (severe), use Na Bicarb</p> Signup and view all the answers

    What is the main cause of hypokalemia?

    <p>Decreased intake of potassium-rich foods</p> Signup and view all the answers

    What are the mechanisms by which the body alters sodium and water excretion and reabsorption to regulate balance?

    <p>The body alters sodium and water excretion and reabsorption to regulate balance through the kidneys, with the help of antidiuretic hormone, the RAAS, and atrial natriuretic factor.</p> Signup and view all the answers

    What are the typical signs and symptoms of hypovolemic hyponatremia?

    <p>The typical signs and symptoms of hypovolemic hyponatremia include dehydration, dry mucous membranes, poor skin turgor, and orthostatic hypotension.</p> Signup and view all the answers

    What condition may lead to low albumin, resulting in less fluid from interstitial to vascular and causing ascites?

    <p>Cirrhosis may lead to low albumin, resulting in less fluid from interstitial to vascular and causing ascites.</p> Signup and view all the answers

    What is the normal range for serum sodium?

    <p>The normal range for serum sodium is 135 – 145 mmol/L.</p> Signup and view all the answers

    What is the percentage of total body water, and what factors does it depend on?

    <p>Total body water accounts for 50 - 70% of the body's weight, and it depends on age, sex, and body muscle to fat ratio.</p> Signup and view all the answers

    What is the treatment for hypovolemic hyponatremia?

    <p>The treatment for hypovolemic hyponatremia includes oral rehydration solution (ORS) and sodium chloride (NaCl) infusion.</p> Signup and view all the answers

    What are the symptoms of hypernatremia above 150 mmol/L?

    <p>thirst, restlessness, irritability, tremulousness</p> Signup and view all the answers

    What treatment is recommended for hypervolemic hyponatremia?

    <p>Na and water restriction, bed rest, and management of underlying disease</p> Signup and view all the answers

    In hypovolemic hypernatremia, what are the typical causes?

    <p>fluid replacement with higher than required Na solution, overuse of diuretics or laxatives</p> Signup and view all the answers

    What are the symptoms of hypokalemia, and what cardiac manifestations may it lead to?

    <p>Symptoms: lethargy, myalgia, cramps, weakness. Cardiac manifestations: premature ventricular contractions, supraventricular or ventricular tachyarrhythmias, brady-arrhythmias, and heart block</p> Signup and view all the answers

    What are the common causes of hyperkalemia?

    <p>increased intake, decreased renal excretion, shift of K from intra- to extra-compartment, drug induced (ACE inhibitors, spironolactone, K supplements)</p> Signup and view all the answers

    What is the recommended treatment for hypokalemia?

    <p>Correct underlying condition, replace K (oral/IV)</p> Signup and view all the answers

    What are the symptoms of hypercalcemia, and what cardiac conduction abnormalities may it cause?

    <p>Symptoms: weakness, paralysis (severe). Cardiac conduction abnormalities: ventricular fibrillation and cardiac arrest</p> Signup and view all the answers

    What is the treatment recommendation for hypercalcemia causing weakness, paralysis, and cardiac conduction abnormalities?

    <p>Antagonizing cardiac effects with calcium (severe), use Na Bicarb</p> Signup and view all the answers

    What are the causes of isovolemic hypernatremia?

    <p>pure water loss from the body with insensible loss that are not replaced with adequate fluids</p> Signup and view all the answers

    What is the primary intracellular cation, and what is the normal range for it?

    <p>Potassium; 3.5 – 5.0 mmol/L</p> Signup and view all the answers

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