Podcast
Questions and Answers
What is the effect of benzodiazepines on the GABAA receptor in the absence of GABA?
What is the effect of benzodiazepines on the GABAA receptor in the absence of GABA?
- Increases the affinity of GABA for its binding site
- Has no effect (correct)
- Inhibits the action of GABA
- Enhances the membrane currents induced by GABA
What is the minimum number of subunits required to form a functional GABAA receptor?
What is the minimum number of subunits required to form a functional GABAA receptor?
- 4
- 6
- 5 (correct)
- 3
What is the binding site for benzodiazepines on the GABAA receptor?
What is the binding site for benzodiazepines on the GABAA receptor?
- Transmembrane domain of g subunits
- Intracellular domain of b subunits
- C-terminal domain of d subunits
- Extracellular domain of a subunits (correct)
What is the effect of activating the a1 subunit BZD site on the GABAA receptor?
What is the effect of activating the a1 subunit BZD site on the GABAA receptor?
What is the number of known a subunits in the GABAA receptor?
What is the number of known a subunits in the GABAA receptor?
What is the effect of GABA on the GABAA receptor in the presence of benzodiazepines?
What is the effect of GABA on the GABAA receptor in the presence of benzodiazepines?
What is observed when use-dependent Na channel blockers are applied to mouse spinal cord neurons in culture?
What is observed when use-dependent Na channel blockers are applied to mouse spinal cord neurons in culture?
What is the characteristic of monogenic epilepsy?
What is the characteristic of monogenic epilepsy?
What is the consequence of GABA-T (GABA transaminase) and SSADH mutations?
What is the consequence of GABA-T (GABA transaminase) and SSADH mutations?
What is the main application of the kindling phenomenon in the field of neuroscience?
What is the main application of the kindling phenomenon in the field of neuroscience?
What is the effect of a use-dependent Na or Ca channel blocker on firing rate control?
What is the effect of a use-dependent Na or Ca channel blocker on firing rate control?
What is the primary mechanism of action of barbiturates and benzodiazepines in suppressing neuronal excitability?
What is the primary mechanism of action of barbiturates and benzodiazepines in suppressing neuronal excitability?
What is the primary function of the GABAB receptor in the brain?
What is the primary function of the GABAB receptor in the brain?
What is the characteristic of idiopathic epilepsies?
What is the characteristic of idiopathic epilepsies?
What is the name of the syndrome associated with monogenic epilepsy?
What is the name of the syndrome associated with monogenic epilepsy?
What is the percentage of synapses in the brain that involve the neurotransmitter GABA?
What is the percentage of synapses in the brain that involve the neurotransmitter GABA?
Which of the following anti-epileptic drugs acts by blocking voltage-dependent Na or Ca channels?
Which of the following anti-epileptic drugs acts by blocking voltage-dependent Na or Ca channels?
What is the name of the agonist that acts on the GABAB receptor?
What is the name of the agonist that acts on the GABAB receptor?
What is the mechanism of action of vigabatrin on GABA?
What is the mechanism of action of vigabatrin on GABA?
What is the primary mechanism of action of benzodiazepines in treating seizures?
What is the primary mechanism of action of benzodiazepines in treating seizures?
Which type of seizures is ethosuximide specifically used to treat?
Which type of seizures is ethosuximide specifically used to treat?
What is the mechanism of action of carbamazepine and phenytoin?
What is the mechanism of action of carbamazepine and phenytoin?
What is the effect of tiagabine on GABA concentration?
What is the effect of tiagabine on GABA concentration?
What is the characteristic of the binding of carbamazepine and phenytoin to voltage-gated sodium channels?
What is the characteristic of the binding of carbamazepine and phenytoin to voltage-gated sodium channels?
Which of the following anticonvulsant drugs acts by enhancing the opening of K+ channels of the KCNQ type?
Which of the following anticonvulsant drugs acts by enhancing the opening of K+ channels of the KCNQ type?
What is the mechanism of action of sodium valproate in terms of voltage-gated sodium channels?
What is the mechanism of action of sodium valproate in terms of voltage-gated sodium channels?
Which anticonvulsant drug is associated with fetal abnormalities?
Which anticonvulsant drug is associated with fetal abnormalities?
Which of the following anticonvulsant drugs is thought to act as an antagonist of AMPA receptors?
Which of the following anticonvulsant drugs is thought to act as an antagonist of AMPA receptors?
Which anticonvulsant drug binds to a synaptic vesicle protein called SV2A?
Which anticonvulsant drug binds to a synaptic vesicle protein called SV2A?
What is the molecular target of gabapentin and pregabalin?
What is the molecular target of gabapentin and pregabalin?
