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Questions and Answers
What is the therapeutic class of Etanercept (Enbrel)?
What is the therapeutic class of Etanercept (Enbrel)?
- Antipyretic
- Antiarthritic (correct)
- Antibiotic
- Analgesic
What is the pharmacologic class of Etanercept (Enbrel)?
What is the pharmacologic class of Etanercept (Enbrel)?
- Immunosuppressant
- Non-steroidal anti-inflammatory drug
- Corticosteroid
- TNF Blocker (correct)
What is the action of Etanercept (Enbrel)?
What is the action of Etanercept (Enbrel)?
Binds specifically to TNF and blocks its action with cell surface TNF receptors, reducing inflammatory and immune responses found in rheumatoid arthritis.
Which of the following are side effects of Etanercept (Enbrel)? (Select all that apply)
Which of the following are side effects of Etanercept (Enbrel)? (Select all that apply)
What are the indications for using Etanercept (Enbrel)? (Select all that apply)
What are the indications for using Etanercept (Enbrel)? (Select all that apply)
What type of drug interaction does Etanercept (Enbrel) have with antidiabetics?
What type of drug interaction does Etanercept (Enbrel) have with antidiabetics?
What is the route of administration for Etanercept (Enbrel)?
What is the route of administration for Etanercept (Enbrel)?
What patient teaching is important for Etanercept (Enbrel)?
What patient teaching is important for Etanercept (Enbrel)?
What are key nursing implications for Etanercept (Enbrel)?
What are key nursing implications for Etanercept (Enbrel)?
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Study Notes
Etanercept (Enbrel) Overview
- Therapeutic Class: Antiarthritic medication used primarily to manage inflammatory conditions.
Pharmacologic Class
- Classification: TNF Blocker, which interferes with tumor necrosis factor to reduce inflammation.
Mechanism of Action
- Action: Binds specifically to TNF, blocking its interaction with cell surface receptors, thus diminishing inflammatory and immune responses, particularly in rheumatoid arthritis.
Side Effects
- Potential Reactions:
- Malignancies
- Infections
- Development of antibodies
- Reactions at the injection site
- Gastrointestinal issues such as nausea and vomiting
- Pruritis (itching)
Indications
- Approved Conditions:
- Polyarticular juvenile idiopathic arthritis
- Rheumatoid arthritis
- Ankylosing spondylitis
- Psoriatic arthritis
- Plaque psoriasis
Adverse Drug Interactions
- Cautions:
- Antidiabetics: Increased risk of hypoglycemia
- Cyclophosphamide: Higher risk of solid malignancies
- Vaccines: May be less effective due to immune suppression
- Sulfasalazine: Risk of decreased neutrophil count
Routes of Administration
- Administration Method: Subcutaneous (subQ) injection is the primary route.
Patient Teaching
- Key Instructions:
- Rotate injection sites to prevent irritation.
- Injection site reactions typically resolve within 3-5 days.
- Advise reporting any signs of fever or infection promptly.
- Female patients should discontinue breastfeeding before starting therapy.
Nursing Implications
- Monitoring Needs:
- Vigilantly monitor for signs of infections during treatment.
- Regularly assess for potential malignancies.
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