Fetal Development Overview
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Which of the following is the correct definition of the fetal period?

  • From the 9th week to birth (correct)
  • The first 2 weeks after fertilization
  • The period from implantation to birth
  • From the 3rd week to the 8th week of gestation
  • Which term refers to the positioning of the fetus with the head down in the uterus?

  • Transverse presentation
  • Breech presentation
  • Cephalic presentation (correct)
  • Longitudinal presentation
  • The first trimester of pregnancy spans which weeks?

  • Weeks 1 to 8
  • Weeks 1 to 12 (correct)
  • Weeks 13 to 24
  • Weeks 25 to 40
  • Which part of the male reproductive system is responsible for the production of sperm?

    <p>Testes</p> Signup and view all the answers

    What is the primary purpose of meiosis in human reproduction?

    <p>To reduce the chromosome number by half for gamete formation</p> Signup and view all the answers

    Which of the following is NOT a phase of meiosis?

    <p>Interphase</p> Signup and view all the answers

    During which phase of meiosis does crossing-over occur?

    <p>Prophase I</p> Signup and view all the answers

    At what stage of meiosis does a secondary oocyte arrest until fertilization?

    <p>Metaphase II</p> Signup and view all the answers

    How many chromosomes does each gamete (sperm or oocyte) contain after meiosis?

    <p>23 chromosomes</p> Signup and view all the answers

    The first step of fertilization is:

    <p>The sperm undergoes the acrosomal reaction</p> Signup and view all the answers

    In response to fertilization, which of the following occurs in the uterus?

    <p>The uterine mucosa thickens</p> Signup and view all the answers

    Which structure forms during the second week of embryonic development?

    <p>Amniotic cavity</p> Signup and view all the answers

    The syncytiotrophoblast is responsible for:

    <p>Secretion of human chorionic gonadotropin (hCG)</p> Signup and view all the answers

    Gastrulation leads to the formation of which primary germ layers?

    <p>Ectoderm, Mesoderm, Endoderm</p> Signup and view all the answers

    Neurulation refers to the formation of which structure?

    <p>Neural tube</p> Signup and view all the answers

    During which week does the primitive heart begin to beat in an embryo?

    <p>Week 3</p> Signup and view all the answers

    The fetal period begins in which week of pregnancy?

    <p>Week 9</p> Signup and view all the answers

    During the second trimester, which of the following occurs?

    <p>Rapid weight gain and fat deposition</p> Signup and view all the answers

    Which of the following is NOT a fetal membrane?

    <p>Placenta</p> Signup and view all the answers

    The placental barrier is made up of which of the following layers?

    <p>Syncytiotrophoblast and cytotrophoblast</p> Signup and view all the answers

    Which of the following is a known teratogen associated with the development of cleft palate?

    <p>Alcohol</p> Signup and view all the answers

    Genetic mutations in which gene are commonly associated with neural tube defects?

    <p>Sonic hedgehog (SHH)</p> Signup and view all the answers

    Which of the following diagnostic tests involves the sampling of cells from the placenta for genetic analysis?

    <p>Chorionic villus sampling</p> Signup and view all the answers

    Which of the following is the primary purpose of an ultrasound during pregnancy?

    <p>To assess fetal size and development</p> Signup and view all the answers

    A 30-year-old woman is 12 weeks pregnant and presents for her first prenatal visit. She mentions that her previous pregnancy ended in miscarriage during the first trimester. She requests genetic testing. What is the most appropriate diagnostic method for detecting chromosomal abnormalities at this stage?

    <p>Chorionic villus sampling</p> Signup and view all the answers

    A 35-year-old woman is in her second trimester and undergoes an ultrasound, revealing a neural tube defect. Which of the following genetic abnormalities is most commonly associated with neural tube defects?

    <p>Folate deficiency</p> Signup and view all the answers

    During the embryonic period, the development of which of the following structures is most sensitive to teratogens?

    <p>Heart</p> Signup and view all the answers

    At which stage of development is the embryo referred to as a blastocyst?

    <p>At implantation</p> Signup and view all the answers

    The Leydig cells in the testes produce which of the following hormones during fetal development?

