Factor Deficiency Diagnosis Quiz
29 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is a common issue that might arise in a hemophilia A patient if a factor assay does not match expected levels after a therapeutic infusion of factor concentrate?

  • Presence of spontaneous inhibitors (correct)
  • Decreased white blood cell count
  • Excess red blood cell production
  • Increased platelet count
  • What is the purpose of the Whole Blood Clot Lysis Time test?

  • Detecting increased fibrinolysis (correct)
  • Measuring red blood cell count
  • Determining white blood cell activity
  • Assessing platelet function
  • What happens when a clot in the bloodstream detaches and circulates, potentially leading to obstructions in organs?

  • Enhanced clot dissolution process
  • Decreased risk of clot-related issues
  • Formation of aneurysm in the lungs
  • Increased risk of pulmonary embolism (correct)
  • Which antibodies are responsible for neutralizing the function of a specific factor in hemophilia patients?

    <p>Spontaneous inhibitors</p> Signup and view all the answers

    In the context of fibrinolysis, what is the role of excess systemic fibrinolysis?

    <p>Leading to clot lysis before 48 hours</p> Signup and view all the answers

    Which test is specifically used to detect high increases in fibrinolytic activity?

    <p>Whole Blood Clot Lysis Time Test</p> Signup and view all the answers

    What is the primary function of fibrinolysis?

    <p>To dissolve the clot</p> Signup and view all the answers

    Why do the results of more concentrated dilutions (1:10, 1:20) tend to be lower in the presence of inhibitors like Lupus inhibitors or heparin?

    <p>The inhibitors are diminished by dilution</p> Signup and view all the answers

    In the provided table, which dilution resulted in an activity percentage of 6.3%?

    <p>1:160</p> Signup and view all the answers

    What happens when there is hyperactivity of fibrinolysis?

    <p>Clots dissolve more slowly</p> Signup and view all the answers

    What is the significance of performing coagulation tests on a timerometer?

    <p>To assess clotting time</p> Signup and view all the answers

    Which tube from the table had a dilution resulting in 25% activity?

    <p>#3</p> Signup and view all the answers

    What is the next step if no correction is seen in mixing studies for a patient with factor deficiency?

    <p>Check for antiphospholipid antibodies</p> Signup and view all the answers

    Which of the following is used to determine the plasma concentration of factors II, V, VII, and X?

    <p>Prothrombin time (PT)</p> Signup and view all the answers

    What is the normal range of activity for factors II, V, VII, and X in plasma?

    <p>50-150%</p> Signup and view all the answers

    In factor V deficiency, what is used as a reference plasma for testing?

    <p>Normal control plasma</p> Signup and view all the answers

    What does the amount of correction by patient's plasma in a prothrombin time test correlate with?

    <p>Factor activity level</p> Signup and view all the answers

    What should be checked if specific factor assays reveal low concentration of a particular factor?

    <p>Factor inhibitors</p> Signup and view all the answers

    What is the principle behind the Ethanol Gelation Test?

    <p>Fibrin soluble monomers dissociate in the presence of 50% ethanol, leading to polymerization and gel formation.</p> Signup and view all the answers

    What is the significance of a positive result in the Latex D-Dimer Assay?

    <p>It indicates the presence of fibrin degradation products, specifically D-dimer.</p> Signup and view all the answers

    Which of the following conditions is NOT associated with a decreased level of plasminogen?

    <p>Disseminated Intravascular Coagulation (DIC)</p> Signup and view all the answers

    What is the purpose of the Plasminogen Assay?

    <p>To assess if there are any plasminogen deficiencies.</p> Signup and view all the answers

    What is the reference interval for the Prothrombin Time (PT) mentioned in the text?

    <p>11 to 14 seconds</p> Signup and view all the answers

    What is the significance of a positive result in the Latex Fibrin Degradation Product (FDP) Assay?

    <p>It indicates the presence of fibrin degradation products.</p> Signup and view all the answers

    What is the substrate that the enzyme peroxidase acts on in the presence of hydrogen peroxide?

    <p>OPD (Orthophenylenediamine)</p> Signup and view all the answers

    What is the proportion of total protein S antigen in the plasma that is normally bound to C4b?

    <p>60%</p> Signup and view all the answers

    What is the role of the free protein S in the plasma?

    <p>It serves as a cofactor for the anticoagulant effects of activated protein C.</p> Signup and view all the answers

    What happens to the protein S bound to C4b BP?

    <p>It is precipitated with polyethylene glycol.</p> Signup and view all the answers

    Which of the following is not a cause of acquired deficiency of protein S?

    <p>Hereditary thrombophilia</p> Signup and view all the answers

    More Like This

    Iron Absorption
    7 questions

    Iron Absorption

    SpellbindingGreen avatar
    SpellbindingGreen
    Use Quizgecko on...
    Browser
    Browser