Eplerenone: Pharmacology and Clinical Applications
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Questions and Answers

What is the significant side effect of eplerenone?

  • Hyperkalemia (correct)
  • Heart failure
  • Hypertension
  • Gynecomastia

    • How does eplerenone affect the excretion of potassium in the kidney?

  • Promotes excretion of potassium
  • Increases sodium and water excretion
  • Retains potassium (correct)
  • Has no effect on potassium excretion

    • What effect does eplerenone have on sodium and water excretion?

  • Has no effect on sodium and water excretion
  • Increases excretion of sodium and water (correct)
  • Promotes excretion of sodium and retention of water
  • Promotes retention of sodium and water

    • Which drugs should eplerenone not be combined with due to the risk of hyperkalemia?

    <p>Potassium sparing drugs</p> Signup and view all the answers

    What is the impact of inhibitors of CYP3A4 on eplerenone levels?

    <p>They can double eplerenone levels</p> Signup and view all the answers

    What is the therapeutic use of eplerenone?

    <p>Treatment of hypertension and heart failure</p> Signup and view all the answers

    What distinguishes finerenone from spironolactone and eplerenone?

    <p>It is a non-steroidal MRA unlike spironolactone and eplerenone</p> Signup and view all the answers

    What can occur if eplerenone is combined with a strong CYP3A4 inhibitor?

    <p>Increase in eplerenone levels by fivefold</p> Signup and view all the answers

    What is the impact of eplerenone on aldosterone receptors for other steroid hormones?

    <p>Selective blockade of aldosterone receptors for other steroid hormones</p> Signup and view all the answers

    Which adverse effect can occur due to potassium retention from eplerenone?

    <p>Muscle weakness and cramps</p> Signup and view all the answers

    What is the primary mechanism of action of eplerenone?

    <p>Selective blockade of aldosterone receptors</p> Signup and view all the answers

    What is the significant side effect associated with eplerenone use?

    <p>Hyperkalemia</p> Signup and view all the answers

    How does eplerenone affect potassium and sodium excretion in the kidney?

    <p>Promotes potassium retention and sodium excretion</p> Signup and view all the answers

    What is the potential risk when eplerenone is combined with a strong CYP3A4 inhibitor?

    <p>Increased eplerenone levels</p> Signup and view all the answers

    Which adverse effect can occur as a result of potassium retention from eplerenone?

    <p>Gynecomastia</p> Signup and view all the answers

    How do eplerenone and spironolactone differ in their classification as MRAs?

    <p>Eplerenone is a non-steroidal MRA, but spironolactone is a steroidal MRA</p> Signup and view all the answers

    What is the therapeutic use of eplerenone?

    <p>Management of hypertension and heart failure</p> Signup and view all the answers

    Which of the following drugs should not be combined with eplerenone due to the risk of hyperkalemia?

    <p>Angiotensin-converting enzyme (ACE) inhibitors</p> Signup and view all the answers

    What impact do weak inhibitors of CYP3A4 have on eplerenone levels?

    <p>They can double eplerenone levels</p> Signup and view all the answers

    What adverse effect is associated with eplerenone use and can occur as a result of diarrhea?

    <p>Hyperkalemia</p> Signup and view all the answers

    What is the impact of inhibiting CYP3A4 on eplerenone levels when combined with a strong inhibitor?

    <p>Eplerenone levels increase fivefold</p> Signup and view all the answers

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