Flockhart Table and P450 Drug Interactions
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Questions and Answers

Which of the following substances is known to interact with multiple medications according to the Flockhart Table?

  • Omeprazole
  • Troglitazone
  • St. John's Wort (correct)
  • Phenobarbital

    • Which medication is indicated to interact with oxcarbazepine according to the content?

  • Phenytoin (correct)
  • Pioglitazone
  • Tobacco
  • Rifabutin

    • Which of the following is not listed as having an interaction with the medications mentioned?

  • Citalopram (correct)
  • Omeprazole
  • Rifampin
  • St. John's Wort

    • Which substance is commonly associated with inducing liver enzymes and is known for its interactions?

    <p>Rifampin</p> Signup and view all the answers

    Which of the following medications is noted for having several drug-drug interactions?

    <p>Phenobarbital</p> Signup and view all the answers

    Which medication is a substrate of CYP1A2?

    <p>Ondansetron</p> Signup and view all the answers

    Which of the following medications is NOT a substrate of CYP2D6?

    <p>Hydrocodone</p> Signup and view all the answers

    Which drug is identified as a substrate of CYP3A4?

    <p>Aprepitant</p> Signup and view all the answers

    Which of the following is TRUE about atorvastatin?

    <p>It is an inhibitor of HMG CoA reductase.</p> Signup and view all the answers

    What is the role of inhibitors in drug metabolism?

    <p>They compete with substrates for enzyme binding.</p> Signup and view all the answers

    Which of the following medications does NOT inhibit HMG CoA reductase?

    <p>Risperidone</p> Signup and view all the answers

    Which of these drugs is a CYP2C9 substrate?

    <p>Nortriptyline</p> Signup and view all the answers

    Which of the following defines a strong inhibitor?

    <p>Causes a &gt; 5-fold increase in plasma AUC values.</p> Signup and view all the answers

    What constitutes a moderate inhibitor?

    <p>An increase in plasma AUC by more than 2-fold.</p> Signup and view all the answers

    Which drug is commonly known for its interactions with CYP2C19?

    <p>Nisoldipine</p> Signup and view all the answers

    Which medication is NOT a substrate of CYP2B6?

    <p>Cilostazol</p> Signup and view all the answers

    Which of these drugs is NOT listed as a substrate?

    <p>aspirin</p> Signup and view all the answers

    Which of the following is a known CYP3A4 substrate?

    <p>Ondansetron</p> Signup and view all the answers

    Which of the following describes a weak inhibitor?

    <p>An increase in plasma AUC of 1.5-fold.</p> Signup and view all the answers

    Which medication is an example of a CYP2C8 substrate?

    <p>Perhexiline</p> Signup and view all the answers

    What can be a consequence of using a strong inhibitor with a substrate?

    <p>The response to the medication may become ineffective.</p> Signup and view all the answers

    What is the expected plasma AUC increase for a moderate inhibitor?

    <p>More than 2-fold.</p> Signup and view all the answers

    Which enzyme is mentioned as part of the substrate-related information?

    <p>2B6</p> Signup and view all the answers

    Which drug is known to induce the enzyme CYP2B6?

    <p>Phenobarbital</p> Signup and view all the answers

    Which of the following substances acts as an inducer for multiple cytochrome P450 enzymes?

    <p>St. John's Wort</p> Signup and view all the answers

    What is the role of inducers in drug metabolism?

    <p>They enhance enzyme activity.</p> Signup and view all the answers

    Which food item is listed as an inducer for the enzyme CYP1A2?

    <p>Broccoli</p> Signup and view all the answers

    Which drug is NOT an inducer of CYP2C9?

    <p>Phenobarbital</p> Signup and view all the answers

    Which of the following is associated with the induction of CYP3A4?

    <p>Barbiturates</p> Signup and view all the answers

    Which drug is known to be a substrate of the 2D6 enzyme?

    <p>Propranolol</p> Signup and view all the answers

    What is a common characteristic of drugs like efavirenz and nevirapine?

    <p>They are known inducers.</p> Signup and view all the answers

    Which medication is a substrate of the 3A4 enzyme?

    <p>Dexamethasone</p> Signup and view all the answers

    What is a common substrate of the 2C9 enzyme?

