Podcast
Questions and Answers
What was Ernest McCulloch's primary area of medical specialization?
What was Ernest McCulloch's primary area of medical specialization?
- Biophysics
- Pathology
- Hematology (correct)
- Oncology
Where did Ernest McCulloch conduct his pivotal stem cell research?
Where did Ernest McCulloch conduct his pivotal stem cell research?
- Lister Institute, London
- Ontario Cancer Institute (correct)
- University of Toronto
- Sunnybrook Hospital, Toronto
What was James Till's academic background before transitioning to cancer research?
What was James Till's academic background before transitioning to cancer research?
- Biochemistry
- Hematology
- Medicine
- Physics (correct)
In what year did McCulloch and Till publish their findings on the "radiation sensitivity of mouse bone marrow cells"?
In what year did McCulloch and Till publish their findings on the "radiation sensitivity of mouse bone marrow cells"?
Besides stem cell research, what other area of medical research did James Till contribute to later in his career?
Besides stem cell research, what other area of medical research did James Till contribute to later in his career?
What prestigious award did McCulloch and Till jointly receive for their contributions to basic medical research?
What prestigious award did McCulloch and Till jointly receive for their contributions to basic medical research?
In what year did McCulloch become the Departmental Head of Hematology at the Ontario Cancer Institute?
In what year did McCulloch become the Departmental Head of Hematology at the Ontario Cancer Institute?
Where did James Till complete his PhD in Biophysics?
Where did James Till complete his PhD in Biophysics?
Which journal published McCulloch, Till, and Becker's significant stem cell research findings in 1963?
Which journal published McCulloch, Till, and Becker's significant stem cell research findings in 1963?
In which year were McCulloch and Till inducted into the Canadian Science and Engineering Hall of Fame?
In which year were McCulloch and Till inducted into the Canadian Science and Engineering Hall of Fame?
Flashcards
Ernest McCulloch
Ernest McCulloch
A Canadian hematologist who pioneered stem cell research and cancer treatments.
James Till
James Till
A physicist who collaborated on pioneering stem cell discoveries with McCulloch.
Stem Cell Research
Stem Cell Research
Study focused on stem cells which can develop into any blood cell and have potential in medical therapies.
Ontario Cancer Institute
Ontario Cancer Institute
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Radiation Sensitivity
Radiation Sensitivity
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Albert Lasker Award
Albert Lasker Award
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Canadian Science and Engineering Hall of Fame
Canadian Science and Engineering Hall of Fame
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Blood Stem Cells
Blood Stem Cells
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Research Ethics
Research Ethics
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Patient Quality of Life
Patient Quality of Life
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Study Notes
Ernest McCulloch and James Till
- McCulloch, a hematologist, sought a leukemia cure. A radiation experiment led to his discovery of something new.
- Born and raised in Toronto, McCulloch studied medicine at the University of Toronto, becoming a doctor in 1948.
- He worked as a research fellow in pathology at the Lister Institute in London, UK, and later at Sunnybrook Hospital.
- In 1957, McCulloch joined the Ontario Cancer Institute.
- His work focused on blood cell formation, encompassing both normal and malignant cells, in collaboration with James Till.
- Their research on stem cells revolutionized cancer research and led to regenerative medicine.
- McCulloch was a key figure in Canadian medical research, serving on national and international advisory committees.
James Till
- Till, a physicist, turned his attention to cancer research while working on radiation treatments.
- Growing up in a rural community in Lloydminster, Canada, Till won a scholarship to the University of Saskatchewan.
- He earned a PhD in biophysics from Yale University in 1957 and took on a research fellowship at the University of Toronto.
- In 1958, he joined the Ontario Cancer Institute where he conducted research with McCulloch.
- They made groundbreaking discoveries regarding stem cells, analyzing the mechanisms of human leukemia in the 1970s.
- Till's work included research ethics, patient quality of life, and the role of the internet in patient advocacy.
Discovery of Stem Cells
- McCulloch and Till discovered that most bones contain unspecialized cells, called adult stem cells, in the inner marrow.
- These cells have the potential to develop into any blood cell type.
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