Fertilization, Cleavage, and Implantation
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Questions and Answers

Which component of the placental membrane is responsible for forming the endothelial lining of fetal vessels?

  • Cytotrophoblast
  • Endothelial lining (correct)
  • Syncytiotrophoblast
  • Primary mesoderm
  • What substance is deposited on the outer surface of the placental membrane to decrease permeability at the end of pregnancy?

  • Placental hormones
  • Fibrinoid material (correct)
  • Fibrinogen
  • Collagen fibers
  • Which of the following correctly describes the fetal blood flow regarding the umbilical arteries?

  • They carry nutrient-rich blood from the placenta
  • They carry CO2 and waste products from the fetus to the placenta (correct)
  • They are responsible for hormone transport to the fetus
  • They transport oxygen-rich blood to the fetus
  • Which process does NOT occur via the placental barrier?

    <p>Transfer of toxic substances (D)</p> Signup and view all the answers

    What are the typical components of a full-term umbilical cord?

    <p>Two arteries and one vein (D)</p> Signup and view all the answers

    What is the earliest stage of human development after fertilization?

    <p>Stage of the male and female pronuclei (D)</p> Signup and view all the answers

    What happens to the zona pellucida before the early blastocyst stage?

    <p>It disappears completely. (A)</p> Signup and view all the answers

    What is the primary role of the syncytiotrophoblast during implantation?

    <p>To produce enzymes that erode uterine tissues. (D)</p> Signup and view all the answers

    By which day after fertilization does the blastocyst typically begin the implantation process?

    <p>6th day (C)</p> Signup and view all the answers

    Which layer of the endometrium is referred to as the decidua after implantation?

    <p>Compact layer (A)</p> Signup and view all the answers

    What is the function of the trophoblast after fertilization?

    <p>To differentiate into cytotrophoblast and syncytiotrophoblast. (B)</p> Signup and view all the answers

    Which of the following best describes the advanced morula stage?

    <p>A structure containing 12 to 16 blastomeres. (A)</p> Signup and view all the answers

    What significant change occurs in the embryonic period during organogenesis?

    <p>Conversion of the flat trilaminar embryonic disc into a cylindrical embryo (A)</p> Signup and view all the answers

    What is a potential outcome of caudal dysgenesis?

    <p>Fusion of the lower limbs (B)</p> Signup and view all the answers

    Which germ layer is primarily involved in forming the urogenital system?

    <p>Mesoderm (D)</p> Signup and view all the answers

    During which week does the primitive streak begin to regress during embryonic development?

    <p>End of the fourth week (D)</p> Signup and view all the answers

    What is sacrococcygeal teratoma characterized by?

    <p>Presence of pluripotent cells proliferating in the sacrococcygeal region (D)</p> Signup and view all the answers

    What term describes the sensitivity of embryos to teratogens during their development?

    <p>Critical period (B)</p> Signup and view all the answers

    What consequence might result from insufficient mesoderm formation?

    <p>Hypoplasia and vertebral abnormalities (B)</p> Signup and view all the answers

    Which type of embryonic folding is related specifically to the rapid growth of the central nervous system?

    <p>Cephalocaudal folding (B)</p> Signup and view all the answers

    What is the primary focus of embryonic folding during the early stages of development?

    <p>Conversion of the embryo's shape (B)</p> Signup and view all the answers

    What are the two layers into which the trophoblast differentiates during the second week of development?

    <p>Syncytiotrophoblast and cytotrophoblast (A)</p> Signup and view all the answers

    Which term describes the extraembryonic mesoderm that covers the yolk sac?

    <p>Splanchnopleuric mesoderm (C)</p> Signup and view all the answers

    Which statement best describes the potency of embryonic stem cells?

    <p>They can differentiate into any other type of cell. (C)</p> Signup and view all the answers

    What occurs during the late second week of embryonic development?

    <p>Completion of implantation (D)</p> Signup and view all the answers

    What is a critical property of stem cells that allows them to regenerate damaged tissues?