    <p>Finasteride</p> Signup and view all the answers

    Which of the following medications is listed as an inducer of CYP2D6?

    <p>Dexamethasone</p> Signup and view all the answers

    Which drug is associated with the 2B6 enzyme?

    <p>Domperidone</p> Signup and view all the answers

    Which of the following drugs is not metabolized by the 2E1 enzyme?

    <p>Romidepsin</p> Signup and view all the answers

    Identify a substrate for the 2C19 enzyme from the options below.

    <p>Tamoxifen</p> Signup and view all the answers

    Which drug is a well-known substrate of the 2C8 enzyme?

    <p>Nateglinide</p> Signup and view all the answers

    Which of the following drugs is metabolized by the 3A4, 5, or 7 enzymes?

    <p>Nevirapine</p> Signup and view all the answers

    Which medication has no relationship with the 2D6 enzyme?

    <p>Eplerenone</p> Signup and view all the answers

    Which of these drugs is NOT a substrate of the 2C9 enzyme?

    <p>Romidepsin</p> Signup and view all the answers

    Which of the following drugs is a substrate for P450 2D6?

    <p>Tamoxifen</p> Signup and view all the answers

    Which type of drug increases the enzyme's ability to metabolize substrates?

    <p>Activators</p> Signup and view all the answers

    Which of the following is NOT a substrate for P450 1A2?

    <p>Propranolol</p> Signup and view all the answers

    What can prescribers anticipate by knowing the dominant cytochrome P450 isoform of a drug?

    <p>Possible metabolic interactions with other drugs.</p> Signup and view all the answers

    Which of the following statements about substrates is true?

    <p>They are metabolized by enzymes.</p> Signup and view all the answers

    Which drug class is a known inhibitor of P450 2C19?

    <p>Proton Pump Inhibitors</p> Signup and view all the answers

    Which substrate is associated with the drug class of anti-epileptics?

    <p>Phenytoin</p> Signup and view all the answers

    What is a common characteristic of substrates in the context of drug interactions?

    <p>They are metabolized by the enzyme.</p> Signup and view all the answers

    Which drug is shown to be a substrate for cytochrome P450 3A4?

    <p>Ketamine</p> Signup and view all the answers

    What is the main function of drug activators in metabolism?

    <p>They increase the enzyme's metabolic capabilities.</p> Signup and view all the answers

    Which P450 isoform is involved in metabolizing antidepressants such as fluoxetine?

    <p>2D6</p> Signup and view all the answers

    Which of the following drugs would be considered an inhibitor for cytochrome P450 2C8?

    <p>Amodiaquine</p> Signup and view all the answers

    Which drug is explicitly listed as a substrate for the P450 1A2 isoform?

    <p>Caffeine</p> Signup and view all the answers

    What would be the likely outcome if a drug that inhibits P450 2C9 is taken alongside a 2C9 substrate?

    <p>Reduced metabolism of the substrate drug.</p> Signup and view all the answers

    Study Notes

    Flockhart Table

    • The Flockhart Table is a tool for understanding drug interactions.
    • It's helpful in clinical prescribing when knowing how drugs are metabolized is crucial.
    • The table categorizes drugs by their cytochrome P450 isoform.
    • A drug can function as a substrate (metabolized by the enzyme), inhibitor (prevents enzyme activity), or activator (increases enzyme activity).
    • Recognizing these roles helps predict potential interactions between medications.

    P450 Drug Interaction Table

    • This table details various drug interactions based on the particular cytochrome P450 enzyme (e.g., 1A2, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, 3A4,5,7).

    • The table shows which drugs act as substrates, inhibitors, or activators for particular enzymes.

    • This information helps anticipate potential drug interactions based on how each medication metabolizes.

    • The table contains specific examples of drugs grouped by the enzyme they affect.

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    Related Documents

    Flockhart Table Medication Metabolism PDF

    Description

    This quiz covers the Flockhart Table and the P450 drug interaction principles essential for clinical prescribing. It details how drugs interact through cytochrome P450 isoforms, identifying drug roles as substrates, inhibitors, or activators. Understanding these interactions is critical for anticipating medication effects.

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