week 11 & 12 exam notes
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Questions and Answers

What was a primary ethical violation in the Tuskegee Syphilis Study?

  • Participants were promised health care but received none. (correct)
  • Participants were paid for their involvement.
  • The research was conducted without a scientific basis.
  • Participants were fully informed about the study.
  • Which principle is included in the Nuremberg Code regarding research risks?

  • All potential risks must be disclosed to participants.
  • Participants must be monitored for physical and mental suffering.
  • The risk of participation should never exceed the potential benefits. (correct)
  • Only reputable sponsors can conduct research.
  • What action was taken by Dr. Chester Southam in 1963 that raised ethical concerns?

  • He published false results in a medical journal.
  • He injected geriatric patients with live cancer cells without consent. (correct)
  • He withheld medical treatment from participants.
  • He conducted unauthorized experiments on healthy individuals.
  • Which guideline from the Nuremberg Code emphasizes the importance of informed consent?

    <p>Free and informed consent is essential.</p> Signup and view all the answers

    What principle was highlighted by the Declaration of Helsinki regarding experimental procedures?

    <p>Independent review of study protocols is mandatory.</p> Signup and view all the answers

    Which issue related to ethical research was exemplified by Stanley Milgram's experiments?

    <p>Participants were deceived about the nature of the experiment.</p> Signup and view all the answers

    What is a major limitation of the Nuremberg Code?

    <p>It is not legally binding.</p> Signup and view all the answers

    What type of research focuses on describing how things are rather than explaining why they are?

    <p>Descriptive research</p> Signup and view all the answers

    Which of the following types of research involves measuring variables without manipulation?

    <p>Correlational research</p> Signup and view all the answers

    What is the range for a small correlation coefficient according to the general rules for reporting correlations?

    <p>0.1 – 0.3</p> Signup and view all the answers

    If a correlation coefficient (r) is 0.219, how strong is this relationship considered?

    <p>Weak</p> Signup and view all the answers

    What does the coefficient of determination (r²) represent?

    <p>The proportion of variance in one variable accounted for by another</p> Signup and view all the answers

    What is one principle related to the ethical conduct of human research?

    <p>Participants should be shown respect and protection.</p> Signup and view all the answers

    What is indicated by a negative relationship between two variables?

    <p>One variable increases while the other decreases</p> Signup and view all the answers

    What problem arises from not being able to ascertain the true cause of a relationship between two variables?

    <p>Directionality problem</p> Signup and view all the answers

    Which of the following is NOT a component of ethical approval for research involving humans?

    <p>Recruitment of researchers based on personal relationships.</p> Signup and view all the answers

    What does the principle of 'Replacement' refer to in the use of animals for research?

    <p>Using alternative methods when possible.</p> Signup and view all the answers

    Diederik Stapel was suspended due to misconduct involving which of the following?

    <p>Fabricating and manipulating data</p> Signup and view all the answers

    What is the primary goal of correlational research?

    <p>To describe the strength and direction of relationships between variables</p> Signup and view all the answers

    Which scenario exemplifies a conflict of interest?

    <p>A peer-reviewer has been friends with an author for years.</p> Signup and view all the answers

    What is considered a breach in the context of research misconduct?

    <p>Serious negligence or deliberation leading to harmful consequences.</p> Signup and view all the answers

    Which of the following actions may be required when investigating a complaint of research misconduct?

    <p>A discreet investigation.</p> Signup and view all the answers

    What is the primary goal in the supervision of research trainees?

    <p>Cultivating responsible research practices.</p> Signup and view all the answers

    What is the aim of the principle of 'Refinement' regarding animal research?

    <p>Minimizing pain, suffering, and distress experienced by animals.</p> Signup and view all the answers

    What must researchers do when they have a potential conflict of interest?

    <p>Declare and manage the conflict appropriately.</p> Signup and view all the answers

    Study Notes

    Ethics in Research

    • The Tuskegee Syphilis Study (1932-1972) involved 600 African-American agricultural workers who were promised healthcare as an incentive.
    • Participants were not diagnosed, advised, treated, or cured for syphilis, despite the availability of penicillin by 1947.
    • 128 participants died during this study.

    Nuremberg Code (1947)

    • The Nuremberg Code outlines 10 guidelines for the ethical treatment of human research participants.
    • These guidelines were established in response to the atrocities committed during the Nazi regime.
    • These guidelines are not legally binding.

