18 Questions
Which route of administration is typically required for anti-TNF biologics?
Intravenous
Which enzyme in the liver is responsible for metabolizing many biologics including anti-TNF agents?
Cytochromes P450
Which of the following diseases is NOT mentioned as being impacted by TNF-α?
Multiple Sclerosis
What is the mechanism of action of Infliximab in neutralizing TNF-α?
Binding to membrane-bound TNF trimer
Which anti-TNF biologic has a portion of its structure derived from a mouse?
Golimumab
What is the frequency of dosing for anti-TNF biologics compared to small molecule drugs?
Less frequent
What adverse effect is associated with TNFα inhibitors?
Reactivation of latent tuberculosis
Which statement about anti-B lymphocyte biologics is true?
Rituximab blocks B cell activation
Which biologic is derived from various types of immune cells and elevated in many inflammatory diseases?
IL-12/23 biologics
What is a common feature of anti-integrin biologics?
They inhibit leukocyte extravasation
What is a distinguishing characteristic of anti-cytokine biologics such as Ustekinumab?
They block the p40 subunit of IL-12/23
What is a key advantage of monoclonal antibodies?
Most side effects are intrinsic to the action of the drug at its target
Which is a false statement regarding anti-TNF biologics?
These drugs have limited efficacy in treating chronic inflammatory diseases
Which type of proteins are big targets for monoclonal antibodies in immune-mediated diseases and oncology?
Cell surface proteins
What is a significant disadvantage of monoclonal antibodies?
Parenteral administration
How are monoclonal antibodies eliminated from the body?
Receptor-mediated endocytosis and intracellular catabolism by lysosomal degradation
Why can monoclonal antibodies induce anti-drug immune responses?
Because they are recognized as self-proteins by the immune system
What is the significance of immunogenicity in relation to monoclonal antibodies?
Immunogenicity can lead to faster drug clearance and reduced efficacy
Learn about the effects of TNF inhibitors on TNF-producing cells, apoptosis, immunogenicity, and the effectiveness of Etanercept in rheumatoid arthritis and inflammatory bowel disease. Discover the adverse effects associated with TNF inhibitors like reactivation of latent tuberculosis and increased risk of opportunistic infections.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
