Fetal Development Overview
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Questions and Answers

Which of the following is the correct definition of the fetal period?

  • From the 9th week to birth (correct)
  • The first 2 weeks after fertilization
  • The period from implantation to birth
  • From the 3rd week to the 8th week of gestation

Which term refers to the positioning of the fetus with the head down in the uterus?

  • Transverse presentation
  • Breech presentation
  • Cephalic presentation (correct)
  • Longitudinal presentation

The first trimester of pregnancy spans which weeks?

  • Weeks 1 to 8
  • Weeks 1 to 12 (correct)
  • Weeks 13 to 24
  • Weeks 25 to 40

Which part of the male reproductive system is responsible for the production of sperm?

<p>Testes (B)</p> Signup and view all the answers

What is the primary purpose of meiosis in human reproduction?

<p>To reduce the chromosome number by half for gamete formation (C)</p> Signup and view all the answers

Which of the following is NOT a phase of meiosis?

<p>Interphase (C)</p> Signup and view all the answers

During which phase of meiosis does crossing-over occur?

<p>Prophase I (A)</p> Signup and view all the answers

At what stage of meiosis does a secondary oocyte arrest until fertilization?

<p>Metaphase II (A)</p> Signup and view all the answers

How many chromosomes does each gamete (sperm or oocyte) contain after meiosis?

<p>23 chromosomes (D)</p> Signup and view all the answers

The first step of fertilization is:

<p>The sperm undergoes the acrosomal reaction (D)</p> Signup and view all the answers

In response to fertilization, which of the following occurs in the uterus?

<p>The uterine mucosa thickens (A)</p> Signup and view all the answers

Which structure forms during the second week of embryonic development?

<p>Amniotic cavity (A)</p> Signup and view all the answers

The syncytiotrophoblast is responsible for:

<p>Secretion of human chorionic gonadotropin (hCG) (B)</p> Signup and view all the answers

Gastrulation leads to the formation of which primary germ layers?

<p>Ectoderm, Mesoderm, Endoderm (B)</p> Signup and view all the answers

Neurulation refers to the formation of which structure?

<p>Neural tube (D)</p> Signup and view all the answers

During which week does the primitive heart begin to beat in an embryo?

<p>Week 3 (D)</p> Signup and view all the answers

The fetal period begins in which week of pregnancy?

<p>Week 9 (A)</p> Signup and view all the answers

During the second trimester, which of the following occurs?

<p>Rapid weight gain and fat deposition (C)</p> Signup and view all the answers

Which of the following is NOT a fetal membrane?

<p>Placenta (B)</p> Signup and view all the answers

The placental barrier is made up of which of the following layers?

<p>Syncytiotrophoblast and cytotrophoblast (C)</p> Signup and view all the answers

Which of the following is a known teratogen associated with the development of cleft palate?

<p>Alcohol (D)</p> Signup and view all the answers

Genetic mutations in which gene are commonly associated with neural tube defects?

<p>Sonic hedgehog (SHH) (C)</p> Signup and view all the answers

Which of the following diagnostic tests involves the sampling of cells from the placenta for genetic analysis?

<p>Chorionic villus sampling (B)</p> Signup and view all the answers

Which of the following is the primary purpose of an ultrasound during pregnancy?

<p>To assess fetal size and development (C)</p> Signup and view all the answers

A 30-year-old woman is 12 weeks pregnant and presents for her first prenatal visit. She mentions that her previous pregnancy ended in miscarriage during the first trimester. She requests genetic testing. What is the most appropriate diagnostic method for detecting chromosomal abnormalities at this stage?

<p>Chorionic villus sampling (A)</p> Signup and view all the answers

A 35-year-old woman is in her second trimester and undergoes an ultrasound, revealing a neural tube defect. Which of the following genetic abnormalities is most commonly associated with neural tube defects?

<p>Folate deficiency (B)</p> Signup and view all the answers

During the embryonic period, the development of which of the following structures is most sensitive to teratogens?

<p>Heart (A)</p> Signup and view all the answers

At which stage of development is the embryo referred to as a blastocyst?

<p>At implantation (D)</p> Signup and view all the answers

The Leydig cells in the testes produce which of the following hormones during fetal development?

<p>Testosterone (B)</p> Signup and view all the answers

Which of the following statements is true about the difference between mitosis and meiosis?

<p>Mitosis results in two genetically identical cells, while meiosis results in four genetically different cells. (B)</p> Signup and view all the answers

What is the significance of anaphase I in meiosis?

<p>Homologous chromosomes are separated (D)</p> Signup and view all the answers

What is the result of spermatogenesis in terms of the number of functional gametes produced?

<p>Four functional sperm (B)</p> Signup and view all the answers

The primary oocyte in females arrests at which stage of meiosis before puberty?