    Unethical Research Practices

    • Dr. Chester Southam (1963) injected geriatric hospital patients with live liver cancer cells without their informed consent.
    • Stanley Milgram (1963) conducted a study where participants were led to believe they were administering shocks, inducing psychological distress and raising ethical concerns about deception and informed consent.

    Declaration of Helsinki (1964)

    • This document sets ethical principles for medical research involving human subjects.
    • It emphasizes the importance of independent review committees to evaluate research protocols.

    Australian Code for the Responsible Conduct of Research

    • Provides a framework for ethical research practices within universities and public sector institutions.
    • Covers various aspects of research conduct, including data management, supervision, publication, authorship, peer review, conflict of interest, and collaborations.

    National Statement on Ethical Conduct in Human Research

    • Outlines standards for the design, review, and conduct of human research.
    • Aims to promote ethical human research that respects and protects participants while fostering research that benefits the community.
    • Ethical approval is mandatory for any research involving human participants.
    • This includes surveys, interviews, focus groups, psychological testing, medical treatment, observation, access to personal documents, collection of bodily materials, and access to personal information.

    Animal Research

    • The use of live vertebrate animals in research requires ethical approval.
    • The Australian Code of Practice for the Care and Use of Animals for Scientific Purposes outlines principles for responsible animal research.
    • These principles include: Replacement (using alternative methods whenever possible), Reduction (minimizing the number of animals used), and Refinement (minimizing pain, suffering, and distress).

    Conflict of Interest

    • A conflict of interest arises when financial or personal considerations have the potential to compromise scientific or professional conduct.
    • Examples include researchers benefiting financially from a specific research outcome, researchers receiving undisclosed payments, peer reviewers favoring research similar to their own work, or personal relationships between researchers and participants.

    Research Misconduct

    • A "breach" refers to deviations from the Australian Code for the Responsible Conduct of Research.
    • Complaints of research misconduct require a response that may involve investigation, inquiry, and remedial actions.
    • Research misconduct occurs if it involves all of the following: an alleged breach of the Australian Code, deliberation or recklessness, and serious consequences.
    • Research misconduct includes fabrication, falsification, plagiarism, deception, failure to declare or manage a serious conflict of interest.
    • Diederik Stapel, a Dutch social psychologist, was suspended for fabricating and manipulating data, leading to the retraction of at least 57 publications.

    Research Strategies

    Descriptive Research

    • Aims to describe how things are, rather than explaining why they are.
    • Often uses observational and survey research.
    • Examples: What is the typical number of hours spent studying each week?

    Correlational Research

    • Goal is to describe the strength and direction of relationships between two or more variables.
    • It measures variables but doesn’t manipulate them.
    • Allows for predictions but cannot establish cause-and-effect.
    • Relationships can be positive (both variables change in the same direction), negative (variables change in opposite directions), linear, and/or non-linear.

    Pearson’s Correlation

    • A statistical method used to measure the strength and direction of a linear relationship between two variables.
    • Provides a correlation coefficient (r) which indicates the strength and direction of the relationship.
    • The coefficient of determination (r2) indicates the proportion of variation in one variable that is accounted for by the other.

    Terms to Use in Correlational Research

    • Association
    • Relation
    • Correlation
    • Prediction

    Experimental Research

    • Aims to identify cause-and-effect relationships by manipulating independent variables and measuring dependent variables.
    • Requires four key elements: manipulation, measurement, control, and comparison.

    Between-Subjects Design

    • Different participants are assigned to each treatment condition.
    • Vulnerable to individual difference threats to validity, but not time-related threats.

    Within-Subjects Design

    • The same participants are exposed to all treatment conditions.
    • Not vulnerable to individual differences threats to validity, but vulnerable to time-related threats.

    Extraneous Variables

    • Variables other than the independent and dependent variables in a study.
    • They can become confounding variables if they influence the dependent variable.

    Confounding Variables

    • Change systematically with the independent variable, influencing the dependent variable, making it difficult to determine the true effect of the independent variable.

    Control Strategies

    • Holding a variable constant: Reduces the possibility of a variable becoming confounding by restricting its range.
    • Matching: Balancing the levels of a variable across treatment conditions to ensure they are equivalent (e.g., using counterbalancing or ensuring equal representation across conditions).
    • Randomization: Utilizes random processes to avoid systematic relationships between variables, reducing the influence of extraneous variables.

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