    <p>Ability to differentiate into various cell types (D)</p> Signup and view all the answers

    Which type of mesoderm is associated with the extraembryonic layer of the amnion?

    <p>Somatopleuric mesoderm (A)</p> Signup and view all the answers

    During which developmental stage does the hypoblast begin to spread beneath the cytotrophoblast?

    <p>Implanted blastocyst at 6 days (B)</p> Signup and view all the answers

    Which of the following is a source of adult stem cells?

    <p>Cells harvested from bone marrow (C)</p> Signup and view all the answers

    What does self-renewal in stem cells refer to?

    <p>The ability to maintain the undifferentiated state through division (C)</p> Signup and view all the answers

    What is the primary function of the allantois during embryonic development?

    <p>Formation of umbilical blood vessels (D)</p> Signup and view all the answers

    Meckel’s diverticulum is primarily caused by which of the following?

    <p>Persistence of a part of the yolk sac (A)</p> Signup and view all the answers

    Which congenital anomaly results from the obliteration of the intraembryonic part of the allantois?

    <p>Urachal cyst (C)</p> Signup and view all the answers

    How far is Meckel’s diverticulum typically located from the ileocaecal junction?

    <p>2 feet (C)</p> Signup and view all the answers

    What abnormality is associated with the urachus after birth?

    <p>Median umbilical ligament (D)</p> Signup and view all the answers

    Which of the following anomalies is not typically associated with the allantois?

    <p>Fibrous band obstruction (C)</p> Signup and view all the answers

    What percentage of the population is estimated to have Meckel’s diverticulum?

    <p>2% (A)</p> Signup and view all the answers

    During embryonic development, the yolk stalk's persistence is most likely to result in which condition?

    <p>Meckel’s diverticulum (B)</p> Signup and view all the answers

    Which condition develops from an issue with the cloacal membrane during embryonic folding?

    <p>Allantois defect (B)</p> Signup and view all the answers

    What is the fate of the distal portion of the allantois after embryonic development?

    <p>Forms part of the urinary system (A)</p> Signup and view all the answers

    Flashcards

    Fertilization time

    Approximately 12-24 hours after ovulation

    Two-cell stage age

    Approximately 30 hours after fertilization

    Morula stage

    12-16 blastomeres, 3 days post fertilization

    Blastocyst formation

    Stage where the zona pellucida disappears and the blastocyst hatches

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    Implantation start

    End of week 1 (6th day), completes around day 11.

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    Implantation site

    Anterior or posterior uterine wall, near the middle line.

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    Decidua definition

    Endometrium after blastocyst implantation

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    Extraembryonic mesoderm layers

    Two layers of mesoderm outside the embryo: somatopleuric and splanchnopleuric.

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    Trophoblast layers

    Outer layer of the blastocyst, differentiating into two layers.

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    Inner cell mass layers

    Inner cell mass differentiates into two layers: epiblast and hypoblast.

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    Primary mesoderm differentiation

    Primary mesoderm splits into somatopleuric and splanchnopleuric.

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    Blastocyst Stage

    The stage of embryonic development after the morula, characterized by the formation of a blastocoel and two layers.

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    Embryonic stem cells

    Undifferentiated cells capable of self-renewal and differentiation into various cell types.

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    Totipotent stem cells

    Stem cells capable of differentiating into any type of cell in the body.

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    Self-renewal (stem cells)

    The ability of stem cells to divide and maintain their undifferentiated state.

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    Potency (stem cells)

    The ability of stem cells to differentiate into different cell types.

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    First week product

    Mature blastocyst

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    Embryonic folding

    The process of converting the flat trilaminar embryonic disc into a cylindrical embryo.

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    Time of embryonic folding

    Starts at the end of the third week and completes by the fourth week.

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    Cephalocaudal folding

    Folding along the head-to-tail axis, caused by rapid growth of the central nervous system.

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    Head fold

    The bending of the embryo at the head end, forming the future head region.