<p>Prophase I (D)</p> Signup and view all the answers

The acrosomal reaction during fertilization allows the sperm to:

<p>Penetrate the zona pellucida (C)</p> Signup and view all the answers

Following fertilization, the zygote undergoes cleavage. What is the outcome of this process?

<p>Formation of a blastocyst (D)</p> Signup and view all the answers

The bilaminar disc consists of which two layers?

<p>Epiblast and hypoblast (A)</p> Signup and view all the answers

The trophoblast differentiates into which two layers during the second week of development?

<p>Inner cytotrophoblast and outer syncytiotrophoblast (A)</p> Signup and view all the answers

In gastrulation, the primitive streak is important for the formation of which of the following?

<p>Mesoderm (A)</p> Signup and view all the answers

The notochord, which plays a key role in inducing neural development, is derived from which germ layer?

<p>Mesoderm (B)</p> Signup and view all the answers

By the end of the fourth week of development, the embryonic heart:

<p>Begins beating (B)</p> Signup and view all the answers

During the fourth week of embryonic development, the somites are responsible for the development of:

<p>Vertebrae and skeletal muscles (A)</p> Signup and view all the answers

In the fetal period, the brain undergoes significant development, which begins at which point?

<p>Week 9 (B)</p> Signup and view all the answers

The amniotic fluid is produced primarily by:

<p>Fetal kidneys (D)</p> Signup and view all the answers

The chorionic villi are important in:

<p>Forming the placenta (A)</p> Signup and view all the answers

A pregnant woman is exposed to high doses of radiation during her first trimester. Which of the following malformations is most likely to occur?

<p>Neural tube defects (B)</p> Signup and view all the answers

A mutation in the FGF8 gene can result in which of the following congenital malformations?

<p>Limb malformations (A)</p> Signup and view all the answers

Amniocentesis is typically performed during which week of pregnancy?

<p>Week 15-20 (C)</p> Signup and view all the answers

Which of the following antenatal diagnostic techniques is non-invasive and used to detect fetal abnormalities by analyzing fetal DNA in maternal blood?

<p>Non-invasive prenatal testing (NIPT) (C)</p> Signup and view all the answers

A 25-year-old woman presents to the clinic for her first prenatal visit at 18 weeks of gestation. She requests genetic testing for Down syndrome. What is the most appropriate non-invasive screening test for her at this stage?

<p>Ultrasound and serum screening (A)</p> Signup and view all the answers

A 34-year-old woman who is 10 weeks pregnant presents with concerns about her risk for having a child with a genetic disorder. She has a family history of cystic fibrosis. Which antenatal diagnostic technique would be most appropriate for assessing this risk?

<p>Carrier screening for cystic fibrosis (B)</p> Signup and view all the answers

Which of the following is a key characteristic of the fetal period?

<p>Growth and maturation of organs (A)</p> Signup and view all the answers

The transition from the embryonic to fetal period occurs at:

<p>8 weeks (B)</p> Signup and view all the answers

Which of the following is the main difference between anaphase of mitosis and anaphase I of meiosis?

<p>In mitosis, sister chromatids are separated, while in meiosis I, homologous chromosomes are separated. (A)</p> Signup and view all the answers

Which of the following phases in meiosis is characterized by crossing-over between homologous chromosomes?

<p>Prophase I (C)</p> Signup and view all the answers

During oogenesis, the secondary oocyte is arrested in which stage of meiosis before fertilization?

<p>Metaphase II (D)</p> Signup and view all the answers

Spermatogenesis results in the production of how many functional sperm cells from one primary spermatocyte?

<p>Four (D)</p> Signup and view all the answers

During implantation, the blastocyst attaches to the endometrial lining through which layer?

<p>Syncytiotrophoblast (C)</p> Signup and view all the answers

The extra-embryonic mesoderm contributes to the formation of which structure during the second week?

<p>Placenta (B)</p> Signup and view all the answers

. Which of the following structures forms from the epiblast during the second week of development?

<p>Amniotic cavity (A)</p> Signup and view all the answers

Flashcards

Fetal Period

The period from the 9th week of gestation to birth, characterized by rapid growth and maturation of organs.

Cephalic Presentation

The positioning of the fetus with its head down in the uterus, signifying the ideal position for vaginal delivery.

First Trimester

The first 12 weeks of pregnancy, encompassing the embryonic period and the early stages of fetal development.

Mesonephric Duct (Males)

A duct that, in males, develops into the vas deferens, a critical component of the male reproductive system responsible for carrying sperm.

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Mullerian Duct (Females)

A duct that, in females, develops into the uterus, a vital organ for fetal development and gestation.