    <p>Testosterone</p> Signup and view all the answers

    Which of the following statements is true about the difference between mitosis and meiosis?

    <p>Mitosis results in two genetically identical cells, while meiosis results in four genetically different cells.</p> Signup and view all the answers

    What is the significance of anaphase I in meiosis?

    <p>Homologous chromosomes are separated</p> Signup and view all the answers

    What is the result of spermatogenesis in terms of the number of functional gametes produced?

    <p>Four functional sperm</p> Signup and view all the answers

    The primary oocyte in females arrests at which stage of meiosis before puberty?

    <p>Prophase I</p> Signup and view all the answers

    The acrosomal reaction during fertilization allows the sperm to:

    <p>Penetrate the zona pellucida</p> Signup and view all the answers

    Following fertilization, the zygote undergoes cleavage. What is the outcome of this process?

    <p>Formation of a blastocyst</p> Signup and view all the answers

    The bilaminar disc consists of which two layers?

    <p>Epiblast and hypoblast</p> Signup and view all the answers

    The trophoblast differentiates into which two layers during the second week of development?

    <p>Inner cytotrophoblast and outer syncytiotrophoblast</p> Signup and view all the answers

    In gastrulation, the primitive streak is important for the formation of which of the following?

    <p>Mesoderm</p> Signup and view all the answers

    The notochord, which plays a key role in inducing neural development, is derived from which germ layer?

    <p>Mesoderm</p> Signup and view all the answers

    By the end of the fourth week of development, the embryonic heart:

    <p>Begins beating</p> Signup and view all the answers

    During the fourth week of embryonic development, the somites are responsible for the development of:

    <p>Vertebrae and skeletal muscles</p> Signup and view all the answers

    In the fetal period, the brain undergoes significant development, which begins at which point?

    <p>Week 9</p> Signup and view all the answers

    The amniotic fluid is produced primarily by:

    <p>Fetal kidneys</p> Signup and view all the answers

    The chorionic villi are important in:

    <p>Forming the placenta</p> Signup and view all the answers

    A pregnant woman is exposed to high doses of radiation during her first trimester. Which of the following malformations is most likely to occur?

    <p>Neural tube defects</p> Signup and view all the answers

    A mutation in the FGF8 gene can result in which of the following congenital malformations?

    <p>Limb malformations</p> Signup and view all the answers

    Amniocentesis is typically performed during which week of pregnancy?

    <p>Week 15-20</p> Signup and view all the answers

    Which of the following antenatal diagnostic techniques is non-invasive and used to detect fetal abnormalities by analyzing fetal DNA in maternal blood?

    <p>Non-invasive prenatal testing (NIPT)</p> Signup and view all the answers

    A 25-year-old woman presents to the clinic for her first prenatal visit at 18 weeks of gestation. She requests genetic testing for Down syndrome. What is the most appropriate non-invasive screening test for her at this stage?

    <p>Ultrasound and serum screening</p> Signup and view all the answers

    A 34-year-old woman who is 10 weeks pregnant presents with concerns about her risk for having a child with a genetic disorder. She has a family history of cystic fibrosis. Which antenatal diagnostic technique would be most appropriate for assessing this risk?

    <p>Carrier screening for cystic fibrosis</p> Signup and view all the answers

    Which of the following is a key characteristic of the fetal period?

    <p>Growth and maturation of organs</p> Signup and view all the answers

    The transition from the embryonic to fetal period occurs at:

    <p>8 weeks</p> Signup and view all the answers

    Which of the following is the main difference between anaphase of mitosis and anaphase I of meiosis?

    <p>In mitosis, sister chromatids are separated, while in meiosis I, homologous chromosomes are separated.</p> Signup and view all the answers

    Which of the following phases in meiosis is characterized by crossing-over between homologous chromosomes?

    <p>Prophase I</p> Signup and view all the answers

    During oogenesis, the secondary oocyte is arrested in which stage of meiosis before fertilization?

    <p>Metaphase II</p> Signup and view all the answers

    Spermatogenesis results in the production of how many functional sperm cells from one primary spermatocyte?

