Fluid Exchange and Edema Overview
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Questions and Answers

What is the primary location for fluid exchange between plasma and interstitial fluid?

Capillaries

Which of the following are Starling's forces involved in fluid exchange?

  • Interstitial oncotic pressure (correct)
  • Interstitial hydrostatic pressure (correct)
  • Capillary oncotic pressure (correct)
  • Capillary hydrostatic pressure (correct)
  • Capillary hydrostatic pressure favors the absorption of fluid into the capillaries.

    False

    Capillary oncotic pressure (πC) favors the movement of fluid from the interstitium to the capillaries.

    <p>True</p> Signup and view all the answers

    What is the formula for calculating the net filtration pressure (NFP)?

    <p>NFP= HPc - HPISF - TTC + ΠISF</p> Signup and view all the answers

    At the arterial end of the capillary, net filtration pressure is typically positive (greater than zero), making the movement of fluid from the capillaries into the interstitial space dominant.

    <p>True</p> Signup and view all the answers

    At the venular end of the capillary, net filtration pressure is typically negative (less than zero), making the movement of fluid from the interstitial space into the capillaries dominant.

    <p>True</p> Signup and view all the answers

    Approximately what percentage of filtered fluid is reabsorbed back into the capillaries at the venous end?

    <p>90%</p> Signup and view all the answers

    What is the main function of the lymphatic system in regard to fluid exchange?

    <p>The lymphatic system collects excess interstitial fluid and returns it to the bloodstream, preventing fluid buildup.</p> Signup and view all the answers

    What is edema?

    <p>Edema is the abnormal accumulation of fluid in the interstitial space.</p> Signup and view all the answers

    Which of the following factors can contribute to edema?

    <p>Increased permeability of capillaries to proteins</p> Signup and view all the answers

    Which conditions can lead to high capillary hydrostatic pressure?

    <p>Deep vein thrombosis</p> Signup and view all the answers

    Which conditions can lead to low capillary oncotic pressure?

    <p>Chronic renal disease (nephrotic syndrome)</p> Signup and view all the answers

    Which conditions can lead to lymphatic obstruction?

    <p>Filariasis (elephantiasis)</p> Signup and view all the answers

    Which conditions can lead to increased permeability of capillaries to proteins?

    <p>Allergy</p> Signup and view all the answers

    Which of the following are types of edema based on the nature of the fluid accumulation?

    <p>Non-pitting</p> Signup and view all the answers

    Which of the following conditions can lead to pitting edema?

    <p>High capillary hydrostatic pressure</p> Signup and view all the answers

    Which of the following are types of edema based on the distribution of fluid accumulation?

    <p>Generalized</p> Signup and view all the answers

    Which of the following conditions can lead to generalized edema?

    <p>Low capillary oncotic pressure</p> Signup and view all the answers

    Study Notes

    Fluid Exchange and Edema

    • Fluid exchange occurs at capillaries, driven by Starling forces.
    • Starling forces include hydrostatic pressure (water pressure) and oncotic pressure (protein pressure).
    • Hydrostatic pressure pushes fluid out of capillaries into interstitial fluid.
    • Oncotic pressure pulls fluid back into capillaries.
    • At the arterial end of capillaries, hydrostatic pressure is higher than oncotic pressure, resulting in filtration of fluid.
    • At the venous end of capillaries, oncotic pressure is higher than hydrostatic pressure, resulting in absorption of fluid.
    • The remaining 10% of filtered fluid is absorbed by lymphatic vessels.
    • Edema is abnormal fluid collection in the interstitial fluid, with pitting and non-pitting types.

    Mechanisms of Edema

    • High hydrostatic pressure (HPc) can cause edema; this is caused by heart failure or venous obstruction.
    • Low oncotic pressure (OPc) can cause edema; this is caused by malnutrition, malabsorption, Chronic liver disease or Chronic renal disease (nephrotic syndrome).
    • Lymphatic obstruction, tumors or surgical removal can also lead to edema.
    • Allergy, inflammation or burns can also lead to increased edema through increased capillary permeability.

    Types of Edema

    • Edema can be classified as pitting or non-pitting.
    • Pitting edema is caused by high hydrostatic pressure and low oncotic pressure, and affects multiple areas of the body (generalized).
    • Non-pitting edema is caused by lymphatic obstruction, increased capillary permeability or localized causes, and is often localized.
    • Generalized edema can result from low capillary oncotic pressure, such as Congestive Heart Failure.
    • Localized edema is often associated with lymphatic obstruction, venous obstruction or causes of increased permeability.

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    Description

    This quiz covers the essentials of fluid exchange at capillaries, focusing on Starling forces, hydrostatic pressure, and oncotic pressure. It also explores the mechanisms of edema, its causes, and types. Understanding these concepts is vital for grasping how fluid dynamics affect health.

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