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Testes

The primary reproductive organ in males, responsible for producing sperm and testosterone - the male sex hormone.

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Meiosis

This process, critical for sexual reproduction, reduces the chromosome number in gametes by half, ensuring offspring inherit half of their genetic material from each parent.

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Prophase I (Meiosis)

The phase of meiosis where crossing-over occurs, resulting in exchange of genetic material between homologous chromosomes.

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Metaphase II (Meiosis)

A secondary oocyte is arrested at this stage of meiosis until fertilization occurs, allowing for potential fertilization.

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Chromosome Number in Gametes

Each gamete (sperm or egg) contains 23 chromosomes, representing half the number found in somatic cells.

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Acrosomal Reaction

The initial step of fertilization, involving the sperm's enzymatic breakdown of the egg's outer layer, the zona pellucida, allowing it to penetrate.

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Uterine Mucosa Thickening

The thickening of the uterine lining in response to fertilization, creating a suitable environment for implantation and fetal development.

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Amniotic Cavity

The fluid-filled sac that surrounds the developing embryo, offering protection and cushioning.

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Syncytiotrophoblast

A layer of the blastocyst that produces human chorionic gonadotropin (hCG), a hormone essential for maintaining pregnancy in the early stages.

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Gastrulation

This process, taking place during the third week of development, forms the three primary germ layers: ectoderm, mesoderm, and endoderm, setting the stage for organ development.

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Neurulation

The development of the nervous system, involving the formation of the neural tube, which gives rise to the brain and spinal cord.

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Week 3 of Embryonic Development

The embryonic heart begins beating at this point, marking a crucial milestone in the development of the circulatory system.

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Week 4 of Embryonic Development

The initial sign of limb formation, appearing as limb buds, occurs during this week.

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Fetal Membranes

The fetal membranes form a protective barrier around the embryo, providing cushioning and support.

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Placental Barrier

The placental barrier, made up of the syncytiotrophoblast and cytotrophoblast, separates maternal and fetal blood, facilitating nutrient exchange.

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Teratogen

A harmful agent that can cause birth defects, such as alcohol, which is linked to cleft palate.

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Sonic Hedgehog (SHH) Gene

This gene mutation is commonly linked to neural tube defects, highlighting the importance of proper prenatal care.

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Chorionic Villus Sampling

This diagnostic test involves collecting cells from the placenta for genetic analysis, allowing for early detection of chromosomal abnormalities.

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Non-invasive Prenatal Testing (NIPT)

A non-invasive prenatal test that analyzes fetal DNA from maternal blood, aiding in the detection of chromosomal abnormalities.

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Ultrasound

This diagnostic technique uses sound waves to create images of the developing fetus, allowing for assessment of growth and development.

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Fetal Period

The stage of development characterized by rapid growth and maturation of organ systems, building upon the foundation laid during the embryonic period.

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Transition from Embryonic to Fetal Period

The process during which the embryonic period transitions into the fetal period, occurring by the 8th week of gestation.

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Mullerian Ducts (Females)

These ducts, in females, develop into the uterus and fallopian tubes, crucial components of the female reproductive system.

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Wolffian Ducts (Males)

These ducts, in males, develop into the epididymis and vas deferens, playing a vital role in sperm storage and transportation.

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Anaphase I (Meiosis)

This phase of meiosis is characterized by the separation of homologous chromosomes, resulting in daughter cells with half the number of chromosomes.

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Spermatogenesis

The process of sperm cell formation, where one diploid germ cell produces four haploid, functional sperm cells.

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First Meiotic Division (Oogenesis)

The first meiotic division during oogenesis, resulting in one secondary oocyte (which can potentially be fertilized) and one polar body (typically non-functional).

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Fertilization

The site where fertilization normally takes place, where the sperm encounters and fertilizes the oocyte.

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Zona Pellucida

The outer layer of the egg that serves as a protective barrier and also plays a role in preventing polyspermy (multiple sperm fertilizing one egg).

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Sertoli Cells

These cells, located in the testes, support and nourish developing sperm cells, playing a key role in spermatogenesis.

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Epiblast and Hypoblast

The inner cell mass of the blastocyst gives rise to these two layers, which eventually form the entire embryo.

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Notochord

This rod-like structure, formed from the mesoderm, plays a crucial role in inducing the development of the central nervous system.

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Somite Formation

The formation of paired blocks of mesoderm that develop into vertebrae, ribs, and muscles.

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Week 4 of Embryonic Development

This week marks the formation of the basic body plan with the appearance of heart, neural tube, and somites, laying the foundation for further development.

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Day 22 of Embryonic Development

The heart begins to beat, marking an important stage in circulatory system development.

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Fetal Period

The fetal period is characterized by rapid growth and maturation of organs, leading to the development of a fully functional fetus.

