Podcast
Questions and Answers
What was Ernest McCulloch's area of medical specialization?
What was Ernest McCulloch's area of medical specialization?
- Oncology
- Neurology
- Hematology (correct)
- Cardiology
Where did Ernest McCulloch conduct his stem cell research?
Where did Ernest McCulloch conduct his stem cell research?
- Ontario Cancer Institute (correct)
- Lister Institute, London
- University of Toronto
- Sunnybrook Hospital, Toronto
What was James Till's academic background before turning to cancer research?
What was James Till's academic background before turning to cancer research?
- Physics (correct)
- Biochemistry
- Medical Doctor (MD)
- Biology
In what year did McCulloch and Till publish their findings on the "radiation sensitivity of mouse bone marrow cells"?
In what year did McCulloch and Till publish their findings on the "radiation sensitivity of mouse bone marrow cells"?
Which prestigious award did McCulloch and Till jointly receive for their contributions to basic medical research?
Which prestigious award did McCulloch and Till jointly receive for their contributions to basic medical research?
In which year were McCulloch and Till inducted into the Canadian Science and Engineering Hall of Fame?
In which year were McCulloch and Till inducted into the Canadian Science and Engineering Hall of Fame?
What was one of the key areas of focus in James Till's later research career?
What was one of the key areas of focus in James Till's later research career?
What did McCulloch and Till's research uncover about the location and potential of adult stem cells?
What did McCulloch and Till's research uncover about the location and potential of adult stem cells?
When did McCulloch become the Departmental Head of Hematology at the Ontario Cancer Institute?
When did McCulloch become the Departmental Head of Hematology at the Ontario Cancer Institute?
What was the initial aim of McCulloch's Leukemia research?
What was the initial aim of McCulloch's Leukemia research?
Flashcards
Ernest McCulloch
Ernest McCulloch
A Canadian hematologist who advanced stem cell research and cancer treatment.
James Till
James Till
A physicist turned cancer researcher, known for stem cell collaboration with McCulloch.
Ontario Cancer Institute
Ontario Cancer Institute
Research facility where McCulloch and Till worked and collaborated on stem cells.
Stem cells
Stem cells
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Albert Lasker Award
Albert Lasker Award
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Radiation sensitivity
Radiation sensitivity
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Canadian Science and Engineering Hall of Fame
Canadian Science and Engineering Hall of Fame
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Patient quality of life
Patient quality of life
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Cure for leukemia
Cure for leukemia
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Transformative work
Transformative work
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Study Notes
Ernest McCulloch and James Till
- McCulloch, a hematologist, sought a leukemia cure. A radiation experiment led to a new understanding of cells.
- McCulloch was born and raised in Toronto, studied medicine at the University of Toronto, and became a doctor in 1948.
- He worked at the Lister Institute in London, and then a research fellow in pathology at Sunnybrook Hospital.
- In 1957, he joined Ontario Cancer Institute.
- Their work on stem cells revolutionized cancer research and regenerative medicine.
- McCulloch was a key figure in Canadian medical research and served on numerous national and international advisory bodies.
- He was the "big picture" thinker in biomedical research.
James Till
- Till, a physicist, shifted his focus to cancer research while working with radiation treatments.
- He discovered stem cells with McCulloch.
- Born in Lloydminster, Canada, and won a scholarship to the University of Saskatchewan to study physics.
- Earned a PhD in Biophysics from Yale University in 1957.
- Became a research fellow at the University of Toronto
- Joined the Ontario Cancer Institute in 1958, where he worked with McCulloch and further pursued cancer research.
- His research delved into cancer treatment, patient quality of life, and ethical considerations in research.
- His research emphasized the effects of radiation on mouse bone marrow cells.
Stem Cell Discovery
- McCulloch and Till's research uncovered adult stem cells within the bone marrow.
- These unspecialized cells have the potential to develop into various blood cells.
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