Clot Dissolution and FACTOR XIII Deficiency
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Questions and Answers

Which disease is associated with acquired deficiency of FACTOR XIII?

  • Hemophilia A
  • Von Willebrand disease
  • Hemochromatosis
  • Henoch-Schonlein purpura (correct)

What is the sensitivity of clot dissolution in 5M urea or monochloroacetic acid?

  • 30% (correct)
  • 40%
  • 20%
  • 50%

Which type of deficiency has low or absent plasma fibrinogen antigen levels?

  • Type II FACTOR XIII deficiency
  • Quantitative fibrinogen deficiency
  • Type I FACTOR XIII deficiency
  • Type III FACTOR XIII deficiency (correct)

What is the common cause of acquired deficiency of FACTOR XIII?

<p>Isoniazid treatment for tuberculosis (D)</p> Signup and view all the answers

What is the most appropriate replacement therapy for most patients with FXIII deficiency due to its long half-life?

<p>Fresh frozen plasma (B)</p> Signup and view all the answers

Which type of deficiency has disproportionately low function activity despite normal or reduced antigen levels?

<p>Quantitative fibrinogen deficiency (C)</p> Signup and view all the answers

Which type of hemostasis disorder is characterized by a delayed onset of bleeding after trauma or surgery?

<p>Secondary hemostasis (C)</p> Signup and view all the answers

In which of the following sites is bleeding less common in secondary hemostasis disorders?

<p>Joints and muscles (D)</p> Signup and view all the answers

Which test estimates fibrinogen concentration by measuring the time taken for plasma to clot upon addition of thrombin?

<p>Thrombin time (B)</p> Signup and view all the answers

Which factor deficiency is associated with factor XIII deficiency?

<p>Factor V deficiency (A)</p> Signup and view all the answers

What does thrombin attack directly to convert it to fibrin?

<p>Fibrinogen (D)</p> Signup and view all the answers

Which test is used for estimating the fibrinogen concentration in a patient?

<p>Thrombin time (A)</p> Signup and view all the answers

Which factor deficiency is associated with amyloidosis?

<p>Factor X (B)</p> Signup and view all the answers

In what percent range is considered mild hemophilia?

<p>5% to 20% (B)</p> Signup and view all the answers

Which synthetic analog of ADH increases plasma Factor VIII levels?

<p>DDAVP (C)</p> Signup and view all the answers

Which factor deficiency is the most common rare inherited coagulation disorder?

<p>Factor XI (C)</p> Signup and view all the answers

What is the factor deficiency often associated with primary amyloidosis?

<p>Factor X (D)</p> Signup and view all the answers

For what disorder is Tissue Factor Deficiency not observed?

<p>Hemophilia (A)</p> Signup and view all the answers

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