16 Questions
What can result in epigenetic effects?
Both a and b
How is hemimethylated DNA produced?
By the replication of methylated DNA
What is the role of proteins in nucleation of heterochromatin?
They bind to specific sequences and cause heterochromatin nucleation
What is the consequence of inactivation of genes within regions of heterochromatin?
Position effect variegation (PEV)
What is a prion?
A proteinaceous infectious agent that behaves as an inheritable trait, although it contains no nucleic acid
What creates heterochromatin?
Proteins associating with histones
Which protein is the key in forming mammalian heterochromatin?
HP1
What is the function of Rap1 in yeast in relation to heterochromatin formation?
Binds to specific target sequences in DNA to initiate heterochromatin formation
What is the role of Polycomb group proteins (Pc-G) in gene regulation?
Maintain repression through cell divisions
What does a Polycomb response element (PRE) provide in gene regulation?
A nucleation center for heterochromatin formation
Where are most methyl groups in DNA found?
On cytosine (C) in CpG doublets
What happens to a fully methylated DNA site during replication?
Converts to a hemimethylated site
What is the function of DNA methyltransferase?
Adds a methyl group to a specific target sequence in DNA
What is the role of RNAi pathways in relation to heterochromatin formation?
Promote heterochromatin formation at centromeres
What promotes the spreading of Sir3 and Sir4 in yeast?
Sir2
Which protein initiates the formation of heterochromatin in yeast by binding to specific target sequences in DNA?
Rap1
Test your knowledge of Chapter 27 'Epigenetics I' with a focus on the introduction and mechanisms of epigenetic effects, including the modification of nucleic acids and perpetuation of protein structures. This quiz covers topics such as hemimethylated DNA, heterochromatin, and prion behavior.
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