21 Questions
What is the significant side effect of eplerenone?
Hyperkalemia
How does eplerenone affect the excretion of potassium in the kidney?
Retains potassium
What effect does eplerenone have on sodium and water excretion?
Increases excretion of sodium and water
Which drugs should eplerenone not be combined with due to the risk of hyperkalemia?
Potassium sparing drugs
What is the impact of inhibitors of CYP3A4 on eplerenone levels?
They can double eplerenone levels
What is the therapeutic use of eplerenone?
Treatment of hypertension and heart failure
What distinguishes finerenone from spironolactone and eplerenone?
It is a non-steroidal MRA unlike spironolactone and eplerenone
What can occur if eplerenone is combined with a strong CYP3A4 inhibitor?
Increase in eplerenone levels by fivefold
What is the impact of eplerenone on aldosterone receptors for other steroid hormones?
Selective blockade of aldosterone receptors for other steroid hormones
Which adverse effect can occur due to potassium retention from eplerenone?
Muscle weakness and cramps
What is the primary mechanism of action of eplerenone?
Selective blockade of aldosterone receptors
What is the significant side effect associated with eplerenone use?
Hyperkalemia
How does eplerenone affect potassium and sodium excretion in the kidney?
Promotes potassium retention and sodium excretion
What is the potential risk when eplerenone is combined with a strong CYP3A4 inhibitor?
Increased eplerenone levels
Which adverse effect can occur as a result of potassium retention from eplerenone?
Gynecomastia
How do eplerenone and spironolactone differ in their classification as MRAs?
Eplerenone is a non-steroidal MRA, but spironolactone is a steroidal MRA
What is the therapeutic use of eplerenone?
Management of hypertension and heart failure
Which of the following drugs should not be combined with eplerenone due to the risk of hyperkalemia?
Angiotensin-converting enzyme (ACE) inhibitors
What impact do weak inhibitors of CYP3A4 have on eplerenone levels?
They can double eplerenone levels
What adverse effect is associated with eplerenone use and can occur as a result of diarrhea?
Hyperkalemia
What is the impact of inhibiting CYP3A4 on eplerenone levels when combined with a strong inhibitor?
Eplerenone levels increase fivefold
Test your knowledge about the pharmacology and clinical applications of eplerenone, a selective aldosterone receptor blocker used for hypertension and heart failure. Learn about its side effects, mechanism of action, and therapeutic uses.
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