29 Questions
What is a common issue that might arise in a hemophilia A patient if a factor assay does not match expected levels after a therapeutic infusion of factor concentrate?
Presence of spontaneous inhibitors
What is the purpose of the Whole Blood Clot Lysis Time test?
Detecting increased fibrinolysis
What happens when a clot in the bloodstream detaches and circulates, potentially leading to obstructions in organs?
Increased risk of pulmonary embolism
Which antibodies are responsible for neutralizing the function of a specific factor in hemophilia patients?
Spontaneous inhibitors
In the context of fibrinolysis, what is the role of excess systemic fibrinolysis?
Leading to clot lysis before 48 hours
Which test is specifically used to detect high increases in fibrinolytic activity?
Whole Blood Clot Lysis Time Test
What is the primary function of fibrinolysis?
To dissolve the clot
Why do the results of more concentrated dilutions (1:10, 1:20) tend to be lower in the presence of inhibitors like Lupus inhibitors or heparin?
The inhibitors are diminished by dilution
In the provided table, which dilution resulted in an activity percentage of 6.3%?
1:160
What happens when there is hyperactivity of fibrinolysis?
Clots dissolve more slowly
What is the significance of performing coagulation tests on a timerometer?
To assess clotting time
Which tube from the table had a dilution resulting in 25% activity?
#3
What is the next step if no correction is seen in mixing studies for a patient with factor deficiency?
Check for antiphospholipid antibodies
Which of the following is used to determine the plasma concentration of factors II, V, VII, and X?
Prothrombin time (PT)
What is the normal range of activity for factors II, V, VII, and X in plasma?
50-150%
In factor V deficiency, what is used as a reference plasma for testing?
Normal control plasma
What does the amount of correction by patient's plasma in a prothrombin time test correlate with?
Factor activity level
What should be checked if specific factor assays reveal low concentration of a particular factor?
Factor inhibitors
What is the principle behind the Ethanol Gelation Test?
Fibrin soluble monomers dissociate in the presence of 50% ethanol, leading to polymerization and gel formation.
What is the significance of a positive result in the Latex D-Dimer Assay?
It indicates the presence of fibrin degradation products, specifically D-dimer.
Which of the following conditions is NOT associated with a decreased level of plasminogen?
Disseminated Intravascular Coagulation (DIC)
What is the purpose of the Plasminogen Assay?
To assess if there are any plasminogen deficiencies.
What is the reference interval for the Prothrombin Time (PT) mentioned in the text?
11 to 14 seconds
What is the significance of a positive result in the Latex Fibrin Degradation Product (FDP) Assay?
It indicates the presence of fibrin degradation products.
What is the substrate that the enzyme peroxidase acts on in the presence of hydrogen peroxide?
OPD (Orthophenylenediamine)
What is the proportion of total protein S antigen in the plasma that is normally bound to C4b?
60%
What is the role of the free protein S in the plasma?
It serves as a cofactor for the anticoagulant effects of activated protein C.
What happens to the protein S bound to C4b BP?
It is precipitated with polyethylene glycol.
Which of the following is not a cause of acquired deficiency of protein S?
Hereditary thrombophilia
Test your knowledge on diagnosing factor deficiency with prolonged aPTT through mixing studies. Learn how to differentiate between vW disease, specific factor deficiencies, antiphospholipid antibodies, and factor inhibitors.
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