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    Tail fold

    The bending of the embryo at the tail end, forming the future buttocks and tail region.

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    Lateral folding

    Folding along the sides of the embryo, bringing the lateral edges closer together.

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    Derivatives of ectoderm

    The ectoderm gives rise to the outer structures like skin, hair, nails, nervous system, and sensory organs.

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    Derivatives of Mesoderm

    The middle layer, mesoderm, forms muscles, bones, heart, blood, and internal organs.

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    Derivatives of Endoderm

    The innermost layer, endoderm, forms the lining of the digestive system and respiratory system.

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    Importance of Embryonic Folding

    It is crucial for the formation of the body's major axes and internal structures.

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    Placental Circulation

    The exchange of materials between the mother and fetus through the placenta. Oxygen, nutrients, and waste products are exchanged across the placental barrier.

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    Placental Barrier

    The protective membrane separating the fetal blood from the maternal blood within the placenta. It allows for the exchange of essential substances but prevents mixing of blood.

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    What are the layers of the placental barrier?

    The placental barrier initially comprises four layers: (a) endothelial lining of fetal vessels, (b) primary mesoderm, (c) cytotrophoblast, and (d) syncytiotrophoblast. These layers thin later in pregnancy, enhancing exchange efficiency.

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    What is Wharton's Jelly?

    A gelatinous substance within the umbilical cord that protects and supports the umbilical vessels (two arteries and one vein) carrying blood to and from the fetus.

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    Primitive Umbilical Cord

    The initial structure formed during embryonic folding, containing the body stalk (allantois and umbilical blood vessels), yolk stalk (vitelline blood vessels), and remnants of extra embryonic coelom.

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    Meckel's diverticulum

    A small pouch-like protrusion on the small intestine caused by the persistence of a part of the yolk sac.

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    Fibrous band

    A cord-like structure formed when the yolk stalk disappears, potentially leading to intestinal obstruction.

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    Vitelline sinus

    An abnormal connection between the yolk sac and the small intestine, often associated with bleeding.

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    Vitelline cyst

    A fluid-filled sac formed when the vitelline duct doesn't close properly.

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    Allantois

    A small pouch that extends from the yolk sac into the connecting stalk, later contributing to the formation of the urinary bladder.

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    Uracus

    A remnant of the allantois, forming the median umbilical ligament after birth.

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    Urachal cyst

    Abnormal fluid-filled sac formed when the urachus fails to close completely.

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    Urachal sinus

    An abnormal opening between the bladder and the belly button, caused by the urachus not closing completely.

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    Urachal fistula

    An abnormal connection between the bladder and the belly button, allowing urine to leak out through the belly button.

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    Median umbilical ligament

    The obliterated urachus, connecting the apex of the urinary bladder to the belly button after birth.

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    Study Notes

    Fertilization, Cleavage, and Implantation

    • Fertilization is the fusion of mature sperm and ovum, forming a zygote.
    • Fertilization occurs in the ampullary part of the uterine tube.
    • Sperm must undergo capacitation and acrosome reaction to fertilize the oocyte.
    • Sperm structure includes a head (nucleus and acrosome), midpiece (mitochondria), and tail (flagellum).
    • The acrosome contains enzymes (acrosin and others) to penetrate the zona pellucida.
    • Sperm motility relies on mitochondria and flagella.
    • Mitochondrial inheritance is solely maternal.

    Phases of Fertilization

    • Phase 1: Penetration of the corona radiata
    • Phase 2: Penetration of the zona pellucida
    • Phase 3: Fusion of oocyte and sperm cell membranes

    Results of Fertilization

    • Restoration of diploid number of chromosomes.
    • Determination of the sex of the new individual.
    • Initiation of cleavage; the oocyte usually degenerates within 24 hours after ovulation without fertilization.

