Podcast
Questions and Answers
Which route of administration is typically required for anti-TNF biologics?
Which route of administration is typically required for anti-TNF biologics?
- Topical
- Intravenous (correct)
- Subcutaneous
- Oral
Which enzyme in the liver is responsible for metabolizing many biologics including anti-TNF agents?
Which enzyme in the liver is responsible for metabolizing many biologics including anti-TNF agents?
- Cytochrome P450 reductase
- Cytochromes P450 (correct)
- Cytochrome C oxidase
- Cytochrome b5 reductase
Which of the following diseases is NOT mentioned as being impacted by TNF-α?
Which of the following diseases is NOT mentioned as being impacted by TNF-α?
- Rheumatoid Arthritis (RA)
- Multiple Sclerosis (correct)
- Inflammatory Bowel Disease (IBD)
- Psoriasis
What is the mechanism of action of Infliximab in neutralizing TNF-α?
What is the mechanism of action of Infliximab in neutralizing TNF-α?
Which anti-TNF biologic has a portion of its structure derived from a mouse?
Which anti-TNF biologic has a portion of its structure derived from a mouse?
What is the frequency of dosing for anti-TNF biologics compared to small molecule drugs?
What is the frequency of dosing for anti-TNF biologics compared to small molecule drugs?
What adverse effect is associated with TNFα inhibitors?
What adverse effect is associated with TNFα inhibitors?
Which statement about anti-B lymphocyte biologics is true?
Which statement about anti-B lymphocyte biologics is true?
Which biologic is derived from various types of immune cells and elevated in many inflammatory diseases?
Which biologic is derived from various types of immune cells and elevated in many inflammatory diseases?
What is a common feature of anti-integrin biologics?
What is a common feature of anti-integrin biologics?
What is a distinguishing characteristic of anti-cytokine biologics such as Ustekinumab?
What is a distinguishing characteristic of anti-cytokine biologics such as Ustekinumab?
What is a key advantage of monoclonal antibodies?
What is a key advantage of monoclonal antibodies?
Which is a false statement regarding anti-TNF biologics?
Which is a false statement regarding anti-TNF biologics?
Which type of proteins are big targets for monoclonal antibodies in immune-mediated diseases and oncology?
Which type of proteins are big targets for monoclonal antibodies in immune-mediated diseases and oncology?
What is a significant disadvantage of monoclonal antibodies?
What is a significant disadvantage of monoclonal antibodies?
How are monoclonal antibodies eliminated from the body?
How are monoclonal antibodies eliminated from the body?
Why can monoclonal antibodies induce anti-drug immune responses?
Why can monoclonal antibodies induce anti-drug immune responses?
What is the significance of immunogenicity in relation to monoclonal antibodies?
What is the significance of immunogenicity in relation to monoclonal antibodies?
