Hemophilia A: Factor VIII Deficiency Quiz

Factor VIII

Factor VIII

Severe molecular defects (large deletions, intron 22 inversions, nonsense mutations) or milder molecular defects like point mutations

<p>Slows the rate of FXa generation</p> Signup and view all the answers

<p>Defective fibrin stabilization due to inadequate fibrin generation</p> Signup and view all the answers

<p>Load-bearing joints (ankles, knees, elbows) and intracapsular bleeds</p> Signup and view all the answers

<p>CNS bleeding</p> Signup and view all the answers

<p>Normal to low Hb/hct values, normal platelet count</p> Signup and view all the answers

<p>Easy bruising, inadequate clotting of traumatic or mild injury, spontaneous hemorrhage in severe cases</p> Signup and view all the answers

<p>Initiate thrombin formation for adequate fibrin generation</p> Signup and view all the answers