    Cleavage

    • A series of mitotic divisions increasing the number of cells.
    • Occurs in the uterine tube, medial to the ampulla.
    • Stages: morula stage

    Blastocyst Formation

    • Morula develops into a fluid-filled blastocyst.
    • Inner cell mass (ICM) forms the embryo.
    • Trophoblast forms the fetal part of the placenta.
    • Blastocyst implants in the uterine wall.
    • Zona pellucida disappears before implantation.

    Implantation

    • Penetration of the blastocyst into the uterine endometrium.
    • Occurs approximately 6 to 11 days after fertilization.
    • Normal site is in the endometrium of the anterior or posterior wall of the uterus, near the middle line.
    • Trophoblast differentiates into cytotrophoblast and syncytiotrophoblast.
    • Syncytiotrophoblast erodes uterine tissues, allowing blastocyst embedding.
    • Implantation completes the formation of the decidua.

    The Decidua

    • The endometrium after blastocyst implantation.
    • Types: decidua basalis, capsularis, and parietalis.

    Clinical Correlates

    • Abnormal Implantation (Ectopic Pregnancy): Implantation outside the uterus (typically fallopian tube).
    • Abnormal sites of implantation: Uterine ectopic pregnancy (cornu, lower segment, cervix); extra-uterine pregnancy (fallopian tube, ovary).
    • Placenta previa: Implantation of the blastocyst in the lower segment of the uterus.

    The Second and Third Week of Development

    • Blastocyst embedding in the uterine wall.
    • Trophoblast differentiates into cytotrophoblast and syncytiotrophoblast.
    • Inner cell mass differentiates into epiblast and hypoblast.
    • Formation of the amniotic cavity and yolk sac.
    • Formation of the bilaminar disc (epiblast and hypoblast).

    The Embryonic Period

    • Embryonic period (3rd-8th week).
    • Major organogenesis occurs.
    • Folding of the embryo.
    • Cephalocaudal and lateral folding.
    • Somitogenesis, developing somites, paired blocks of mesoderm.

    Differentiation of the Mesoderm

    • Forms paraxial, intermediate, and lateral plate mesoderm.
    • Paraxial mesoderm gives rise to somites.
    • Development of the neural tube begins.
    • Intermediate mesoderm gives rise to the excretory and reproductive systems.
    • Lateral plate mesoderm gives rise to the serosal membranes and several parts of the circulatory system.

    Endodermal Derivatives

    • Epithelial lining of the gastrointestinal tract, respiratory tract (lungs), and urinary bladder.
    • Parenchyma of the thyroid, parathyroids, liver, and pancreas.

    Ectodermal Derivatives

    • Central nervous system
    • Peripheral nervous system
    • Sensory epithelium of ear, nose, and eyes
    • Skin, including hair and nails
    • Pituitary, mammary, sweat glands, and tooth enamel.

    Neurulation

    • Formation of the neural tube (primordium of the central nervous system).
    • Development of the neural crest.

    Clinical Applications

    • Disruption in gastrulation (sirenomelia) due to insufficient mesoderm formation.
    • Sacrococcygeal teratomas.

    The Fetal Membranes

    • Development of chorionic villi.
    • Formation of the chorionic plate, decidual plate, and intervillous spaces.
    • Types of villi (primary, secondary, tertiary).
    • Chorion frondosum (villi on the fetal side) and chorion laeve (smooth fetal surface).

    The Placenta

    • Fetal and maternal portions (chorion frondosum and decidua basalis).
    • Formation of intervillous spaces.
    • Nutrient and waste exchange between maternal and fetal blood.
    • Placental barrier.

    Umbilical Cord

    • Structures: arteries, vein, and Wharton's jelly.
    • Connection to the fetus and placenta.
    • Formation of the umbilical cord from the body stalk.
    • Obliteration of the yolk stalk and allantois.
    • Components: umbilical arteries, umbilical vein, and Wharton's jelly.

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    Description

    This quiz explores the processes of fertilization, cleavage, and implantation in human reproduction. It covers the phases of fertilization, sperm structure, and the results after fertilization. Test your knowledge on these essential biological concepts.

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