Factors Contributing to Inflammatory Bowel Disease (IBD)

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Questions and Answers

Which statement about genetic factors in inflammatory bowel disease (IBD) is correct?

Genetic predisposition contributes to the development of IBD.

Which of the following statements about familial IBD is true?

Familial IBD is more common among relatives of patients with IBD than in the general population.

In the context of Crohn's disease and ulcerative colitis, which statement about genetic factors is correct?

Genetic factors play a more prominent role in Crohn's disease than in ulcerative colitis.

Which of the following genes is associated with susceptibility to inflammatory bowel disease (IBD)?

NOD2/CARD15 gene Signup and view all the answers

What is the primary function of the NOD2/CARD15 protein?

Prevents the entry of microbes into the intestinal wall and regulates innate immune responses. Signup and view all the answers

What is the consequence of a defective NOD2/CARD15 protein?

It allows the entry of luminal microbes into the intestinal wall and stimulates inflammatory reactions. Signup and view all the answers

Which statement about genetic factors in Crohn's disease is correct?

Crohn's disease has a strong genetic component, with family history being an important risk factor. Signup and view all the answers

In Crohn's disease, which of the following statements about genetic susceptibility is true?

Multiple susceptibility genes interact with environmental factors to contribute to the disease. Signup and view all the answers

Which of the following statements regarding familial Crohn's disease is accurate?

Individuals with a family history of Crohn's disease have an increased risk of developing the disease. Signup and view all the answers

Which of the following statements about genetic factors in inflammatory bowel diseases (IBD) is true?

Genetic factors contribute to the development of both Crohn's disease and ulcerative colitis, but different genes are involved. Signup and view all the answers

Which of the following statements about the genetic basis of Crohn's disease is correct?

Crohn's disease is caused by a combination of genetic and environmental factors. Signup and view all the answers

Which of the following statements regarding genetic factors in inflammatory bowel diseases (IBD) is accurate?

Genetic factors contribute to the development of IBD, but different genes are involved in Crohn's disease and ulcerative colitis. Signup and view all the answers

What is the primary cause of peptic ulcers according to the passage?

Infection with H. pylori bacteria Signup and view all the answers

How do H. pylori bacteria contribute to the development of peptic ulcers?

They secrete enzymes that disrupt the mucosal barrier Signup and view all the answers

According to the passage, which of the following is not a factor contributing to the pathogenesis of peptic ulcers?

Genetic predisposition Signup and view all the answers

How do neuroendocrine factors contribute to the development of peptic ulcers?

They disrupt the normal regulation of gastric acid secretion Signup and view all the answers

What is the proposed mechanism by which the gastric acid of ulcer patients can lead to mucosal ulcerations?

The acid causes a back-diffusion of hydrogen ions, damaging the glands Signup and view all the answers

Which of the following factors is not mentioned in the passage as contributing to the pathogenesis of peptic ulcers?