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Placenta

The placenta is essential for the exchange of nutrients, gases, and waste products between the mother and fetus, supporting fetal growth and development.

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Amniotic Fluid

The amniotic fluid provides a cushioning environment for the fetus, allowing for essential fetal movement and growth.

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Down Syndrome

A chromosomal abnormality most commonly associated with maternal age over 35 years, highlighting the importance of prenatal testing in older women.

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Fetal Alcohol Syndrome

A range of symptoms that manifests in a child exposed to alcohol during pregnancy, including developmental delays and facial abnormalities.

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Amniocentesis

A prenatal test that allows for the diagnosis of fetal chromosomal abnormalities, such as Down syndrome, by analyzing amniotic fluid.

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Non-invasive Prenatal Testing (NIPT)

A prenatal test that analyzes fetal DNA from maternal blood, offering a non-invasive method to detect chromosomal abnormalities such as Down syndrome.

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Study Notes

Fetal Development

  • Fetal Period: The period from the 9th week of gestation to birth.
  • First Trimester: Weeks 1-12 of pregnancy.
  • Cephalic Presentation: The fetus' head is positioned down in the uterus.
  • Mesonephric Ducts (Males): Develop into the vas deferens.
  • Mullerian Ducts (Females): Develop into the uterus.
  • Sperm Production: Occurs in the testes.
  • Meiosis: The process of cell division that produces gametes (sperm or egg).
  • Meiosis I Phases: Prophase I (crossing-over occurs), Metaphase I, Anaphase I (homologous chromosomes separate), and Telophase I.
  • Meiosis II Phases: Prophase II, Metaphase II, Anaphase II (sister chromatids separate), Telophase II.
  • Gamete Chromosome Number: 23 chromosomes.
  • Fertilization Steps: Sperm penetrates the egg's cytoplasm; the sperm undergoes the acrosomal reaction; the fertilized egg begins mitosis, and the zygote implants in the uterine lining.
  • Uterine Changes: The uterine mucosa thickens in response to fertilization.
  • Embryonic Development Structure: Amniotic cavity forms in the second week of embryonic development.
  • Germ Layers: Ectoderm, Mesoderm, Endoderm.
  • Neural Tube Formation: Occurs during neurulation.
  • Heart Beat: Begins around week 3.
  • Limb Formation: First sign occurs during week 4.
  • Second Trimester Characteristics: Rapid weight gain, and fat deposition; development of heart chambers.
  • Fetal Membranes (Not a Fetal Membrane): Placenta.
  • Fetal Membranes: Amnion, Chorion, Allantois.
  • Placental Barrier: Syncytiotrophoblast and cytotrophoblast.
  • Teratogens: Substances that can cause birth defects, such as alcohol, thalidomide, and retinoic acid.
  • Fetal Period Organ System: Respiratory system.
  • Amniotic Fluid Production: Primarily by fetal kidneys.
  • Embryonic Periods: The development of the brain and initial stages of organs.
  • Chorionic Villi: Important for nutrient exchange, and producing hCG.
  • Prenatal Testing:
    • Ultrasound: Used to assess fetal development and size, fetal structure.
    • Chorionic Villus Sampling (CVS): Done during 12-14 weeks for genetic abnormalities.
    • Amniocentesis: Done in the 15-20 weeks for genetic disorders.
    • Non-invasive Prenatal Testing (NIPT): Analyzes fetal DNA in maternal blood for genetic analysis.
    • Carrier Screening: Identifies if a parent carries a genetic trait that could affect the baby.
  • Genetic Disorders: Conditions caused by genetic mutations, such as Neural Tube Defects, Down Syndrome, Spina Bifida, Cleft Lip and Palate, Cystic Fibrosis et al..
  • Maternal Age and Genetic Conditions: Down syndrome is often associated with older mothers.
  • Abnormal Placenta Location: Low-lying placenta in the 20 weeks of pregnancy. This may result in early-term labor.
  • Fetal Length at 3rd Trimester End: Approximately 50 cm.
  • Structure Responsible for Nutrient/Waste Exchange: Placenta.
  • Amniotic Fluid Function: Cushions the fetus; helps maintain a constant temperature, assists in lung development.
  • First Event after Fertilization: Activation of egg metabolism.
  • Attachment Site in Implantation: Syncytiotrophoblast.
  • Umbilical Cord Composition: One artery and two veins.
  • Teratogen Associated with Limb Defects: Thalidomide.
  • Teratogen Associated with Cleft Palate: Retinoic acid

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Description

This quiz explores key concepts in fetal development, covering stages from the first trimester to birth. It includes topics such as meiosis, gamete formation, and uterine changes during pregnancy. Test your knowledge on the details of fetal growth and the biological processes involved.

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