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18 Questions

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Effects of TNF Inhibitors in RA and IBD

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Questions and Answers

Which route of administration is typically required for anti-TNF biologics?

Topical

Intravenous (correct)

Subcutaneous

Oral

Which enzyme in the liver is responsible for metabolizing many biologics including anti-TNF agents?

Cytochrome P450 reductase

Cytochromes P450 (correct)

Cytochrome C oxidase

Cytochrome b5 reductase

Which of the following diseases is NOT mentioned as being impacted by TNF-α?

Rheumatoid Arthritis (RA)

Multiple Sclerosis (correct)

Inflammatory Bowel Disease (IBD)

Psoriasis

What is the mechanism of action of Infliximab in neutralizing TNF-α?

Binding to membrane-bound TNF trimer Signup and view all the answers

Which anti-TNF biologic has a portion of its structure derived from a mouse?

Golimumab Signup and view all the answers

What is the frequency of dosing for anti-TNF biologics compared to small molecule drugs?

Less frequent Signup and view all the answers

What adverse effect is associated with TNFα inhibitors?

Reactivation of latent tuberculosis Signup and view all the answers

Which statement about anti-B lymphocyte biologics is true?

Rituximab blocks B cell activation Signup and view all the answers

Which biologic is derived from various types of immune cells and elevated in many inflammatory diseases?

IL-12/23 biologics Signup and view all the answers

What is a common feature of anti-integrin biologics?

They inhibit leukocyte extravasation Signup and view all the answers

What is a distinguishing characteristic of anti-cytokine biologics such as Ustekinumab?

They block the p40 subunit of IL-12/23 Signup and view all the answers

What is a key advantage of monoclonal antibodies?

Most side effects are intrinsic to the action of the drug at its target Signup and view all the answers

Which is a false statement regarding anti-TNF biologics?

These drugs have limited efficacy in treating chronic inflammatory diseases Signup and view all the answers

Which type of proteins are big targets for monoclonal antibodies in immune-mediated diseases and oncology?

Cell surface proteins Signup and view all the answers

What is a significant disadvantage of monoclonal antibodies?

Parenteral administration Signup and view all the answers

How are monoclonal antibodies eliminated from the body?

Receptor-mediated endocytosis and intracellular catabolism by lysosomal degradation Signup and view all the answers

Why can monoclonal antibodies induce anti-drug immune responses?

Because they are recognized as self-proteins by the immune system Signup and view all the answers

What is the significance of immunogenicity in relation to monoclonal antibodies?

Immunogenicity can lead to faster drug clearance and reduced efficacy Signup and view all the answers