Podcast
Questions and Answers
What is the generic name and class of Enbrel?
What is the generic name and class of Enbrel?
Etanercept, TNF blocker
How effective is Enbrel?
How effective is Enbrel?
Enbrel is effective at treating multiple indications.
When did the clinical trials for Enbrel begin?
When did the clinical trials for Enbrel begin?
1993
Which of the following are indications for Enbrel? (Select all that apply)
Which of the following are indications for Enbrel? (Select all that apply)
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Patients treated with Enbrel are at increased risk for developing serious infections.
Patients treated with Enbrel are at increased risk for developing serious infections.
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What are some common side effects of Enbrel?
What are some common side effects of Enbrel?
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What is the recommended starting dose of Enbrel for adult patients?
What is the recommended starting dose of Enbrel for adult patients?
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How can Enbrel be administered?
How can Enbrel be administered?
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What is the mechanism of action of Enbrel?
What is the mechanism of action of Enbrel?
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Enbrel has established a safety profile in rheumatology.
Enbrel has established a safety profile in rheumatology.
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What type of malignancies were reported in pediatric patients taking Enbrel?
What type of malignancies were reported in pediatric patients taking Enbrel?
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Caution should be used when administering Enbrel to patients with congestive heart failure (CHF).
Caution should be used when administering Enbrel to patients with congestive heart failure (CHF).
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Which of the following drug interactions are relevant to Enbrel? (Select all that apply)
Which of the following drug interactions are relevant to Enbrel? (Select all that apply)
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What savings program does Enbrel offer for patients?
What savings program does Enbrel offer for patients?
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What does the Safety Net Foundation provide for uninsured patients?
What does the Safety Net Foundation provide for uninsured patients?
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Study Notes
Enbrel Overview
- Enbrel's generic name is etanercept; it belongs to the TNF blocker drug class.
- Effective for treating various medical conditions.
Clinical Trials
- Phase 1 study for rheumatoid arthritis (RA) began in 1993, marking the start of extensive clinical research.
- Over 100 global trials conducted for multiple indications.
Indications
- Treats rheumatoid arthritis, polyarticular juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis.
- Applicable to both adult and pediatric patients.
Safety Concerns
- Increased risk of serious infections, potentially leading to hospitalization or death.
Side Effects
- Common side effects include headache, stomach pain, nausea, vomiting, heartburn, weakness, cough, and injection site reactions (redness, itching, pain, swelling).
Dosing Guidelines
- Adult dosing starts with 50 mg twice weekly for 3 months, followed by a maintenance dose of 50 mg weekly thereafter.
- Dosing varies based on specific indications.
Administration Methods
- Can be administered via syringe or the SureClick autoinjector.
Mechanism of Action
- Enbrel acts as a soluble TNF receptor and is constructed as a dimeric fusion protein combining TNFR and the Fc portion of human IgG1.
Safety Profile
- Established safety profile in rheumatology settings, indicating a beneficial risk-to-benefit ratio for patients.
Pediatric Considerations
- Approximately half of reported malignancies in patients starting therapy at 18 years or younger were lymphomas, affecting both Hodgkin's and non-Hodgkin's types.
Congestive Heart Failure (CHF)
- Worsening CHF or new-onset cases reported; caution advised for CHF patients, requiring careful monitoring.
Drug Interactions
- Concurrent use with cyclophosphamide not recommended due to increased infection risk.
- Avoid combination therapy with abatacept and anakinra.
Cost and Patient Assistance
- Offers a savings card to enable patients to obtain Enbrel for $0.
- The Safety Net Foundation provides Enbrel for free to uninsured or underinsured patients who qualify.
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Description
Test your knowledge about Enbrel, its generic name etanercept, and its classification as a TNF blocker. This quiz also covers its efficacy in treating conditions like rheumatoid arthritis and details surrounding clinical trials. Perfect for students and professionals in the medical field.