    <p>Four</p> Signup and view all the answers

    During implantation, the blastocyst attaches to the endometrial lining through which layer?

    <p>Syncytiotrophoblast</p> Signup and view all the answers

    The extra-embryonic mesoderm contributes to the formation of which structure during the second week?

    <p>Placenta</p> Signup and view all the answers

    . Which of the following structures forms from the epiblast during the second week of development?

    <p>Amniotic cavity</p> Signup and view all the answers

    Study Notes

    Fetal Development

    • Fetal Period: The period from the 9th week of gestation to birth.
    • First Trimester: Weeks 1-12 of pregnancy.
    • Cephalic Presentation: The fetus' head is positioned down in the uterus.
    • Mesonephric Ducts (Males): Develop into the vas deferens.
    • Mullerian Ducts (Females): Develop into the uterus.
    • Sperm Production: Occurs in the testes.
    • Meiosis: The process of cell division that produces gametes (sperm or egg).
    • Meiosis I Phases: Prophase I (crossing-over occurs), Metaphase I, Anaphase I (homologous chromosomes separate), and Telophase I.
    • Meiosis II Phases: Prophase II, Metaphase II, Anaphase II (sister chromatids separate), Telophase II.
    • Gamete Chromosome Number: 23 chromosomes.
    • Fertilization Steps: Sperm penetrates the egg's cytoplasm; the sperm undergoes the acrosomal reaction; the fertilized egg begins mitosis, and the zygote implants in the uterine lining.
    • Uterine Changes: The uterine mucosa thickens in response to fertilization.
    • Embryonic Development Structure: Amniotic cavity forms in the second week of embryonic development.
    • Germ Layers: Ectoderm, Mesoderm, Endoderm.
    • Neural Tube Formation: Occurs during neurulation.
    • Heart Beat: Begins around week 3.
    • Limb Formation: First sign occurs during week 4.
    • Second Trimester Characteristics: Rapid weight gain, and fat deposition; development of heart chambers.
    • Fetal Membranes (Not a Fetal Membrane): Placenta.
    • Fetal Membranes: Amnion, Chorion, Allantois.
    • Placental Barrier: Syncytiotrophoblast and cytotrophoblast.
    • Teratogens: Substances that can cause birth defects, such as alcohol, thalidomide, and retinoic acid.
    • Fetal Period Organ System: Respiratory system.
    • Amniotic Fluid Production: Primarily by fetal kidneys.
    • Embryonic Periods: The development of the brain and initial stages of organs.
    • Chorionic Villi: Important for nutrient exchange, and producing hCG.
    • Prenatal Testing:
      • Ultrasound: Used to assess fetal development and size, fetal structure.
      • Chorionic Villus Sampling (CVS): Done during 12-14 weeks for genetic abnormalities.
      • Amniocentesis: Done in the 15-20 weeks for genetic disorders.
      • Non-invasive Prenatal Testing (NIPT): Analyzes fetal DNA in maternal blood for genetic analysis.
      • Carrier Screening: Identifies if a parent carries a genetic trait that could affect the baby.
    • Genetic Disorders: Conditions caused by genetic mutations, such as Neural Tube Defects, Down Syndrome, Spina Bifida, Cleft Lip and Palate, Cystic Fibrosis et al..
    • Maternal Age and Genetic Conditions: Down syndrome is often associated with older mothers.
    • Abnormal Placenta Location: Low-lying placenta in the 20 weeks of pregnancy. This may result in early-term labor.
    • Fetal Length at 3rd Trimester End: Approximately 50 cm.
    • Structure Responsible for Nutrient/Waste Exchange: Placenta.
    • Amniotic Fluid Function: Cushions the fetus; helps maintain a constant temperature, assists in lung development.
    • First Event after Fertilization: Activation of egg metabolism.
    • Attachment Site in Implantation: Syncytiotrophoblast.
    • Umbilical Cord Composition: One artery and two veins.
    • Teratogen Associated with Limb Defects: Thalidomide.
    • Teratogen Associated with Cleft Palate: Retinoic acid

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