Erythropoiesis Process Quiz

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which type of factors act on cells and induce multiplication and simple cell division producing a clone typical to the original cell?

  • Cytokines
  • Proliferation factors (correct)
  • Hormones
  • Differentiation factors

What type of cells are responsible for giving rise to chondrocytes, adipocytes, and osteoblasts?

  • Pluripotent Stem Cells (PSC)
  • Mesenchymal Stem Cells (correct)
  • Pluripotent Hematopoietic Stem Cells (PHSC)
  • Erythro poiesis cells

Where does erythro poiesis, the formation of red blood cells, primarily take place?

  • Liver
  • Kidneys
  • Spleen
  • Bone marrow (correct)

Which group of cells has the ability to give rise to different cell types like hepatocytes or neurons?

<p>Mesenchymal Stem Cells (C)</p> Signup and view all the answers

What is the environment in the bone marrow characterized by due to the availability of proliferation and differentiation factors?

<p>Conserved environment (C)</p> Signup and view all the answers

Which type of stem cells are responsible for giving rise to blood cells?

<p>Pluripotent Stem Cells (PSC) (B)</p> Signup and view all the answers

What happens if the bone marrow fails to function during adulthood?

<p>Liver and spleen start making RBCs (D)</p> Signup and view all the answers

What is the role of differentiation factors and cell signaling pathways in pluripotent hematopoietic stem cells (PHSC)?

<p>Induce production of different types of blood cells (A)</p> Signup and view all the answers

How many amino acids are present in the beta chain of hemoglobin?

<p>146 AAs (A)</p> Signup and view all the answers

What attributes do common myeloid progenitor (CMP) cells gain during hematopoiesis?

<p>Responsibility for producing red blood cells and platelets (A)</p> Signup and view all the answers

What molecule allows iron to bind oxygen in the heme group of hemoglobin?

<p>Protoporphyrin ring (A)</p> Signup and view all the answers

What is the role of mitochondria in hematopoietic stem cells (HSC)?

<p>Energy production through the Electron transport chain (D)</p> Signup and view all the answers

What is the consequence of iron in the heme group oxidizing to Fe3+?

<p>Formation of methemoglobin (D)</p> Signup and view all the answers

Which type of progenitor cell gives rise to granulocytes like neutrophils and eosinophils?

<p>Granulocyte-monocyte progenitor (GMP) (A)</p> Signup and view all the answers

How many oxygen molecules can each hemoglobin molecule transport?

<p>Four oxygen molecules (B)</p> Signup and view all the answers

What is the sequential pathway from hematopoietic stem cell (HSC) to mature red blood cell (Erythrocyte)?

<p>$HSC \rightarrow MEP \rightarrow Mature RBC$ (D)</p> Signup and view all the answers

What is the function of the globin in the hemoglobin molecule?

<p>Provides protein structure (D)</p> Signup and view all the answers

Which organelle is involved in protein synthesis in hematopoietic stem cells?

<p>Endoplasmic Reticulum and Ribosomes (C)</p> Signup and view all the answers

Which organelle is found in a reticulocyte?

<p>Mitochondria (C)</p> Signup and view all the answers

What process do reticulocytes go through over the course of 2 days?

<p>Proteasomal degradation (B)</p> Signup and view all the answers

What gives mature erythrocytes their red color?

<p>Hemoglobin (A)</p> Signup and view all the answers

Why do mature erythrocytes have a biconcave shape?

<p>They have a high surface area to volume ratio (D)</p> Signup and view all the answers

Which of the following is NOT a substrate required for erythropoiesis?

<p>Hemoglobin (C)</p> Signup and view all the answers

How do reticulocytes leave the bone marrow and enter circulation?

<p>Via diapedesis similar to neutrophils (A)</p> Signup and view all the answers

Which transcription factor is involved in initiating erythroid differentiation from pluripotential stem cells?

<p>GATA 1 (B)</p> Signup and view all the answers

How do erythropoietin receptor stimulation affects the expression of erythroid-specific genes?

<p>Enhancing expression of globin, heme biosynthetic genes, and red cell membrane proteins (D)</p> Signup and view all the answers

Which factor stimulates both erythropoietin production and new vessel formation?

<p>HIF-1β (A)</p> Signup and view all the answers

Which type of receptor is the EpoR that stimulates erythropoiesis?

<p>Type I cytokine receptor (C)</p> Signup and view all the answers

What is the main pathway activated by EpoR to stimulate erythropoiesis?

<p>Jak/STAT signaling cascade (B)</p> Signup and view all the answers

Which tyrosine kinase is associated with the membrane-proximal regions of EpoR intracellular domains?

<p>JAK 2 (D)</p> Signup and view all the answers

What happens to the nucleus in an erythroblast during the process of enucleation?

<p>It is phagocytosed by a macrophage. (B)</p> Signup and view all the answers

What organelles are found in a reticulocyte before it matures into an erythrocyte?

<p>Few mitochondria and many ribosomes. (B)</p> Signup and view all the answers

During erythropoiesis, what structures does a reticulocyte lose while circulating in the blood?

<p>Endoplasmic reticulum remnants and ribosomes. (A)</p> Signup and view all the answers

What is the main component of mature erythrocytes that allows them to carry oxygen?

<p>Hemoglobin (D)</p> Signup and view all the answers

Why do mature erythrocytes have a biconcave shape?

<p>To increase surface area for gas exchange. (A)</p> Signup and view all the answers

What substrates are required for hemoglobin synthesis during erythropoiesis?

<p>Iron and vitamin C (D)</p> Signup and view all the answers

What process leads to the maturation of a reticulocyte into a mature erythrocyte?

<p>Proteasomal degradation (B)</p> Signup and view all the answers

What is the primary function of the reticulocyte before it matures into an erythrocyte?

<p>Protein synthesis (A)</p> Signup and view all the answers

Which cellular process occurs during the transition from a reticulocyte to a mature erythrocyte?

<p>Endocytosis of cytoplasmic organelles (B)</p> Signup and view all the answers

What structural feature differentiates a mature erythrocyte from other blood cells?

<p>High surface area to volume ratio (D)</p> Signup and view all the answers

Flashcards are hidden until you start studying

Related Documents

More Like This

Use Quizgecko on...
Browser
Browser